Flexon Tablet

Generic Name(s): Ibuprofen, Paracetamol

Why it's used

Flexon Tablet is used for temporary relief of pain associated with a headache, backache, migraine, period pain, muscular pain, dental pain, sore throat, cold and flu symptoms, and fever. This medicine works by blocking the activity of a chemical in the brain that causes pain. Flexon is also used to reduce fever. It is also used to reduce inflammation (redness, swelling, and soreness).
Nonsteroidal Anti-inflammatory Drugs
Flexon belongs to a class of medicines called Nonsteroidal Anti-inflammatory Drugs. Nonsteroidal anti-inflammatory drugs, also called as NSAIDs, help reduce fever, decrease pain, and prevent clotting of blood. NSAIDs also reduce inflammation in the body when used in higher doses.

How to use

Read the medicine guide provided by your pharmacist, your doctor, or the medicine company. If you have any questions related to Flexon, ask your doctor or pharmacist. UseFlexon Tabletas per the instructions provided by your doctor.
Flexon is eaten with or after food. This medicine should be taken with a full glass of water.
The typical dose of Flexon for adults is 500 mg - 1000 mg of Paracetamol with 150 mg - 300 mg of Ibuprofen every 6 hours (not more than 3000 mg of Paracetamol with 900 mg of Ibuprofen in one day). The maximum dose for adult patients of Flexon is 3000 mg of Paracetamol with 900 mg of Ibuprofen per day.
This medicine should be used on an as-needed basis.
Discuss with your doctor if your condition persists or worsens or if you develop new symptoms.
Taking a higher dose of this medicine may increase the risk of side-effects. A lower dose of this medicine may be recommended to reduce the risk of side-effects. Older patients may see an increase in the incidence of side-effects. As a result, a lower dose may be recommended for older patients.
When stopping this medicine, some patients may experience withdrawal symptoms like excess fluids build up inside the body (fluid retention).
The safety and effectiveness of usingFlexon Tabletin children has not been established. Flexon is not recommended for children under 18 years.
Avoid consuming alcohol together with Flexon.
Medicines may be recommended for uses other than those listed in the medicine guide. You should not use Flexon Tablet for conditions or symptoms for which it was not prescribed. Do not giveFlexon Tabletto other people, even if they have the same conditions or symptoms that you have. The use of this medicine without the advice of a doctor may cause harm.
Follow storage instructions on the product package if available. Store Flexon Tablet at below 30°C (86 °F), and away from light. Store this medicine away from children and pets.

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How to take Flexon

The dose and frequency of using Flexon will depend on the following factors:
  • age of the patient
  • patient's health

Flexon Dosage

Dosage for temporary relief of pain

Adult
  • Recommended: 500 mg - 1000 mg of Paracetamol with 150 mg - 300 mg of Ibuprofen every 6 hours
  • Maximum: 3000 mg of Paracetamol with 900 mg of Ibuprofen in one day

Minimum Age

18 years

Forms

Film-coated tablets
Strength: 500 mg/150 mg

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued. Avoid taking a repeated dose to make up for a missed one.

Overdose

What to do if you overdose on Flexon?
In the case of paracetamol poisoning, immediate medical treatment is given to overcome the risk of liver injury and emptying of the stomach (gastric lavage) should also be considered. For reversing the liver injury antidote therapy of acetylcysteine and methionine should be used as soon as possible. Acetylcysteine should be used within 8 hours of taking paracetamol overdose. Initially 150 mg/kg or 68.18 mg/lb of acetylcysteine in 200 ml 5% glucose is given through blood veins (intravenous or I. V. route) for 15 minutes, which is followed by intravenous infusion of 50 mg/kg or 22.7 mg/lb of acetylcysteine in 500 ml 5% glucose for 4 hours and 100 mg/kg or 45.45 mg/lb of acetylcysteine in 1 litre 5% glucose for 16 hours. Methionine is given orally as 2.5 g in every 4 hours interval up to 10 g. Methionine should only be used within 10 hours after taking paracetamol overdose. In the case of ibuprofen poisoning, the stomach should be emptied by lavage or vomiting. Activated charcoal should be used to absorb the excess amount of ibuprofen into the body. Ibuprofen is acidic in nature and excreted in urine so the excess amount of ibuprofen may be removed by using basic (alkali) drugs and inducing urine excretion (diuresis).
Symptoms of an overdose of Flexon
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
  • abnormal brain functioning (encephalopathy)
  • abnormal glucose metabolism
  • abnormal heartbeat
  • acidity
  • coma
  • convulsions
  • decreased brain functioning
  • decreased lungs functioning
  • dizziness
  • kidney damage or failure
  • liver failure or damage
  • loss of appetite (anorexia)
  • loss of consciousness
  • nausea
  • stomach (abdominal) pain
  • vomiting
If you think you have overdosed on Flexon Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Flexon

