When two or more
medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a
Drug Interaction.
This page does not contain all the possible interactions of Clonazepam. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any
medicines without the approval of your doctor.
Clonazepam interacts with anticonvulsants (hydantoins,
phenobarbital,
clonazepam,
carbamazepine,
phenytoin, and
sodium valporate), which are used to treat
epilepsy. When Clonazepam is used with anticonvulsants, it may cause sedation, lack of interest (apathy), harmful effects, or epilepsy (absence status epilepticus). Also, it may increase the clearance of Clonazepam by decreasing the level of Clonazepam. Precaution should be taken and the risk should be kept in mind when using these medicines together.
Special instructions need to be followed while taking this medicine along with narcotics, non-barbiturate hypnotics, and barbiturates, which are used to treat
pain, sleeplessness, and
anxiety respectively. When
Clonazepam is used with narcotics, non-barbiturate hypnotics, or barbiturates, it may increase the calming effect (central nervous system depressant effect) of
Clonazepam on
brain.
Your doctor's guidelines may need to be followed while taking this medicine along with antianxiety, thioxanthene, and butyrophenones, which are used to treat
anxiety, mental or emotional conditions, and
schizophrenia respectively. When
Clonazepam is used with antianxiety, thioxanthene, or butyrophenones,it may increase the calming effect (central nervous system depressant effect) of
Clonazepam on
brain.
Clonazepam interacts with
amprenavir, which is used in the treatment of
human immunodeficiency virus infection. When
Clonazepam is used with amprenavir, it may increase the risk of slow or ineffective breathing and sedation.
Special instructions need to be followed while taking this medicine along with
cimetidine,
fluvoxamine,
disulfiram, and
ritonavir, which are used to treat
heartburn,
depression, alcoholism, and
human immunodeficiency virus infection respectively. When
Clonazepam is used with cimetidine, fluvoxamine, disulfiram, or ritonavir, it may increase the levels of
Clonazepam in the blood.
Your doctor's guidelines may need to be followed while taking this medicine along with
rifampicin and
levodopa, which is used to treat
tuberculosis and symptoms of movement disorders (Parkinson-like symptoms) respectively. When
Clonazepam is used with
rifampicin, it may
interfere in the metabolism of
Clonazepam. Also using Clonazepam with levodopa may decrease the effect of Clonazepam.
Clonazepam may interact with
moxonidine or
alpha-blockers, which are used to treat high blood pressure. When
Clonazepam is used with alpha-blockers or moxonidine, it may increase the blood pressure lowering and sedative effects.
There may be an interaction of
Clonazepam with antihypertensive drugs (angiotensin-converting
enzyme inhibitors,
beta-blockers, adrenergic neuron blockers,
hydralazine, angiotensin-II receptor antagonists,
calcium channel blockers,
clonidine,
methyldopa,
diazoxide,
diuretics,
minoxidil,
nitrates or
nitroprusside) which are used to treat high blood pressure. When
Clonazepam is used with antihypertensive drugs, it may increase the blood pressure lowering effect of these medicines.
Special instructions need to be followed while taking this medicine along with
mirtazapine and
lofexidine, which are used to treat
depression and withdrawal symptoms caused during stopping
opioids respectively. The sedative effects of
Clonazepam are increased when this medicine is used with
baclofen, mirtazapine, or lofexidine.
Clonazepam may interact with central nervous system depressants. When
Clonazepam is used with central nervous system depressants, it may increase the risk of severe sedation, slow and ineffective breathing and worsen of heart disease. Patients should not use both medicines together.