Why it's used

Ceftazidime is used to treat certain infections such as lower respiratory tract infections, skin infections, urinary tract infections, bone and joint infections, infections of the female reproductive system, long-term middle ear infection, life-threatening outer ear infection and infections within the stomach. This medicine is also used to treat life-threatening bacterial blood infection and inflammation of the membrane of the brain and spinal cord. It is a prescription medicine. This medicine works by preventing the formation of bacterial cell wall. It helps by killing the bacteria due to the breakdown of the cell membrane. Ceftazidime is also used for the management of abnormally low white blood cell count with fever due to bacterial infection. It is also used to prevent urinary tract infections during the operation of excessive growth of the prostate gland.
When not to use
Ceftazidime cannot be used to treat viral infections.
Cephalosporin Antibacterials
Ceftazidime belongs to a class of medicines called Cephalosporin Antibacterials. Cephalosporins are antibacterial medicines that kill bacteria by interfering with how bacteria build their cell walls.

How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Ceftazidime. If you have any questions related to this medicine, ask your doctor or pharmacist. Inject this medicine as recommended by your doctor.
The typical dose of Ceftazidime is 100-150 mg/kg/day (45.5-68.03 mg/lb/day) every 8 hours for injection and 2000 mg starting dose followed by 4000-6000 mg every 24 hours for infusion (not more than 9000 mg/day for injection). The usual dose for children is 30-50 mg/kg (13.7-22.7 mg/lb) injected directly into veins every 8 hours to a maximum of 6 g/day. This medicine is not known to be habit-forming.
This medicine should be used on an as-needed basis. This medicine may be prescribed for the long-term in case of complicated infections. You should continue to use this medicine as directed by the doctor even if you feel well.
Talk to your doctor if you develop new symptoms. Tell your doctor if watery stool, bloody stool, stomach cramps, and fever. If you have any kidney disease, a low dose of Ceftazidime is recommended in patients with abnormal functioning of the kidney.
If you are giving Ceftazidime to a child, be sure to use a product that is meant for children. Before giving this medicine to a child, use the child's weight or age to find the right dose from the product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
The injection form of the medicine may be used on the in the vein, or in the muscles. This injection is injected directly into veins for a period of 3 to 5 minutes. Ceftazidime injection is prepared by dissolving Ceftazidime in 50 or 100 ml of 5% dextrose injection or 0.9% sodium chloride injection or 0.45% sodium chloride injection as diluent. This solution can be kept for 12 hours at room temperature and three days under refrigeration. The unused portion should be discarded after four hours.
Your doctor may request that specific lab tests be performed before you start using Ceftazidime. You may need to have Antibiotic Susceptibility test. This test is done to help the doctor in selecting an appropriate antibacterial drug for treatment.
You should store Ceftazidime 15°C and 30°C (59°F and 86°F), and protect from light. Store the medicine away from the reach of children and pets.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Ceftazidime for conditions for which it was not prescribed. Do not give Ceftazidime to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

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How to take Ceftazidime

Your dose and how often you take Ceftazidime will depend on the following factors:
  • age
  • weight
  • patient's health
  • the health of the patient's liver
  • medicines recommended by the doctor
  • any other medicines being used

Ceftazidime Dosage

Dosage for lower respiratory tract infections

Adult (adults and children equal to or more than 40 kg (88.2 lb))
  • Recommended: 100-150 mg/kg/day (45.3-68.03 mg/lb/day) every 8 hours for injection and 2000 mg as a starting dose followed by 4000-6000 mg every 24 hours for infusion
  • Maximum: 9000 mg/day for injection
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 150 mg/kg/day (68.03 mg/lb/day) in three divided doses for injection and 60-100 mg/kg (27.2-45.3 mg/lb) starting dose followed by 100-200 mg/kg/day (45.3-90.7 mg/lb/day) for infusion
  • Maximum: 6000 mg/day for injection and infusion