Before you use Flexon Tablet, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic any of the following substances: medicines containing aspirin, or NSAIDs (Non-steroidal Anti-inflammatory Drugs).
Before you use Flexon, tell your doctor of your medical and health history including the following: taking pain-killer (anti-inflammatory), warfarin, ticlopidine, phenytoin, chloramphenicol, probenecid, zidovudine, isoniazid, captopril, atenolol, losartan, digoxin, diuretics, lithium compounds, methotrexate, prednisolone, cortisone, metoclopramide, propantheline, tacrolimus, ciclosporin, sulphonyleureas, quinolone antibiotics, heart failure, chest pain (angina), heart attack, bypass surgery, poor circulation of blood in the legs or feet due to blockage of blood arteries (peripheral artery disease), stroke, mini-stroke, high blood pressure, diabetes, high cholesterol, family history of heart disease or stroke, smoking, liver disease, liver failure, liver swelling (hepatitis), kidney disease, kidney failure, difficulty in urination, heavy drinker, heartburn, indigestion, stomach ulcer, stomach problems, blood in vomiting, bleeding in stools, allergic skin reactions (Stevens-Johnson syndrome), asthma, vision problems, inflammation in bowel (ulcerative colitis or Crohn's disease), stomach and intestinal bleeding, swelling of feet or ankles, diarrhea, smallpox, heriditical genetic skin or neurological disorders (porphyria), inflammation in connective tissues (lupus erythematosus), or seizures. Use of ibuprofen in patients with a history of liver failure or abnormal liver functioning may cause severe reactions such as jaundice, fatal liver inflammation (fatal hepatitis) and allergic rashes (eosinophilia). Patients with a history of abnormal kidney, liver and heart functioning, elderly patients, patients taking diuretics and ACE inhibitors may develop the reduced functioning of the kidney. Using Flexon in patients with a history of seizure may cause an excess level of acids in the body (metabolic acidosis). Before having surgery during the use of Flexon, discuss with your doctor and dentist about the medicinal products you use including prescription/non-prescription/herbal medicines.
Flexon Tablet may cause rarely seizures in some people. If you perform any activities where a loss of consciousness may cause harm to you (or others), you should discuss with your doctor.
Consult with your doctor on the use ofFlexon Tabletduring pregnancy, or if you are planning to become pregnant. Flexon should not be used in first 6 months of pregnancy unless the potential benefits on medicine justify the possible risks to the fetus. It is not recommended in the last 3 months of pregnancy (third trimester).Flexon Tabletbelongs to the NSAID class of medicines. NSAIDs should not be taken after 29 weeks of pregnancy as these medicines may cause serious harm to the unborn baby. Consult with your doctor on the use ofFlexon Tabletduring breastfeeding. Paracetamol may pass into breast milk but not in high clinical amount. Therefore, Flexon may be given for short-term treatment during breastfeeding. Consult with your doctor on the use of Flexon Tablet, if you are trying to conceive. The use of Flexon may reduce fertility in women trying to have a baby. Do not use Flexon in women who are having problems with having a baby.
Avoid consuming alcohol together with Flexon. Drinking alcohol may cause liver damage.
This medicine may cause bleeding in the stomach. Regular use of tobacco and alcohol while using this medicine can increase your risk of bleeding. Discuss this aspect with your doctor if you smoke and drink alcohol regularly. This medicine may increase your sensitivity to sunlight. If this happens, use a sunscreen and cover your skin when you are outdoors. Limit your time in the sun. If you get a sunburn on your skin, consult with your doctor.
Flexon Tablet may cause increased incidence of side-effects in older patients. Elderly patients may see an increased risk of flatulence, constipation, stomach ulcer, stomach and intestinal bleeding (perforation or gastrointestinal hemorrhage), and vomiting of blood (melaena haematemesis).
Long-term use of Flexon may lead to liver damage and even cause liver failure which can be possibly fatal. Long-term use of paracetamol may cause uncurable kidney failure (end-stage kidney disease).

What precautions should be taken during Pregnancy and Nursing, and administering Flexon to Children or the Older Adults?

