Lyrica Capsule

Generic Name(s): Pregabalin

Why it's used

Lyrica Capsule is a prescription medicine that is used for the management of nerve pain associated with nerve damage due to uncontrolled high blood sugar (neuropathic pain associated with diabetic peripheral neuropathy) and nerve pain associated with nerve inflammation caused by infection (postherpetic neuralgia). This medicine works by decreasing the number of pain-inducing signals that are sent out by damaged nerves in the body.Lyrica Capsuleis also used to relieve neuropathic pain after spinal cord injury, and to treat widespread muscle pain and tenderness and certain types of seizures in adults and children.
Anti-epileptic Agent
Lyrica belongs to the Anti-epileptic Agent class of medicines. Antiepileptic drugs are a class of medicines which are used to treat epilepsy by controlling seizures.

How to use

Follow directions on the product label, information guide, and provided by your doctor before using Lyrica. Consume this medicine as per your doctor's instructions.
Lyrica is consumed with or without food. Lyrica should be swallowed whole and should not be split, crushed and chewed. Lyrica is consumed usually taken just after an evening meal. Taking Lyrica once daily after an evening meal may show similar levels of Lyrica in blood as compared to taking Lyrica twice daily without food.
The typical adult dose of Lyrica is 330-660 mg/day. The maximum dose for adults of Lyrica is 330-660 mg per day. Lyrica is typically used at the same time every day. Habit forming tendencies may sometimes be seen with this medicine. You may be at higher than normal risk if you have an addiction to alcohol, or to drugs. To reduce your risk of addiction, take this medicine exactly as prescribed.
This medicine should be used on an as-needed basis. You should continue to use this medicine as directed by the doctor even if you feel well.
Tell your doctor if you develop new or worsening symptoms. Talk to your doctor if depression, unusual changes in mood or behavior, thoughts about suicide or dying, insomnia, attempts to commit suicide, irritability, new or worse depression, acting aggressive, being angry, or violent, new or worse anxiety, acting on dangerous impulses, feeling agitated or restless, an extreme increase in activity and talking (mania), panic attack, and unusual changes in behavior or mood. If you have any kidney disease, kidney creatinine clearance is monitored in patients with abnormal functioning of the kidney, and according to the creatinine clearance rate, the dose of Lyrica is adjusted. Consult with your doctor before stopping the use of Lyrica Capsule.
To see the impact ofLyrica Capsuleon the body, your doctor may recommend a lower initial dose. Please follow your doctor's instructions carefully. A lower dose ofLyrica Capsulemay be recommended to reduce the risk of side-effects. Older patients may see an increase in the risk of side-effects. Hence, a lower dose may be recommended.
When stopping this medicine, it is possible that you may experience withdrawal symptoms such as insomnia, nausea, headache, anxiety, diarrhea, and increased seizure. You may need to gradually decrease the dose of this medicine before stopping.
The safety and effectiveness of using this medicine in children has not been established.
To decrease the possibility of side-effects, you might be recommended to use the extended-release form of this medicine by your doctor. The extended-release medicine helps in maintaining a steady level of the medicine in your body for a longer period of time. Do not crush or chew the medicine, unless indicated on the package or by your doctor.
Avoid drinking alcohol with Lyrica.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Lyrica Capsule for symptoms for which it was not prescribed. Do not giveLyrica Capsuleto others who may have similar symptoms as you. Self-medication can cause harm.
Store Lyrica Capsule at 20°C to 25°C (68°F to 77°F), away from moisture, and away from heat. Keep this medicine away from children and pets.

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How to take Lyrica

Your dose and how often you take Lyrica will depend on the following factors:
  • age
  • patient's health
  • the health of the patient's liver
  • response to the medicine

Lyrica Dosage

Dosage for nerve pain associated with nerve damage due to uncontrolled high blood sugar (neuropathic pain associated with diabetic peripheral neuropathy)

Adult
  • Initial: 165 mg/day as a single dose
  • Maximum: 330 mg/day as a single dose within 1 week

Dosage for nerve pain associated with nerve inflammation caused by infection (postherpetic neuralgia)

Adult
  • Initial: 165 mg/day as a single dose
  • Maximum: 330-660 mg/day within 1 week

Forms

capsule
Strength: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg
Extended release tablets
Strength: 82.5 mg, 165 mg, and 330 mg

Missed Dose

During consumption of capsules or the oral solution, if you forget to take a dose, then take the missed dose as soon as you remember it. However, if it is the time for the next dose, then the missed dose should be skipped, and the regular dosing schedule should be continued. Do not double your dose to make up for a missed dose. If the patients forgot to take an extended-release form of Lyrica after the evening meal, then they should take their usual dose before bedtime with snacks. If in case patients miss a dose of Lyrica before bedtime than they should take their usual dose with the morning meal.