Dosage for abnormally low white blood cell count with fever

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 2000 mg every 8 hours for injection and 2000 starting dose followed by 4000-6000 mg every 24 hours for infusion
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 60-100 mg/kg (27.2-45.3 mg/lb) starting dose followed by 100-200 mg/kg/day (45.3-90.7 mg/lb/day) for infusion
  • Maximum: 6000 mg/day for injection and infusion

Dosage for hospital acquired pneumonia

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 2000 mg every 8 hours for injection and 2000 starting dose followed by 4000-6000 mg every 24 hours for infusion
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 60-100 mg/kg (27.2-45.3 mg/lb) starting dose followed by 100-200 mg/kg/day (45.3-90.7 mg/lb/day) for infusion

Dosage for inflammation of brain and spinal cord membranes (meningitis)

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 2000 mg every 8 hours for injection and 2000 starting dose followed by 4000-6000 mg every 24 hours for infusion
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 150 mg/kg/day (68.03 mg/lb/day) in three divided doses for injection and 60-100 mg/kg (27.2-45.3 mg/lb) starting dose followed by 100-200 mg/kg/day (45.3-90.7 mg/lb/day) for infusion
  • Maximum: 6000 mg/day for injection and infusion

Dosage for life-threatening bacterial blood infection (Bacteraemia)

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 2000 mg every 8 hours for injection and 2000 starting dose followed by 4000-6000 mg every 24 hours for infusion
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 150 mg/kg/day (68.03 mg/lb/day) in three divided doses for injection and 60-100 mg/kg (27.2-45.3 mg/lb) starting dose followed by 100-200 mg/kg/day (45.3-90.7 mg/lb/day) for infusion
  • Maximum: 6000 mg/day for injection and infusion

Dosage for bone and joint infections

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 1000-2000 mg every 8 hours for injection and 2000 starting dose followed by 4000-6000 mg every 24 hours for infusion
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 100-150 mg/kg/day (45.3-68.03 mg/lb/day) in three divided doses for injection and 60-100 mg/kg (27.2-45.3 mg/lb) starting dose followed by 100-200 mg/kg/day (45.3-90.7 mg/lb/day) for infusion
  • Maximum: 6000 mg/day for injection and infusion

Dosage for skin infections

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 1000-2000 mg every 8 hours for injection and 2000 starting dose followed by 4000-6000 mg every 24 hours for infusion
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 100-150 mg/kg/day (45.3-68.03 mg/lb/day) in three divided doses for injection and 60-100 mg/kg (27.2-45.3 mg/lb) starting dose followed by 100-200 mg/kg/day (45.3-90.7 mg/lb/day) for infusion
  • Maximum: 6000 mg/day for injection and infusion

Dosage for infections within the stomach

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 1000-2000 mg every 8 hours for injection and 2000 starting dose followed by 4000-6000 mg every 24 hours for infusion
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 100-150 mg/kg/day (45.3-68.03 mg/lb/day) in three divided doses for injection and 60-100 mg/kg (27.2-45.3 mg/lb) starting dose followed by 100-200 mg/kg/day (45.3-90.7 mg/lb/day) for infusion
  • Maximum: 6000 mg/day for injection and infusion

Dosage for urinary tract infections

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 1000-2000 mg every 8 or 12 hours for injection
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 100-150 mg/kg/day (45.3-68.03 mg/lb/day) in three divided doses for injection
  • Maximum: 6000 mg/day for injection

Dosage for urinary tract infections during the operation of excessive growth of the prostate gland

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 1000 mg while induction of temporary loss of sensation and the second dose at the removal of the catheter

Dosage for long term middle ear infection

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 1000-2000 mg every 8 hours for injection
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 100-150 mg/kg/day (45.3-68.03 mg/lb/day) in three divided doses for injection
  • Maximum: 6000 mg/day for injection