Pregnant Women

Contraindicated or Not Recommended
Warning: Flexon should not be used in first 6 months of pregnancy unless the potential benefits on medicine justify the possible risks to the fetus. Flexon is not recommended in the last 3 months of pregnancy (third trimester).

Breastfeeding

Precaution
Warning: Paracetamol may pass into breast milk but not in high clinical amount. Therefore, Flexon may be given for short-term treatment during breastfeeding.

Younger Adults Population

Contraindicated or Not Recommended
Warning: Flexon is not recommended for children under 18 years.

Older Adults Population

Precaution
Warning: The lowest effective dose of NSAIDs for the shortest possible duration should be used in elderly patients.

Flexon Side-effects

The following side-effects may commonly occur when using Flexon Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use ofFlexon Tabletmay cause the following side-effects:
  • abnormal visual (amblyopia)
  • abnormally heavy bleeding at menstruation
  • allergic reaction to an injection of foreign protein
  • bleeding from the nasal cavity (epistaxis)
  • blurred and/or diminished vision
  • burning or prickling sensation
  • coma
  • confusion
  • constipation
  • decreased hemoglobin and hematocrit
  • depression
  • dream abnormalities
  • drowsiness
  • emotional lability
  • excessive sweating
  • fatigue
  • feeling of discomfort
  • flatulence
  • inability to empty the bladder
  • increased aspartate aminotransferase
  • increased blood alkaline phosphatase
  • increased blood creatine phosphokinase
  • increased platelet count
  • inflammation and bleeding in the small blood vessels (Henoch-Schönlein vasculitis)
  • inflammation of the connective tissues (lupus erythematosus syndrome)
  • inflammation of the digestive tract (Crohn's disease)
  • inflammation of the linings of the brain (aseptic meningitis with fever)
  • inflammation of the optic nerve (optic neuritis)
  • insomnia
  • low blood sugar (hypoglycaemic reaction)
  • opposite effect of the drug (paradoxical stimulation)
  • psychomotor abnormality
  • purple-colored spots on the skin
  • redness and peeling of the skin (exfoliative dermatoses)
  • scotomata and/or changes in colour vision
  • stomach and intestinal bleeding (perforation or gastrointestinal hemorrhage)
  • stomach ulcer
  • swelling of the kidney tubules (interstitial nephritis)
  • swelling of the skin
  • swollen male breast tissue
  • thickened respiratory tract secretions
  • tremor
  • vertigo
  • vomiting of blood (melaena hematemesis)
The following severe side-effects may also occur when using Flexon Tablet:
  • metabolic and nutrition disorders
    Symptoms: body produces excessive quantities of acid (metabolic acidosis) low potassium levels
  • immune system disorders
    Symptoms: allergic reaction including skin rash
    If this happens, stop taking Flexon and contact your doctor as soon as possible.
  • liver and kidney disorders
    Symptoms: inflammation of the liver (hepatitis), yellowish of the skin (jaundice), liver failure, liver necrosis/liver injury, acute kidney injury (acute tubular necrosis), acute or long-term kidney failure body to excrete too much protein in the urine (nephrotic syndrome)
    Urgent medical attention should be required if these side effects occur.
  • heart disorders
    Symptoms: fast heartbeat, increased or decreased heartbeat, high blood pressure heart failure
    Urgent medical attention should be required if these side effects occur.
  • Symptoms: lack of granulocytes, blood deficiency (anaemia), body stops producing enough new blood cell (aplastic anaemia), abnormal breakdown of red blood cells (haemolytic anaemia), decrease in the number of leukocytes, low level of neutrophils, deficiency of red cells, white cells, and platelets (pancytopenia) excessive bruising and bleeding due to low levels of platelets
    Urgent medical attention should be required if these side effects occur.
  • nervous system disorders
    Symptoms: hallucinations, drug-induced movement disorders (extrapyramidal effects) convulsion
  • Symptoms: asthma, breathing difficulty wheezing
    If this happens, stop taking Flexon and contact your doctor as soon as possible.
  • skin disorders (possibly fatal)
    Symptoms: sun allergy (photosensitivity), skin allergic reaction caused by infection (erythema multiforme), life-threatening skin reaction (Stevens-Johnson Syndrome), life-threatening drug-induced skin reaction, hives, drug-induced allergic syndrome drug reaction with eosinophilia and systemic symptoms (DRESS syndrome)
    If this happens, stop taking Flexon and contact your doctor as soon as possible.
  • stomach and intestinal disorders
    Symptoms: sore or inflammation inside the mouth, inflammation of the colon (ulcerative colitis), stomach inflammation (gastritis), pancreas inflammation (pancreatitis), bleeding from the back passage, black sticky bowel motions (stools) bloody diarrhea
    If this happens, stop taking Flexon and contact your doctor as soon as possible.
Your doctor has prescribed this Flexon because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Flexon.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Flexon by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:

Side-effects in Older Adults

Following are the side-effects of this medicine in elderly patients:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
If this happens, stop taking Flexon and contact your doctor as soon as possible.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Women using Flexon

Women using Flexon are at an increased risk. The use of cyclo-oxygenase/prostaglandin synthesis inhibitor may affect ovulation, which may lead to interference infertility. The effect may be reversible on stopping the medicine.

