Skin Related Disorders
Patients who were using Hifenac P in the first month of treatment are at highest risk for these reactions. Serious skin reactions including redness and scaling of the skin have been reported rarely with the use of Hifenac P. There is a risk of severe liver damage when doses are higher than the recommended one. Discontinue the drug at the first sign of skin rash, mucosal lesions, or any allergic reaction. Perform liver function tests if liver damage is suspected.
Allergic reactions may occur without exposure to the drug with any of the NSAIDs
including Hifenac P.
Hifenac P use can block clumping of platelets
Patients with an abnormality of heart, liver or functioning of kidneys and elderly patients are at an increased risk while using this medicine. Precaution should be taken in patients who are at increased risk of suffering from conditions such as coagulation disorders, history of stomach ulcers
. Also from inflammation of the digestive tract, pregnancy
, and lactation
in the brain, skin or nerve problems having enzyme deficiency in the liver. Caution is also needed in patients on diuretic
or at risk of decreased blood volume. Patients receiving prolonged therapy should be monitored regularly for liver function, functioning of kidneys tests, and blood counts.
Patients suffering from or with a history of inflammatory lung disease are at an increased risk when using this medicine. Hifenac P have been reported to accelerate spasm of a bronchial smooth muscle in such patients. The patient should be cautious when using Hifenac P in patients suffering from or with a history of inflammatory lung disease.
Patient taking alcohol
(more than 3 drinks) every day, an adult taking a dose of more than 4000 mg in 24 hours are at an increased risk. Also, a child taking > 5 doses in 24 hours and if taken with other drugs containing paracetamol are at a higher risk when using these medicines. If paracetamol is taken more than the recommended dose, it can cause liver damage. Due to large doses of paracetamol allergic reactions such as swelling of the face, throat, and mouth, breathing difficulty, a rash may happen.
Heart and Brain Disorders
Patients with heart disease (e.g. high blood pressure, high level of cholesterol
, high sugar level, smoking
) are at an increased risk while using this medicine. Use of Hifenac P (at high doses and in long term treatment) may lead to a small increased risk of blood clot disorders (e.g heart attack or stroke
), fluid retention and swelling. Patients with uncontrolled high blood pressure, heart failure, established heart disease, peripheral arterial disease, or heart disease should be treated only after careful monitoring. The patient should be careful before starting long-term therapy in patients with risk factors for heart disease.
Stomach & Intestinal Disorders
Elderly patients, patients with a history of ulcer
or perforation) are at higher risk when using this medicine. There is a risk of stomach and intestine disorders, which can be fatal any time during treatment. Patients should be cautious when receiving Hifenac P in combination with oral corticosteroids
, antiplatelet agents, and SSRIs
. Monitoring patients with stomach-intestinal disorders, colon inflammation, or blood disorders as it may get worse. Patients who are at increased risk should start their treatment on a low dose and with protective agents. Therapy with Hifenac P should be discontinued if stomach and intestine bleeding
Mixed Connective Tissue Disorders
Patients with mixed connective tissue disorders including systemic lupus
) are at an increased risk when using this medicine. These patients may have a risk of inflammation of the brain linings.