Dosage for life-threatening outer ear infection

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 1000-2000 mg every 8 hours for injection
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 100-150 mg/kg/day (45.3-68.03 mg/lb/day) in three divided doses for injection
  • Maximum: 6000 mg/day for injection

Dosage for inflammation of the stomach wall membrane

Adult (adults and children equal to or more than 40 kg (88 lb))
  • Recommended: 1000-2000 mg every 8 hours for injection and 2000 mg starting dose followed by 4000-6000 mg every 24 hours for infusion
Children (aged more than 2 months and weighing less than 40 kg or 88 lb)
  • Recommended: 100-150 mg/kg/day (45.3-68.03 mg/lb/day) in three divided doses for injection and 60-100 mg/kg (27.2-45.3 mg/lb) starting dose followed by 100-200 mg/kg/day (45.3-90.7 mg/lb/day) for infusion
  • Maximum: 6000 mg/day for injection and infusion

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Injection in the muscle (Intramuscular injection)
Strength: 500 mg and 1000 mg
Injection in the vein (Intravenous injection)
Strength: 500 mg, 1000 mg, and 2000 mg

Special Instructions

Patients having creatinine clearance 50-31 ml/min and blood creatinine 1.7-2.3 mg/dl
Firstly, an initial dose of 1000 mg should be given. Then, a maintenance dose of 1000 mg every 12 hours as an intermittent infusion or a starting dose of 2000 mg followed by 1000-3000 mg every 24 hours as continuous infusion should be given to patients with abnormal functioning of the kidney (adults and children greater than or equal to 40 kg or 88.18 lb). A dose of 25 mg/kg every 12 hours as intermittent infusion should be given to children with abnormal functioning of the kidney (children less than 40 kg or 88.18 lb).
Patients having creatinine clearance 30-16 ml/min and blood creatinine 2.3-4.0 mg/dl
Firstly, an initial dose of 1000 mg should be given. Then, a maintenance dose of 1000 mg every 24 hours as an intermittent infusion or a starting dose of 2000 mg followed by 1000 mg every 24 hours as continuous infusion should be given to patients with abnormal functioning of the kidney (adults and children greater than or equal to 40 kg or 88.18 lb). A dose of 25 mg/kg every 24 hours as intermittent infusion should be given to children with abnormal functioning of the kidney (children less than 40 kg or 88.18 lb).
Patients having creatinine clearance 15-6 ml/min and blood creatinine 4.0-5.6 mg/dl
Firstly, an initial dose of 1000 mg should be given. Then, a maintenance dose of 500 mg every 24 hours as an intermittent infusion should be given to patients with abnormal functioning of the kidney (adults and children greater than or equal to 40 kg or 88.18 lb). A dose of 12.5 mg/kg every 24 hours as intermittent infusion should be given to children with abnormal functioning of the kidney (children less than 40 kg or 88.18 lb).
Patients having creatinine clearance less than 5 ml/min and blood creatinine more than 5.6 mg/dl
Firstly, an initial dose of 1000 mg should be given. Then, a maintenance dose of 500 mg every 48 hours as an intermittent infusion should be given to patients with abnormal functioning of the kidney (adults and children greater than or equal to 40 kg or 88.18 lb). A dose of 12.5 mg/kg every 48 hours as intermittent infusion should be given to children with abnormal functioning of the kidney (children less than 40 kg or 88.18 lb).
Patients on hemofiltration having creatinine clearance 0 ml/min
Firstly, an initial dose of 1000 mg either as a single dose or in divided doses should be given. Then, a maintenance dose of 250 mg as hemofiltration dose should be given to patients with ultrafiltration rate of 5 and 16.7 ml/min. A maintenance dose of 500 mg as hemofiltration dose should be given to children with an ultrafiltration rate of 33.3 and 50 ml/min.
Patients on hemofiltration having creatinine clearance 5 ml/min
Firstly, an initial dose of 1000 mg either as a single dose or in divided doses should be given. Then, a maintenance dose of 250 mg as hemofiltration dose should be given to the patients with ultrafiltration rate 5 ml/min and 16.7ml/min. A maintenance dose of 500 mg as hemofiltration dose should be given to the patients with ultrafiltration rate 33.3 ml/min and 50 ml/min.
Patients on hemofiltration having creatinine clearance 10 ml/min
Firstly, an initial dose of 1000 mg either as a single dose or in divided doses should be given. Then, a maintenance dose of 250, 500, 500 and 750 mg as hemofiltration dose should be given every 12 hours to patients with ultrafiltration rate (5, 16.7, 33.3 and 50 ml/min) respectively.
Patients on hemofiltration having creatinine clearance 15 ml/min
Firstly, an initial dose of 1000 mg either as a single dose or in divided doses should be given. Then, a maintenance dose of 250, 500, 500 and 750 mg as hemofiltration dose every 12 hours should be given to patients with ultrafiltration rate (5, 16.7, 33.3 and 50 ml/min) respectively.
Patients on hemofiltration having creatinine clearance 20 ml/min
Firstly, an initial dose of 1000 mg either as a single dose or in divided doses should be given. Then, a maintenance dose of 500, 500, 500 and 750 mg as hemofiltration dose should be given every 12 hours to patients with ultrafiltration rate (5, 16.7, 33.3 and 50 ml/min) respectively.
Patients on hemodialysis having creatinine clearance 0 ml/min
Firstly, an initial dose of 1000 mg either as a single dose or in divided doses should be given. Then, a maintenance dose of 500 mg as hemodialysis dose should be given every 12 hours to patients with ultrafiltration rate (0.5, 1.0, 2.0 liter/h) in the flow rate of 1.0 liter/h. A maintenance dose of 500, 500, and 750 mg as hemodialysis dose should be given every 12 hours to patients with ultrafiltration rate (0.5, 1.0, 2.0 liter/h) respectively in the flow rate of 2.0 liter/h.