Family history problems

Patients with family history problems including reduced activity or absence of lactase (galactose intolerance, the Lapp lactase deficiency) and abnormal absorption of glucose and galactose in the body are at an increased risk when using Flexon. This medicine should not be used in patients with galactose intolerance, Lapp lactase deficiency and abnormal absorption of glucose and galactose.

Active alcoholism (excessive alcohol consumption)

Patients with active alcoholism (excessive alcohol consumption) are at an increased risk when using Flexon. Such patients may have an increased risk of liver damage. This medicine should not be used in such patients.

Long-term therapy of corticosteroids

Patients using corticosteroid for long-term are at an increased risk when using Flexon. These patients may experience worsening of the disease or insufficient production of adrenal glands. Patients should have their treatment tapered slowly rather than stopping suddenly when Flexon therapy is added to the treatment regimen.

Heart-related events

Patients with heart problems such as chest pain, heart failure, poor circulation in the feet or legs due to narrowing or blockage of arteries, mini-stroke, transient ischaemic attack, uncontrolled high blood pressure, high blood sugar, smoking, high levels of lipids in the blood (hyperlipidemia), and taking ibuprofen at high doses are at an increased risk when using Flexon. The use of ibuprofen increases the risk of arterial thrombotic events such as stroke and heart attack. Non-steroidal anti-inflammatory drugs may cause the occurrence of high blood pressure, excess fluids build up inside the body (fluid retention), worsening of the existing high blood pressure and abnormal blood pressure response in patients taking antihypertensives with non-steroidal anti-inflammatory drugs. High dose of ibuprofen should not be used in patients with uncontrolled high blood pressure, heart failure, peripheral arterial disease, heart disease, and cerebrovascular disease. The lowest effective dose for the shortest duration should be given to patients with heart disease, high blood sugar, smoking and high levels of lipids in the body. Precaution should be taken in patients with high blood pressure, excess fluids build up inside the body, and heart failure. Regular monitoring of high blood pressure should be considered during starting therapy of non-steroidal anti-inflammatory drugs.

Severe skin reactions

Patients using non-steroidal anti-inflammatory drugs are at an increased risk when using Flexon. The use of non-steroidal anti-inflammatory drugs may cause skin-related adverse events such as redness and peeling of the skin (exfoliative dermatitis), life-threatening drug-induced skin reactions, and life-threatening skin reactions (Stevens-Johnson syndrome), which can be fatal. Patients should be advised for the symptoms of serious skin reactions. Such patients should also consult their doctor on the occurrence of a skin rash or others signs of an allergic reaction.

Asthma

Patients with shortness of breathing (asthma) or with acetylsalicylic acid sensitive asthma are at an increased risk when using Flexon. Flexon should not be used in patients with acetylsalicylic acid sensitive asthma and precaution should be taken in patients with shortness of breathing.

Eye-related problems and inflammation of the linings of the brain (aseptic meningitis)

Patients with inflammation of the connective tissues (systemic lupus erythematosus), other connective disorders or taking Flexon are at an increased risk. Flexon may cause harmful effects related to the eye such as visual disturbances or inflammation of the linings of the brain (aseptic meningitis) in such patients. Eye examination should be considered in patients with visual disturbances.

Urine Tests

Paracetamol may interfere in the determination of 5-hydroxyindoleacetic acid (5HIAA), which may cause false-positive results. Patients should avoid the use of paracetamol several hours before and during the sample collection of urine for the urine test.

Abnormal functioning of the liver

Patients with abnormal functioning of the liver, history of liver disease, inflammation of the liver (hepatitis), using paracetamol at higher doses, or using paracetamol or ibuprofen for long-term are at an increased risk when using Flexon. The use of ibuprofen or paracetamol at higher doses may cause liver damage, liver failure and can be possibly fatal. Also, ibuprofen may cause a minor and short-term effect on liver enzymes. Symptoms of severe liver reaction are yellowing of the skin (jaundice), fatal inflammation of the liver, and some systemic manifestations are rash, or an increased number of eosinophils (eosinophilia). Regular monitoring of liver function should be considered in such patients. Ibuprofen should be discontinued on the occurrence of systemic manifestations, worsening of abnormal liver tests, or if clinical symptoms and signs with liver disease develop.