Overdose

What to do if you overdose on Lyrica?
The unabsorbed portion of the drug in the stomach is eliminated by inducing vomiting and stomach emptying (gastric lavage). General supportive care includes the monitoring of vital signs such as body temperature, blood pressure, heartbeat, breathing rate should be considered.
If you think you have overdosed on Lyrica Capsule, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Lyrica

Before you use Lyrica Capsule, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
Before you use Lyrica, tell your doctor of your medical history including alcohol consumption, overuse of prescribed medicines, swelling of the eyes, face, lips, tongue, or throat, vision problems, heart failure, bleeding problems, low number of platelets, kidney disease, patients who undergone surgical dental procedures, or patients with mental disorders. Taking Lyrica in the patient with the history of drug abuse may develop tolerance, progressive increase strength of drug taking (drug escalation) and drug-seeking behavior. Rapid discontinuation of Lyrica may increase the seizures frequency in the patient taking Lyrica with a seizure disorder. Before having any surgery when using Lyrica, tell your doctor and dentist about all the medicinal products you use including prescription and non-prescription medicines, and any herbal supplements.
The use of this medicine may change creatine kinase in the blood. The use of Lyrica may cause muscle injury (rhabdomyolysis) and increased levels of creatine kinase in the body.
The use ofLyrica Capsulemay change platelet count. Decreased levels of platelets were observed in patients taking Lyrica treatment.
The use of this medicine may change PR interval. Patients taking more than or equal to 300 mg/day of Lyrica may develop an increased PR interval.
Avoid the consumption of alcohol with Lyrica Capsule. Drinking alcohol may cause movement and coordination problem in legs, arms and other body parts, and sleepiness.
Consult with your doctor on the use ofLyrica Capsuleduring pregnancy. Consult with your doctor on the use ofLyrica Capsuleduring breastfeeding. This medicine may pass into breast milk, so breastfeeding is not recommended during Lyrica treatment. Consult with your doctor on the use of Lyrica Capsule, if you are trying to conceive.
Lyrica Capsule can make you feel sleepy. Be careful while driving, using machinery, or doing any other activity that needs you to be alert. The consumption of alcohol withLyrica Capsulecan make you feel more sleepy.
Lyrica Capsule may increase side-effects in older patients.

What precautions should be taken during Pregnancy and Nursing, and administering Lyrica to Children or the Older Adults?

Pregnant Women

No Known Risk
Warning: It is unknown whether Lyrica may affect the unborn baby so consult with your doctor before taking Lyrica in pregnancy.

Breastfeeding

No Known Risk
Warning: Lyrica may pass into breast milk so consult with your doctor while breastfeeding an infant.

Younger Adults Population

Contraindicated or Not Recommended
Warning: Due to lack of safety and effectiveness data, Lyrica is not recommended for children.

Older Adults Population

Management or monitoring precaution
Warning: Proper adjustment of dose is required in elderly patients with abnormal functioning of the kidneys.

