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A synthetic cyclic dinucleotide (CDN) and agonist of stimulator of interferon genes protein (STING), with potential immunoactivating and antineoplastic activities. Upon intratumoral (IT) administration, STING agonist MK-1454 binds to STING and activates the STING pathway, which promotes IKK-related kinase TANK-binding kinase 1 (TBK1) signaling and activates nuclear factor-kappa B (NF-kB) and interferon regulatory factor 3 (IRF3) in immune cells in the tumor microenvironment; this leads to the production of pro-inflammatory cytokines, including interferons (IFNs). Specifically, expression of IFN-beta (IFNb) enhances the cross-presentation of tumor-associated antigens by CD8alpha-positive and CD103-positive dendritic cells (DCs) to cytotoxic T-lymphocytes (CTLs). This results in a CTL-mediated immune response against tumor cells and causes tumor cell lysis

Symptoms of Insect bite

The following features are indicative of Insect bite:
  • redness
  • itching
  • swelling of the lips
  • swelling of eyelids
  • throat swelling
  • burning
  • numbness
  • tingling

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Common Causes of Insect bite

The following are the most common causes of Insect bite:
  • insect bites
  • bee stings
  • fleas stings
  • bed bugs stings
  • mosquito bites

Risk Factors for Insect bite

The following factors may increase the likelihood of Insect bite:
  • malaria
  • lyme disease

Prevention of Insect bite

Yes, it may be possible to prevent Insect bite. Prevention may be possible by doing the following:
  • using insect repellent
  • cover exposed skin
  • avoid bugs where staying
  • avoid perfumes
  • use caution when eating outdoors

Occurrence of Insect bite

Common Age Group

Insect bite can occur at any age.

Common Gender

Insect bite can occur in any gender.

Lab Tests and Procedures for Diagnosis of Insect bite

The following lab tests and procedures are used to detect Insect bite:
  • Blood test: To identify the disease transmitted by biting or stinging bugs

Complications of Insect bite if untreated

Yes, Insect bite causes complications if it is not treated. Below is the list of complications and problems that may arise if Insect bite is left untreated:
  • malaria
  • lyme disease
  • chikungunya
  • yellow fever
  • dengue fever
  • sleeping sickness
  • leishmaniasis

Patient Support for Treatment of Insect bite

The following actions may help Insect bite patients:
  • Join online support groups: Interact with people who are facing the problems related to insect bite

Is Insect bite Infectious?

Yes, Insect bite is known to be infectious.

Last updated date

This page was last updated on 2/04/2019.
This page provides information for Insect bite.
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