Abnormal functioning of the kidney

Patients with abnormal functioning of heart, kidney or liver, difficulty in urination, elderly patients, dehydrated patients or taking diuretics (thiazides), angiotensin receptor antagonist or angiotensin-converting-enzyme inhibitor, and an anti-inflammatory drug (cyclooxygenase-2 inhibitors or nonsteroidal anti-inflammatory drugs) are at an increased risk when using Flexon. Accumulation of ibuprofen metabolites may occur in patients with abnormal functioning of the liver. Taking diuretics, angiotensin-converting-enzyme drugs or anti-inflammatory drugs at the same time may cause abnormal functioning of the kidney or harmful effects to the kidney such as swelling of the kidney tubules (interstitial nephritis), kidney failure, and excretion of excess protein in the urine (nephritic syndrome). Precaution is required in these patients when starting ibuprofen therapy. Dose adjustment along with monitoring of kidney parameter such as creatinine levels should be considered in such patients.

Elderly patients

Elderly patients taking Flexon for more than 10 days are at an increased risk. The use of ibuprofen may cause an increased risk of adverse effects such as stomach and intestinal ulcer, heart failure or abnormal functioning of the kidney in patients over 65 years. Monitoring of the condition is recommended in patients taking therapy for more than 10 days. Precaution should be taken in patients using ibuprofen.

Blood-related disorders (coagulation defects)

Patients with haemostatic defects, intrinsic coagulation defects or taking anticoagulation therapy are at an increased risk when using Flexon. Ibuprofen prevents blood clotting and the use of Flexon may prolong bleeding time in these patients. Precaution and regular monitoring of haematological system should be considered in patients with coagulation defects, using ibuprofen for long-term, and taking anti-coagulation therapy.

History of the stomach and intestinal disorders, varicella, and porphyria

Patients with a history of inflammation of the digestive tract (Crohn's disease and ulcerative colitis), buildup of natural chemicals such as porphyrin in the body (porphyria), chickenpox (varicella), stomach or intestinal bleeding or ulcer, taking non-steroidal anti-inflammatory drugs, or acetylsalicylic drugs are at an increased risk when using Flexon. Non-steroidal anti-inflammatory drugs may cause stomach and intestinal bleeding or ulcer, indigestion, stomach pain, heartburn, diarrhea or nausea. Precaution and lowest effective dose for the shortest duration should be considered in patients with the history of varicella, porphyria, and stomach/intestinal ulcer or bleeding when using medicine containing ibuprofen. Flexon should not be used on the occurrence of stomach and intestinal bleeding.

