Why it's used

Sinegra Coated Tablet is used to treat the inability to keep an enlarged and rigid state of the penis during sexual activity. This condition is known as erectile dysfunction or ED. It is a prescription medicine. This medicine helps by relaxing muscles and therefore allowing the flow of blood into the penis. This helps a man to keep the penis in an enlarged and rigid state during sexual excitement.
Phosphodiesterase 5 Inhibitors
Sinegra belongs to a class of medicines called Phosphodiesterase 5 Inhibitors. Phosphodiesterase 5 (PDE5) inhibitors are a group of targeted therapy medicines that used to treat people with high blood pressure. PDE 5 inhibitors are also used to treat erectile dysfunction.

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How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Sinegra Coated Tablet. If you have any questions related to this medicine, ask your doctor or pharmacist. Eat this medicine as recommended by your doctor.
Sinegra Coated Tablet is eaten with or without food. Avoid taking this medicine with the high-fat meal as it may reduce the effectiveness of the medicine. Sinegra Coated Tablet is eaten around 1 hour before sexual activity. Sinegra is not effective in the absence of sexual arousal.

Typical Dosage

The typical dose of Sinegra is 50 mg once a day (not more than 100 mg in one day). The maximum adult dose of Sinegra is 100 mg in a day. It takes 1 hour for this medicine to start to work. This medicine is not known to be habit-forming.
This medicine should be used on an as-needed basis.

Talk to Your Doctor

Talk to your doctor if you develop new or worsening symptoms. Tell your doctor if decreased blood pressure, chest pain, nausea, dizziness, decrease or loss of hearing, have an erection lasting more than 4 hours, and have loss of vision in one or both eyes. If you have any kidney disease, a lower dose will be prescribed. If you have issues with the health of your liver, a lower dose will be prescribed by the doctor.
Your doctor may recommend a lower initial dose of this medicine to see the impact of this medicine on the body. Please follow your doctor's directions. Taking a higher dose of this medicine may increase the risk of side-effects. A lower dose of this medicine may be recommended to reduce the risk of side-effects. Older patients may see an increase in the incidence of side-effects with this medicine. As a result, a lower dose may be recommended for older patients.

Use in Children

The safety and effectiveness of using Sinegra Coated Tablet in children has not been established.

Possibly safe with Alcohol

Sinegra is known to be safe with alcohol.

Storage

You should store Sinegra Coated Tablet store at 15-30°C (59-86°F) temperature, away from excess moisture, and away from light. Store the medicine away from the reach of children and pets.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Sinegra Coated Tablet for conditions for which it was not prescribed. Do not give Sinegra Coated Tablet to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

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How to take Sinegra

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Sinegra depends on the following factors:
  • patient's age
  • patient's health
  • the health of the patient's liver
  • the health of the patient's kidneys
  • medicines recommended by your doctor
  • any other medicines in use
  • response to treatment

Sinegra Dosage

Dosage for erectile dysfunction

Adult
  • Recommended: 50 mg per day
  • Initial: 25 mg per day
  • Maximum: 100 mg per day
Older Adults (65 years or higher)
  • Recommended: 50 mg/day
  • Initial: 25 mg/day
  • Maximum: 100 mg/day

Minimum Age

18 years

Forms

Tablet
Strength: 25 mg, 50 mg and 100 mg

Special Instructions

Oral formulations
Use not more than one tablet in a day with or without meals.

Overdose

What to do if you overdose on Sinegra?
In case of overdose, standard supportive measures should be adopted.
If you think you have overdosed on Sinegra Coated Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Sinegra

Before you use Sinegra, tell your doctor of your medical and health history including the following:
  • bleeding disorder
  • blood circulation problems
  • cancer of blood cells (leukemia)
  • cancer of white blood cells (multiple myeloma)
  • chest pain (angina)
  • deformed penis shape
  • diabetes
  • eye disease
  • have had blockage of veins in the lungs (PVOD)
  • heart failure
  • high blood pressure
  • high cholesterol
  • history of heart surgery
  • kidney or liver disease
  • low blood pressure
  • palpitation
  • recently have had dehydration
  • red blood cells disorder (sickle cell anemia)
  • rigid state of the penis that lasts for more than 4 hours during sexual excitement (priapism)
  • severe vision loss
  • stomach ulcers
  • stroke
Before you use Sinegra Coated Tablet, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
The use of this medicine may change blood pressure. Patients with known history of heart disease or stroke should monitor their blood pressure.

Alcohol

Sinegra Coated Tablet is known to be safe with alcohol.

Use in Pregnancy

Sinegra Coated Tablet is not for use by women and hence pregnant women should not use this medicine.

Use while Breastfeeding

Women who are breastfeeding should not use this medicine.

Seizures

Sinegra Coated Tablet can make you feel sleepy. Be careful while driving, using machinery, or doing any other activity that needs you to be alert. The consumption of alcohol with Sinegra Coated Tablet can make you feel more sleepy. Sinegra Coated Tablet may cause seizures in some people. Discuss with your doctor if you perform activities where a loss of consciousness may cause you or others harm.