Lyrica Side-effects

The following side-effects may commonly occur when using Lyrica Capsule. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use ofLyrica Capsulemay cause the following side-effects:
  • abnormal coordination
  • abnormal dreams
  • abnormal ejaculation
  • abnormality of voluntary movement (dyskinesia)
  • abnormally low levels of thrombocytes
  • addiction
  • agitation
  • altered state of consciousness
  • artial or complete loss of muscle movement (hypokinesia)
  • blood clot formation in the vein (deep thrombophlebitis)
  • blood in the urine (hematuria)
  • bone marrow cancer (myelofibrosis)
  • chest pain
  • cloudy urine (urate crystalluria)
  • cognitive disorder
  • decrease in the number of leukocytes (leukopenia)
  • decrease taste sensitivity
  • decreased glucose tolerance
  • decreased prothrombin
  • deficit in memory (amnesia)
  • depressed level of consciousness
  • difficulty swallowing (dysphagia)
  • dysautonomia
  • excessive physical sensitivity (hyperesthesia)
  • facial pain
  • fainting
  • hallucinations
  • hyperactivity and inability to concentrate ( hyperkinesia)
  • inability to empty the bladder
  • inability to formulate language (aphasia)
  • increase in the number of eosinophils in the blood (eosinophilia)
  • increase in the number of platelets (thrombocythemia)
  • increase in the number of red blood cells (polycythemia)
  • increase in the number of white blood cells (leukocytosis)
  • increased neutrophil count
  • increased sensitivity to pain (hyperalgesia)
  • increased sex drive (increased libido)
  • infection of the lungs (pneumonia)
  • inflammation of the kidney (nephritis)
  • inflammation of the pancreas (pancreatitis)
  • involuntary muscle contractions (dystonia)
  • involuntary muscle jerk (myoclonus)
  • involuntary muscular movement (myokymia)
  • irritability
  • joint stiffness
  • kidney stone (kidney calculus)
  • lack of interest (apathy)
  • lack of red blood cell (anemia/hypochromic anemia)
  • low blood pressure
  • low blood pressure while standing up from a lying or sitting position
  • low muscle tone (hypotonia)
  • lung swelling
  • middle ear infection (otitis media)
  • motor abnormalities (cerebellar syndrome)
  • mucosal dryness
  • muscular rigidity (cogwheel rigidity)
  • nerve pain (sciatica)
  • pain in the coccyx or tailbone area (coccydynia)
  • painful or difficult urination
  • palpitations
  • presence of albumin in the urine (albuminuria)
  • presence of protein in the urine
  • psychomotor hyperactivity
  • red or purple discolored spots on the skin
  • reduced urination
  • retinal vascular disorder
  • severe pain due to damaged nerve (neuralgia)
  • sleep phase rhythm disturbance
  • slowness of movement (bradykinesia)
  • speech disorders
  • stomach pain
  • swelling around the eyes
  • swelling of the breast tissue (gynecomastia)
  • swelling of the face
  • swelling of the stomach
  • swelling of the tongue
  • swollen or enlarged lymph nodes
  • unfriendliness (hostility)
  • vaginal discharge (leukorrhea)
The following severe side-effects may also occur when using Lyrica Capsule:
  • nervous system disorders
    Symptoms: altered mental state (encephalopathy), movement disorder (extrapyramidal syndrome), disturbance in mental abilities (delirium), serious mental illness (delusions) coma
  • stomach and intestinal disorders
    Symptoms: lipase increased, increased creatine kinase levels partly or entirely blockage of the small or large intestine (intestinal obstruction)
  • suicidal behavior and ideation
    Symptoms: thoughts about suicide or dying, insomnia, attempts to commit suicide, irritability, new or worse depression, acting aggressive, being angry, or violent, new or worse anxiety, acting on dangerous impulses, feeling agitated or restless, an extreme increase in activity and talking (mania), panic attack unusual changes in behavior or mood
    Contact the doctor immediately if such symptoms occur.
  • heart disorders
    Symptoms: heart failure rapid heart beat
  • skin disorders (life-threatening respiratory function abnormality)
    Symptoms: life-threatening skin reaction (Stevens-Johnson Syndrome), presence of red blood cells in the urine, swelling of the face, swelling of the mouth swelling of the neck
    Use of Lyrica should be discontinued and contact the doctor immediately if such symptoms occur.
  • allergic reactions
    Symptoms: skin redness, blisters, hives, rash, trouble breathing (dyspnea) wheezing
    If any of these symptoms occur, discontinue the use of Lyrica and contact the doctor immediately.
Your doctor has prescribed Lyrica Capsule because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Lyrica Capsule.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Lyrica by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
If any of these symptoms occur, discontinue the use of Lyrica and contact the doctor immediately.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Swelling of the lower legs or hands

Patients using Lyrica alone or with thiazolidinedione antidiabetic agent are at an increased risk. These patients may experience higher frequencies of weight gain and swelling of the lower legs or hands, which may lead to heart failure. Such patients should be monitored for the occurrence of swelling of the skin when using Lyrica with thiazolidinedione antidiabetic agent. There are no sufficient studies of heart failure patients, these patients should be monitored for the worsening of heart failure.

Low levels of thrombocytes and heart block (PR Interval prolongation)

Patients using Lyrica are at increased risk. The use of Lyrica causes low levels of thrombocytes and heart blockage in such patients.

Increased level of creatine kinase in the blood (creatine kinase elevations)

Patients using Lyrica are at increased risk. The use of Lyrica may cause muscle injury (rhabdomyolysis) and increased levels of creatine kinase in the body. Tell your doctor immediately on the occurrence of tenderness, weakness, muscle pain, fever, and feeling of discomfort. Lyrica should be discontinued if (abnormality in muscle fiber) myopathy or increased level of creatine kinase in the blood occurs.