Interactions with Flexon

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Your doctor's guidelines may need to be followed while taking this medicine along with probenecid, which is used to treat pain, redness, and tenderness in joints (gout). When paracetamol is used with probenecid, it may interfere in the excretion and level of paracetamol in the blood.
Flexon Tablet interacts with antidepressants with anticholinergic properties, propantheline, cholestyramine, and narcotic analgesics, which are used to treat depression, excessive sweating, itching, and pain respectively. When paracetamol is used with antidepressants, propantheline, or with a narcotic analgesic, it may decrease the absorption of paracetamol. Cholestyramine also reduces the absorption of paracetamol when given within 1 hour period of paracetamol.
There may be an interaction of Flexon with metoclopramide, which is used in the treatment and prevention of nausea and vomiting. When paracetamol is used with metoclopramide, it may increase the absorption of paracetamol.
Flexon Tablet may interact with warfarin, which is used in the treatment of stroke. Ibuprofen may interfere with the bleeding time, increases the risk of severe and fatal bleeding in the stomach and intestinal tract. Dose reduction is recommended in patients using paracetamol with an anticoagulant for a longer time. Close monitoring is recommended when the use of ibuprofen is necessary for patients taking warfarin.
Special instructions need to be followed while taking this medicine along with hepatotoxic drugs (chloramphenicol) and anticonvulsant agents, which are used to treat bacterial infections and epileptic seizures respectively. When paracetamol is used with chloramphenicol, it may increase the level of chloramphenicol in the blood. The risk of paracetamol harmful effects is increased in patients taking hepatotoxic drugs or anticonvulsant drugs with paracetamol.
Your doctor's guidelines may need to be followed while taking this medicine along with antiepileptic drugs, which are used to treat seizures. Using antiepileptic drugs with Flexon interfere in the working of Flexon and vice versa.
Flexon Tablet interacts with corticosteroids, which are used to treat (inflammation of joints) arthritis. When ibuprofen is used with corticosteroids, it may increase the risk of stomach and intestinal bleeding.
Special instructions need to be followed while taking this medicine along with acetylsalicylic acid, which is used to treat pain, fever, or inflammation. When ibuprofen is used with acetylsalicylic acid, it may prevent the blood coagulation effect of the acetylsalicylic acid. Also, long-term use of ibuprofen may decrease the heart-protective effect of the acetylsalicylic acid. Patients should not use ibuprofen with acetylsalicylic acid.
There may be an interaction of Flexon with lithium, methotrexate and cardiac glycosides, which are used to treat depression, cancer, and heart failure respectively. When ibuprofen is used with these medicines, it may increase the level of lithium and cardiac glycosides in the blood. The clearance of the methotrexate and lithium is also decreased when ibuprofen is used with these medicines.
Flexon Tablet may interact with anti-tuberculosis drugs (isoniazid), zidovudine, and co-trimoxazole, which are used to treat tuberculosis, human immunodeficiency virus and bacterial infections. When paracetamol is used in patients taking zidovudine, co-trimoxazole, and isoniazid alone or with other anti-tuberculosis drugs, it may cause severe liver damage. When ibuprofen is used with zidovudine, it may increase the bleeding time.
Flexon Tablet may interact with angiotensin-converting-enzyme inhibitor, diuretics and beta blockers, which are used to treat high blood pressure. When ibuprofen is used with angiotensin-converting-enzyme inhibitor, diuretics, and beta blockers, it may cause excretion of sodium in the urine (natriuresis), increased potassium level in the blood (hyperkalemia), and reduces the blood pressure lowering effect of these medicines.
Flexon Tablet interacts with salicylates and other non-steroidal anti-inflammatory drugs, which are used to treat pain and stiffness of joints (arthritis). Using salicylates or other non-steroidal anti-inflammatory drugs with Flexon may interfere the working of Flexon and vice versa.
There may be an interaction of Flexon with antihypertensives, which are used to treat high blood pressure. Using antihypertensives with Flexon may interfere the working of Flexon and vice versa.
This page does not contain all the possible interactions of Flexon Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Interactions of Flexon by Severity

Severe

The following medicines are usually not to be taken together without consulting with your doctor or pharmacist.

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

When should Flexon be not used?

Allergic reactions

This medicine should not be used in patients who are allergic to Flexon, acetylsalicylic acid and other non-steroidal anti-inflammatory drugs. These patients may have the following symptoms if they use this medicine:
  • swelling of the face, lips or tongue
  • wheezing
  • shortness of breath
  • sudden or severe itching
  • skin rash
  • hives
  • sun allergy (photosensitivity)
  • skin allergic reaction caused by infection (erythema multiforme)
  • life-threatening skin reaction (Stevens-Johnson Syndrome)
  • life-threatening drug-induced skin reaction
  • allergic reaction to an injection of foreign protein
  • inflammation of the connective tissues (lupus erythematosus syndrome)
  • inflammation and bleeding in the small blood vessels (Henoch-Schönlein vasculitis)

Active alcoholism (excessive alcohol consumption)

This medicine should not be used in patients with active alcoholism (excessive alcohol consumption). Such patients may have an increased risk of liver damage.

Stomach (peptic) ulcer and stomach or intestinal bleeding

This medicine should not be used in patients with an active or a history of stomach ulcer and stomach or intestinal bleeding. Patients may have an increased risk of stomach and intestinal bleeding, ulcer, a rupture in the walls of stomach and intestine (gastrointestinal perforation). These patients may have the following symptoms if they use this medicine:

Severe heart failure, kidney failure or liver failure

This medicine should not be used in patients with severe heart failure, kidney failure or liver failure. These patients may have the following symptoms if they use this medicine:
  • excessive fluid build-up inside the body
  • decreased functioning of the kidney

Heart disease, blood vessel related brain disease or other active bleeding

This medicine should not be used in patients with heart disease, blood vessel related brain disease or other active bleeding.

Blood-formation disturbances

This medicine should not be used in patients with blood-formation disturbances.

Expired Medication

Taking a single dose of expired Flexon is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Flexon Tablet .
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