Missed Dose

In case you miss an injection, take it as soon as you remember. Skip the injection, if its time for next dose. Do not take two injections at the same time to make up for the missed one.

Overdose

What to do if you overdose on Ceftazidime?
The patients should be carefully observed and provide supportive measures. In patients with kidney disease, Ceftazidime can be removed by artificial blood purifying techniques (hemodialysis or dialysis of the peritoneal cavity).
Symptoms of an overdose of Ceftazidime
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Ceftazidime, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Ceftazidime

Before you use Ceftazidime, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Discuss with your doctor if you are allergic to cephalosporin, penicillin, monobactams, or carbapenem.
Before you use Ceftazidime, tell your doctor of your medical history including penicillin allergy, monobactam allergy, carbapenem allergy, stomach and intestinal disease, or inflammation of the inner lining of the colon (colitis). The patient who has a severe allergy to penicillin, monobactam or carbapenem, may also be allergic to Ceftazidime. Before having any surgery, discuss with your doctor and dentist about medicines you use including prescription medicines, non-prescription medicines, and herbal supplements.
The use of Ceftazidime may change liver enzyme level. A temporary increase in one or more liver enzymes level (such as aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, gamma-glutamyl transpeptidase, and alkaline phosphatase) have been seen in the patients while using this medicine.
The use of this medicine may change blood cell count. The changes in the blood cell count (such as eosinophilia, leukopenia, neutropenia, deficiency of granulocytes in the blood, low levels of thrombocytes, and lymphocytosis) have been seen in patients while using this medicine.
The use of Ceftazidime may change prothrombin time. The use of Ceftazidime may result in decreased prothrombin activity. Patients suffering from kidney disease, liver disease, poor nutritional condition or receiving prolonged therapy are at increased risk while using this medicine. Therefore, the prothrombin time should be monitored in patients who are at risk, and vitamin K should be given if needed.
The use of this medicine may change creatinine level. A temporary increase in the blood creatinine level has been seen in the patients who are using this medicine.
The use of this medicine may change blood urea or blood urea nitrogen. Patients using Ceftazidime may experience a temporary increase in blood urea or blood urea nitrogen level.
Ceftazidime should be used only when required in patients who are pregnant or planning to become pregnant. There are no adequate and well-controlled studies of this medicine available in pregnant women. This medicine should be prescribed to pregnant women only if the potential benefit justifies the potential risk to the fetus. Ceftazidime should be used while breastfeeding only when required. This medicine may pass into breast milk in small quantity. Therefore, necessary precaution should be taken while using this medicine in women who are breastfeeding. Consult with your doctor on the use of Ceftazidime, if you are trying to conceive.
Ceftazidime can make you feel sleepy. Be careful, especially while driving, while using heavy machinery, or when doing any activity that needs you to be completely alert. The consumption of alcohol with Ceftazidime can worsen the sleepiness. Ceftazidime may cause seizures in some people. Hence, you should discuss with your doctor before performing any activities where a loss of consciousness may cause harm to you or others.
Older patients may have a higher incidence of side-effects when using Ceftazidime.
The long-term use of Ceftazidime may result in the overgrowth of resistant organisms. The patients are at increased risk of kidney damage and ear damage during prolonged therapy thus the functioning of kidneys should be regularly monitored.

