Glioblastoma Multiforme

The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype)

Symptoms of Glioblastoma Multiforme

The following features are indicative of Glioblastoma Multiforme:
  • seizure
  • headaches
  • nausea
  • vomiting
  • memory loss
  • changes in personality
  • speech difficulty
  • drowsiness
It is possible that Glioblastoma Multiforme shows no physical symptoms and still is present in a patient.

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Common Causes of Glioblastoma Multiforme

The following are the most common causes of Glioblastoma Multiforme:
  • cause is unknown

Risk Factors for Glioblastoma Multiforme

The following factors may increase the likelihood of Glioblastoma Multiforme:
  • age between 60 and 80 years
  • exposure to radiation
  • family history
  • neurofibromatosis
  • Li–Fraumeni syndrome
  • tuberous sclerosis
  • Turcot syndrome
  • environmental factors

Prevention of Glioblastoma Multiforme

No, it is not possible to prevent Glioblastoma Multiforme.
  • unknown prevention

Occurrence of Glioblastoma Multiforme

Number of Cases

The following are the number of Glioblastoma Multiforme cases seen each year worldwide:
  • Rare between 10K - 50K cases

Common Age Group

Glioblastoma Multiforme most commonly occurs in the following age group:
  • Aged between 60-80 years

Common Gender

Glioblastoma Multiforme can occur in any gender.

Lab Tests and Procedures for Diagnosis of Glioblastoma Multiforme

The following lab tests and procedures are used to detect Glioblastoma Multiforme:
  • Magnetic resonance imaging (MRI) scan: Determine the location and size of a brain tumour
  • Neurological Examination: To check the vision, hearing, balance, coordination, strength and reflexes
  • Computed tomography (CT): To diagnose brain tumours
  • Tissue biopsy: To diagnose glioblastoma multiforme

Doctor for Diagnosis of Glioblastoma Multiforme

Patients should visit the following specialists if they have symptoms of Glioblastoma Multiforme:
  • Oncologist
  • Neurosurgeon

Complications of Glioblastoma Multiforme if untreated

Yes, Glioblastoma Multiforme causes complications if it is not treated. Below is the list of complications and problems that may arise if Glioblastoma Multiforme is left untreated:
  • urinary tract infections
  • surgical site hematomas

Procedures for Treatment of Glioblastoma Multiforme

The following procedures are used to treat Glioblastoma Multiforme:
  • Surgery: To remove the brain tumours
  • Radiation Therapy: To kill the tumour cells by emission of radiations
  • Chemotherapy: To kill tumour cells
  • Palliative treatment: To improve quality of life and to achieve a longer survival time
  • Targeted drug therapy: To block the abnormalities and kill the cancer cells

Time for Treatment of Glioblastoma Multiforme

While time-period of treatment for each patient may vary, below is the typical time-period for Glioblastoma Multiforme to resolve if treated properly under an expert supervision:
  • Disease cannot be treated but only maintained or effects reduced

Last updated date

This page was last updated on 2/04/2019.
This page provides information for Glioblastoma Multiforme.

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