Patients using aminoglycoside and Ampicillin+Cloxacillin together are at an increased risk. If these medicines are mixed in the same container, the loss of activity due to an infusion solution may occur. In such cases, these medicines should not be mixed in one container.
Long term use of Ampicillin+Cloxacillin may lead to overgrowth of resistant organisms.
Patients using antibiotics
are at an increased risk. These patients may suffer from mild to life-threatening swelling of the large intestine. It is necessary to observe the swelling of the large intestine in patients who suffer from diarrhea
while using or after the use of an antibiotic. Use of Ampicillin+Cloxacillin should be stopped and the patient is examined further if a long term or significant diarrhea or stomach cramps
The dose of Ampicillin+Cloxacillin should be adjusted in patients having a kidney problem.
Newborn babies having jaundice
are at high risk. Cloxacillin may relocate bilirubin from its protein binding sites. Ampicillin+Cloxacillin suspension and neonatal oral suspension containing sodium
benzoate may cause irritation to eyes, skin and mucous membrane. Cloxacillin should be used with caution in the treatment of jaundice in newborn babies.
Patients with a sodium-restricted diet
are at an increased risk. In these patients, the sodium
content of this medicine must be involved in their daily sodium diet allowance.
Oral Drops to Babies
Babies whose mothers are allergic to penicillin are at an increased risk while using Ampicillin+Cloxacillin neonatal oral drops
. Caution should be advised in such patients.
Prior Allergic Reaction
Careful monitoring should be conducted regarding prior allergic reaction to beta-lactam before starting Ampicillin+Cloxacillin treatment.
Penicillins and Cephalosporins Use
Patients using penicillin with cephalosporins are at high risk. Caution is advised in such patients.
Patients having allergy
from beta-lactam are at high risk. It is reported that patients taking beta-lactam antibiotics
may suffer from severe and irregular fatal allergic reactions. A severe allergic reaction is more likely to occur when penicillin is taken through injection as compared to oral therapy. The use of Ampicillin+Cloxacillin should be stopped and start a suitable alternative treatment if an allergic reaction occurs. Treat the side effects according to the symptoms.
Skin rash has occurred with a viral infection (mononucleosis
) or severe blood cancer
after the use of ampicillin. If these conditions may be suspected, avoid the use of ampicillin in such patients.