Eye-related effects (ophthalmological effects)

Patients using Lyrica are at increased risk. The use of Lyrica may cause vision-related events such as blurred vision in these patients. If this happens, contact your doctor right away. Frequent assessment should be considered in patients with persisting visual disturbance and in patients who are already examined for eye conditions.

Abrupt or rapid discontinuation of treatment with Lyrica

Patients with seizure disorders or who suddenly discontinue using this medicine are at increased risk. These patients may develop symptoms including diarrhea, headache, nausea, anxiety, seizures, and insomnia. Lyrica should not be discontinued suddenly rather it should be tapered slowly over a minimum of 1 week.

Weight gain

Patients using Lyrica are at an increased risk. The use of Lyrica may cause weight gain.

Dizziness and drowsiness

Patients using Lyrica alone or with other central nervous system drugs are at increased risk. The use of Lyrica may cause dizziness and drowsiness in these patients. The effects may worsen on combined usage of Lyrica with other central nervous system drugs. Patients should be informed about their weakened ability to perform tasks such as operating machinery or driving due to Lyrica related drowsiness and dizziness.

Suicidal behavior and ideation

Patients with epilepsy, other psychotic disorders or taking Lyrica are at increased risk. The use of Lyrica may increase the risk of suicidal behavior or thoughts, worsening of the depression, and unusual changes in behavior or mood changes in these patients. Carefully monitor the patients for the emergence or worsening of depression, suicidal thoughts and mood or behavioral changes.

Allergic reactions

Patients using Lyrica are at an increased risk of emergence of allergic symptoms. These patients may experience allergic reactions shortly after starting Lyrica therapy, which includes hives, wheezing, rash, difficulty in breathing (dyspnea), skin redness, and blisters. Lyrica should be discontinued immediately on the occurrence of the allergic reaction.

Swelling of the lower layer of skin

Patients with the previous episode of swelling of the lower layer of skin, using Lyrica, or drugs associated with swelling are at an increased risk. The use of Lyrica may cause swelling of the face, neck (larynx and throat), and mouth (tongue, gums, and lips) and abnormality in respiratory function (respiratory compromise) in these patients. Take necessary precautions while using Lyrica in patients with previous history of swelling of the lower layer of the skin.

Interactions with Lyrica

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Lyrica Capsule may interact with angiotensin-converting enzyme (ACE) inhibitors such as benazepril, captopril enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, and trandolapril which are used to treat high blood pressure. Using Lyrica with angiotensin-converting enzyme (ACE) inhibitors may cause swelling and hives. Talk to your doctor before start using these medicines with Lyrica.
There may be an interaction of Lyrica with rosiglitazone, metformin, pioglitazone which are used to treat diabetes. When Lyrica is used with these medicines, may lead to increased chances of weight gain or swelling in hands or feet. Talk to your doctor before start using these medicines with Lyrica.
Lyrica Capsule interacts with narcotic pain medicines such as oxycodon and antianxiety drugs such as lorazepam which are used to treat severe pain and anxiety disorder respectively. Using Lyrica with these medicines may increase the chance of movement and coordination problem in legs, arms and other body parts. It may also lead to sleepiness. Discuss with your doctor before start using these medicines with Lyrica.
Special instructions need to be followed while taking this medicine along with erythromycin which is used to treat bacterial infection. The combined use of Lyrica with erythromycin may decrease the levels of Lyrica in blood.
Your doctor's guidelines may need to be followed while taking this medicine along with gabapentin which is used to treat seizures and convulsions. The use of Lyrica with gabapentin may small decrease the absorption of Lyrica in the body.
Lyrica Capsule may interact with antidepressants, antihistamines which are used to treat depression and allergic reactions respectively. Talk to your doctor before taking these medicines with Lyrica. The doctor may change the dosage of medicines and monitor the patient for side-effects.
There may be an interaction of Lyrica with sedatives sleeping pills and tranquilizer, which are used to treat anxiety, fear, tension, sleep disturbances, and agitation. Consult with your doctor before taking these medicines with Lyrica. The doctor may change the dosage of medicines and monitor the patient for side-effects.
This page does not contain all the possible interactions of Lyrica Capsule. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Interactions of Lyrica by Severity

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Lyrica be not used?

Allergic to Lyrica

This medicine should not be used in patients who are allergic to it or any of its components. These patients may have the following symptoms if they use this medicine:

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Lyrica is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Lyrica Capsule .
Neuropathic Pain
What Is Diabetic Neuropathy?
Postherpetic Neuralgia
Seizures

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