What precautions should be taken during Pregnancy and Nursing, and administering Ceftazidime to Children or the Older Adults?

Pregnant Women

Only When Necessary
Warning: Use of this medicine is prescribed in pregnant women only if the potential benefit justifies the potential risk to the fetus.

Breastfeeding

Only When Necessary
Warning: The patient should take caution while taking this medicine.

Younger Adults Population

Possibly safe
Warning: 

Older Adults Population

Precaution
Warning: Some of the elderly patients can be at high risk while using this medicine. Ceftazidime is mainly excreted by kidney thus the risk of harmful effects is high in elderly with abnormal functioning of the kidney. An appropriate dose, as well as proper monitoring of the functioning of the kidney, is recommended in elderly patients.

Ceftazidime Side-effects

The following side-effects may commonly occur when using Ceftazidime. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
  • an increase in the type of white blood cells (eosinophilia)
  • diarrhea
  • drug-induced life-threatening reaction
  • fever
  • increased number of platelets in the blood (thrombocytosis)
  • inflammation at the injection site
  • inflammation of a vein (phlebitis)
  • inflammation of a vein related to blood clot (thrombophlebitis)
  • nausea
  • pain, burning or swelling at the injection site
  • rash
  • red raised itchy skin rash
  • redness of the skin (erythema multiforme)
  • severe allergic reactions (called as, Stevens-Johnson syndrome)
  • severe itching of the skin
  • skin rash with blister
  • stomach pain
  • swelling and redness along a vein
  • temporary elevations in liver enzymes
  • vomiting
Rarely, the use of Ceftazidime may cause the following side-effects:
  • DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms)
  • bad taste
  • chills
  • complications involving the central nervous system (neurological sequelae)
  • decreased flow of bile from the liver (cholestasis)
  • dizziness
  • false-positive test for urinary glucose
  • fatigue
  • feeling sick or being sick
  • fits
  • fungal infection (candidiasis)
  • headache
  • hives
  • increased blood creatinine
  • increased blood urea nitrogen
  • increased number of lymphocytes in the blood (lymphocytosis)
  • inflammation of the vagina (vaginitis)
  • muscle twitching and spasm (neuromuscular excitability)
  • prolonged blood clotting (prothrombin) time
  • skin peeling
  • stomach ache
  • swelling of the lymph glands or face
  • tingling sensation
  • transient elevations of blood urea
  • tremor
  • unpleasant taste in the mouth
The following severe side-effects may also occur when using Ceftazidime:
  • stomach and intestinal disorders
    Symptoms: diarrhea, inflammation of digestive tract (colitis) vomiting
    If this occurs, consult your doctor.
  • liver disorders
    Symptoms: yellow coloration of the eyes or skin, liver dysfunction including the decreased flow of bile (cholestasis), jaundice increased blood bilirubin (hyperbilirubinemia)
  • blood and lymphatic system disorders
    Symptoms: anemia due to the abnormal breakdown of red blood cells (hemolytic anemia), anemia due to decreased production of blood cells (aplastic anemia), decreased level of all blood cells (pancytopenia), low level of white blood cells (neutropenia, leukopenia), deficiency of granulocytes in the blood, decrease in the number of platelets red blood cells destroyed too quickly
  • central nervous system disorders
    Symptoms: seizures, flapping tremor (asterixis), brain disease (encephalopathy), coma, muscle twitching and spasm (neuromuscular excitability) muscle jerking (myoclonia)
  • severe allergic reactions