Side-effects in Older Patients

Sinegra Coated Tablet may increase side-effects in older patients.

What precautions should be taken during Pregnancy and Nursing, and administering Sinegra to Children or the Older Adults?

Pregnant Women

Contraindicated or Not Recommended
Warning: This medicine is not recommended for use in pregnant women.

Breastfeeding

Contraindicated or Not Recommended
Warning: This medicine is not recommended for use during breastfeeding.

Younger Adults Population

Contraindicated or Not Recommended
Warning: This medicine is not recommended for children.

Older Adults Population

Possibly Safe
Warning: A starting dose of 25 mg should be considered for older patients greater than 65 years.

Sinegra Side-effects

The following side-effects may commonly occur when using Sinegra Coated Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following severe side-effects may also occur when using Sinegra Coated Tablet:
  • Heart disease (palpitation, or heart attack) (possibly fatal)
    If this happens, contact your doctor right away and stop taking medicine.
  • Erections lasting more than 4 hours (known as, priapism) (permanent injury to the penis)
    Symptoms: painfully enlarged and rigid state of the penis for more than 4 hours
    If this happens, you should contact your doctor right away.
  • Sudden loss or decrease in hearing
    Symptoms: dizziness ringing in the ears
    The medicine should be discontinued and you should contact your doctor right away.
  • Sudden vision loss in one or both eyes
    The medicine should be discontinued and you should contact your doctor right away.
Your doctor has prescribed this medicine because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious cases of side-effects. This page does not contain a complete list of all possible side-effects.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Sinegra by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:

Mild Allergic Reactions

Following are the symptoms of mild allergic reactions to this medicine:
Consult with your doctor.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Non-Arteritic Anterior Ischemic Optic Neuropathy

Patients with NAION (non-arteritic anterior ischemic optic neuropathy) risk factors may face a sudden loss of vision in one or both eyes. This medicine should be used with caution and if a loss of vision occurs, the medicine should be discontinued.

Loss of Hearing

Usage of this medicine may cause a sudden decrease or loss of hearing, ringing in ears (tinnitus), and dizziness. If you experience any of these symptoms, you should should stop the use of the medicine.

Existing Heart Disease

Patients with any prior history of heart diseases may have a higher risk of heart attack. Such patients should use this medicine with caution.

Prolonged Erection

Some patients may have a prolonged erection lasting more than 4 hours, or a painful erection lasting more than 6 hours. In this happens, you should consult with your doctor immediately.

Low Blood Pressure

In patients using low blood pressure medicines and Sinegra together, the blood pressure can drop significantly. This can result in dizziness, lightheadedness, and fainting. Such patients should first establish a stable regimen for their low blood pressure medicines and then start at a lower dose for Sinegra.

Use of Ritonavir

In patients using Sinegra along with Ritonavir, it can result in decreased blood pressure, loss of consciousness, and prolonged erection. For such patients, lower dosage of Sinegra is recommended.

Other Erectile Dysfunction Medicines

The combined use of Sinegra with other erectile dysfunction medicines may result in further lowering of the blood pressure. Combined use of multiple erectile dysfunction medicines is not recommended.

Interactions with Sinegra

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Sinegra Coated Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Nitrates

Sinegra Coated Tablet may interact with organic nitrates or nitrites, which are used to treat chest pain and heart disease. Using Sinegra along with nitrates can result in harmful effects on the heart. Hence, organic nitrates or nitrites should not be used in combination with this medicine.

Alpha-Blockers

There may be an interaction of Sinegra with alpha-blockers, which are medicines used to lower the blood pressure and treat prostate enlargement in men. Using Sinegra with alpha-blockers can result in reduced blood pressure. In such cases, the patient should be given the lowest dose of Sinegra, which is 25 mg.

Calcium Channel Blockers

Sinegra Coated Tablet interacts with amlodipine, which is a medicine used to lower the blood pressure. Taking these two drugs together can result in an abnormal blood pressure. As a result, Amlodipine and Sinegra should be used together with caution.

CYP3A4 Inhibitors

Special instructions need to be followed while taking this medicine along with ritonavir and other CYP3A4 inhibitors, which are medicines used in the treatment of HIV/AIDS. When these two drugs are given together, CYP3A4 inhibitors cause the levels of Sinegra in the blood to increase several folds. A starting dose of 25 mg of Sinegra should be considered in patients taking CYP3A4 inhibitors.

Interactions of Sinegra by Severity

Severe

The following medicines are usually not to be taken together without consulting with your doctor or pharmacist.

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Sinegra be not used?

Allergic Reactions

This medicine should not be used in patients who are allergic to it. These patients may have the following symptoms if they use this medicine:

Nitrates, Used to Treat Angina

This medicine should not be used by patients who are taking organic nitrates or organic nitrites. This medicine should not be given with nitrates in any form due to its hypotensive effects.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Sinegra is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Sinegra Coated Tablet .
Erectile Dysfunction
Sexual Health
Sexual Problems in Men
Sexually Transmitted Diseases

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