Severe Allergic Reaction (Anaphylactic Reaction)
Patients who are on treatment with Kefta and allergic to beta-lactam antibacterials are at an increased risk when using this medicine. Such patients are more likely to have an increased risk of fatal allergic reactions. This medicine is not recommended for use in patients who are allergic to beta-lactam antibacterials. Discontinue the use of Kefta, if any allergic reaction occurs.
Diarrhea due to Bacterial Infection
Patients on treatment with antibacterials are at an increased risk when using this medicine. Such patients are more likely to develop mild diarrhea
to the fatal inflammation of the digestive tract. If there is an existence of Clostridium difficile-associated diarrhea, the ongoing antibiotic
treatment should be discontinued. Appropriate fluid and electrolyte management, supplementation with protein, antibiotic treatment of Clostridium difficile, and surgical evaluation should be employed as required.
Patients on treatment with antibacterials are at an increased risk to develop superinfection with fungal or bacterial microbes. If there is a possibility of fungal or bacterial superinfections, then discontinue or interrupt the treatment with Kefta.
Development of Drug Resistance
Patients who are on treatment with antibiotics
in the absence of a bacterial infection are at an increased risk to develop drug resistance. Antibiotics including Kefta should only be taken in the presence of confirmed bacterial infection.
Such patients should take Kefta with care because it contains aspartame.
Interference with Glucose Test
Patients on treatment with Kefta are at an increased risk for the false-positive result for glucose in the urine and a false-negative result for blood glucose. It is recommended to follow other alternative methods of testing such as glucose oxidase and hexokinase methods to determine blood glucose levels in patients receiving Kefta.
Patients while treatment with Kefta is at an increased risk to develop the reaction caused by harmful products released into the body after killing of microbes.
Interference with Diagnostic Tests
Use of Kefta may interfere with cross-matching compatibility of blood in between donor and recipient. It is recommended to follow other alternative methods of testing such as glucose oxidase and hexokinase methods to determine blood glucose levels in patients receiving Kefta.