    Symptoms: skin rash with blister, fever, redness of the skin, itchy skin rash, severe itching of the skin, swelling of the mouth or face, difficulty in breathing, skin peeling, fatigue, increase in a type of white blood cells (eosinophils), drug induced life threatning reaction, severe allergic reactions (called as, Stevens-Johnson syndrome) redness of the skin (erythema multiforme)
    If this happens, contact your doctor immediately.
  • kidney problems
    Symptoms: swelling in the kidney tube (interstitial nephritis) acute kidney failure
  • immune system disorders
    Symptoms: life-threatening allergic reactions with symptoms such as tightening of muscles in the lungs (bronchospasm) or low blood pressure
Your doctor has prescribed this Ceftazidime because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Ceftazidime.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Ceftazidime by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:
  • DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms)
  • bad taste
  • candidiasis
  • chills
  • cholestasis
  • dizziness
  • false-positive test for urinary glucose
  • fatigue
  • feeling sick or being sick
  • fits
  • headache
  • increased blood urea nitrogen
  • increased serum creatinine
  • lymphocytosis
  • neurological sequelae
  • neuromuscular excitability
  • paresthesia
  • prolonged prothrombin time
  • skin peeling
  • stomach ache
  • swelling of the lymph glands or face
  • transient elevations of blood urea
  • tremor
  • unpleasant taste in the mouth
  • urticaria
  • vaginitis

Severe Side-effects

Following are the severe side-effects of this medicine:

Mild Allergic Reactions

Following are the symptoms of mild allergic reactions to this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
  • difficulty in breathing
  • fever
  • increase in a type of white blood cells (eosinophils)
  • skin peeling
  • skin rash with blisters
  • swelling of the mouth or face
If this happens, contact your doctor immediately.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Coombs' test, which is a test performed before blood transfusion

The use of Ceftazidime in patients undergone Coombs' test may cause false positive results and further leads to cross-matching of blood. Inform the person who takes a sample for coomb's test that you are using Ceftazidime.

Patients with controlled sodium diet

The patients with controlled sodium diet are at increased risk while using this medicine as the Ceftazidime powder for solution for injection or infusion contains sodium. The patients should take caution while using this medicine.

Limited range of antibacterial activity

Ceftazidime is effective against a limited range of bacteria. Also, Ceftazidime is susceptible to hydrolysis by some extended spectrum beta-lactamases. The existence of extended-spectrum beta-lactamases producing organisms should be taken into account when selecting Ceftazidime for treatment.

Overgrowth of non-susceptible organisms

The patients using Ceftazidime for a long term are at increased risk while using this medicine. The overgrowth of non-susceptible organisms (for example, enterococci and fungi) may occur in such patients while using this medicine. The treatment with Ceftazidime should be discontinued and provide other appropriate measures. The regular assessment of the patient's condition is needed.

Patients with abnormal functioning of the kidneys

Such patients are at increased risk while using this medicine. The use of this medicine in such patients can cause seizures, a flapping tremor (asterixis), brain disease (encephalopathy), coma, muscle twitching and spasm (neuromuscular excitability) and muscle jerking (myoclonia), life-threatening epilepsy without seizures (nonconvulsive status epilepticus). The careful monitoring and dose reduction of Ceftazidime is recommended in such patients.

