Hypereosinophilic Syndrome

A rare myeloproliferative neoplasm characterized by a clonal proliferation of eosinophilic precursors resulting in persistently increased numbers of eosinophils in the blood, marrow and peripheral tissues. Since acute eosinophilic leukemia is at best exceedingly rare, the term eosinophilic leukemia is normally used as a synonym for chronic eosinophilic leukemia. In cases in which it is impossible to prove clonality and there is no increase in blast cells, the diagnosis of "idiopathic hypereosinophilic syndrome" is preferred. (WHO, 2001)

Symptoms of Hypereosinophilic Syndrome

The following features are indicative of Hypereosinophilic Syndrome:
  • atopic eczema
  • hepatosplenomegaly
  • skin lesions
  • difficulty breathing
  • abdominal pain
  • diarrhea
  • arthritis
  • speech impairment
  • visual disturbances
  • anemia

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Common Causes of Hypereosinophilic Syndrome

The following are the most common causes of Hypereosinophilic Syndrome:
  • myeloproliferative neoplasms
  • increased production of interleukin-5
  • genetic mutations in unknown gene

Other Causes of Hypereosinophilic Syndrome

The following are the less common causes of Hypereosinophilic Syndrome:
  • stress-induced suppression of adrenal gland function
  • chronic myelogenous leukemia

Risk Factors for Hypereosinophilic Syndrome

The following factors may increase the likelihood of Hypereosinophilic Syndrome:
  • males
  • age between 20-50 yrs
  • autoimmune disease
  • atopy
  • hypoadrenalism
  • tropical eosinophilia
  • cancer

Prevention of Hypereosinophilic Syndrome

Yes, it may be possible to prevent Hypereosinophilic Syndrome.

Occurrence of Hypereosinophilic Syndrome

Number of Cases

The following are the number of Hypereosinophilic Syndrome cases seen each year worldwide:
  • Rare between 10K - 50K cases

Common Age Group

Hypereosinophilic Syndrome most commonly occurs in the following age group:
  • Aged between 20-50 years

Common Gender

Hypereosinophilic Syndrome can occur in any gender.

Lab Tests and Procedures for Diagnosis of Hypereosinophilic Syndrome

The following lab tests and procedures are used to detect Hypereosinophilic Syndrome:
  • Blood testing: To detect autoimmune conditions
  • Allergy testing: To detect environmental or food allergies
  • Stool testing: Helps in detection of parasitic infections
  • Imaging testing: Helps in evaluation of condition of heart, abdomen and lungs

Doctor for Diagnosis of Hypereosinophilic Syndrome

Patients should visit the following specialists if they have symptoms of Hypereosinophilic Syndrome:
  • Hematologist

Complications of Hypereosinophilic Syndrome if untreated

Yes, Hypereosinophilic Syndrome causes complications if it is not treated. Below is the list of complications and problems that may arise if Hypereosinophilic Syndrome is left untreated:
  • endomyocardial fibrosis

Procedures for Treatment of Hypereosinophilic Syndrome

The following procedures are used to treat Hypereosinophilic Syndrome:
  • Splenectomy: Reduce the pain due to spleen enlargement

Alternative Medicine for Treatment of Hypereosinophilic Syndrome

The following alternate medicine and therapies are known to help in the treatment or management of Hypereosinophilic Syndrome:
  • Nutritional Supplements: To cope up with increase in eosinophil counts

Patient Support for Treatment of Hypereosinophilic Syndrome

The following actions may help Hypereosinophilic Syndrome patients:
  • Support and advocacy groups: Helps to connect with other patients and families and provide valuable services regarding symptoms of Hypereosinophilic syndrome

Time for Treatment of Hypereosinophilic Syndrome

While time-period of treatment for each patient may vary, below is the typical time-period for Hypereosinophilic Syndrome to resolve if treated properly under an expert supervision:
  • In 6 months - 1 year

Last updated date

This page was last updated on 2/04/2019.
This page provides information for Hypereosinophilic Syndrome.
Hypereosinophilic Syndrome

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