Clostridium difficile associated diarrhea (CDAD)

The patients using antibacterial drugs are at increased risk while using this medicine. The use of Ceftazidime may cause mild diarrhea to possibly fatal colitis. Antibacterial agents alter the organisms present in the colon causing overgrowth of the Clostridium difficile bacteria. If Clostridium difficile associated diarrhea (CDAD) occurs discontinue the use of Ceftazidime. The suitable treatment for treatment of this kind of diarrhea includes an appropriate fluid and electrolyte management, protein supplementation, antibacterial drug treatment, and surgical evaluation as clinically indicated.

Severe allergy to Ceftazidime

Patients who are allergic to Ceftazidime and other cephalosporins are at an increased risk when using this medicine. Such patients may see an increased risk of occurrence of fatal allergic reactions. If an allergic reaction occurs, discontinue this medicine. The treatment of severe allergic reactions includes the use of epinephrine, antihistamines, corticosteroids, pressor amines, airway management and supply of oxygen or fluids in the veins.

Interactions with Ceftazidime

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Your doctor's guidelines may need to be followed while taking this medicine along with Fehling's solution, Benedict's solution, which are used for detecting sugar in urine. The use of Ceftazidime may lead to a false positive reaction for the presence of glucose in urine. The use of glucose tests based on enzymatic glucose oxidase reactions is recommended.
Ceftazidime interacts with chloramphenicol, an antibiotic which is used to treat bacterial infection. Chloramphenicol may cause an opposite effect to Ceftazidime especially when used for killing the bacteria. The use of Ceftazidime with chloramphenicol should be avoided.
There may be an interaction of Ceftazidime with potent diuretics (for example, furosemide) which is used to lower the amount of salt and water in the body, treat high blood pressure and glaucoma. When Ceftazidime is used in combination with potent diuretics, it may cause kidney damage in such patients. The use of Ceftazidime with potent diuretics without consulting the doctor is not recommended.
Ceftazidime may interact with aminoglycoside antibacterial drugs (for example, gentamycin, tobramycin), which are used to treat bacterial infection. Patients using Ceftazidime with aminoglycoside antibacterial drugs may negatively affect the functioning of the kidney. Such patients are at increased risk of kidney damage and ear damage. In such patients, the functioning of the kidney should be monitored carefully especially when high doses of the aminoglycosides or prolonged therapy is taken.
Special instructions need to be followed while taking this medicine along with oral contraceptives, which are used to prevent pregnancy. Ceftazidime may affect the microorganisms living in the digestive tract (gut flora), resulting in low estrogen reabsorption and decreased effectiveness of combined oral estrogen and progesterone contraceptives.
This page does not contain all the possible interactions of Ceftazidime. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Interactions of Ceftazidime by Severity

Severe

The following medicines are usually not to be taken together without consulting with your doctor or pharmacist.

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Ceftazidime be not used?

Allergic to Ceftazidime and other cephalosporins

This medicine should not be used in patients with known allergic reaction to Ceftazidime and other cephalosporins. These patients may have the following symptoms if they use this medicine:
  • severe skin itching
  • skin rash
  • fever
  • severe skin reaction
  • swelling of the lower layer of skin
  • life-threatening allergic reaction
  • difficulty in breathing
  • skin peeling
  • blisters on skin

Patients with history of severe allergy to Ceftazidime and other beta-lactam antibacterial agents

This medicine is not recommended to use in patients with the history of allergic reactions. Use of this medicine in patients with the history of severe allergy to Ceftazidime may lead to an increased risk of life-threatening allergic reactions (anaphylaxis).

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Ceftazidime is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Ceftazidime .
Bacterial Infections
Skin Infections
Urinary Tract Infections
Bone Infections

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