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Why it's used

Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate is used to treat moderate to severe airflow obstruction from the lungs (long term obstructive pulmonary disease). This medicine works by reducing the swelling and irritation in the air passages of the lungs. This medicine helps by controlling breathing difficulties.
When not to use
Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate cannot be used to treat asthma. Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate cannot be used to relieve acute breathing problem (bronchospasm).
Corticosteroid
Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is a prescription medicine that belongs to a class of medicines called Corticosteroid. Corticosteroids are medicines that are used to provide relief for inflammation in the body. They reduce swelling, redness, itching, and certain allergic reactions. They are often used to treat severe skin problems, asthma, and arthritis. Corticosteroids can have side-effects that are very serious as they are very strong medicines. How to use Read the medicine guide provided by your pharmacist, your doctor, or the medicine company. If you have any questions related to Prednisolone, ask your doctor or pharmacist. Use Prednisolone as per the instructions provided by your doctor. Prednisolone is used with food. To prevent irritation in the stomach and intestines. Swallow the whole tablet with or without water. Do not break, chew or split the tablet. Typical Dosage The typical dose of Prednisolone for adults is 10-60 mg a day depending on the specific disease and its severity. This medicine is generally used for a period of 3-10 days for asthma. This medicine is not known to be addictive or habit-forming. Prednisolone should be used as directed by the doctor even if you feel well, or even if you think that there is no need for you to use your medicine. If using the orally-disintegrating form of this medicine, make sure you do not consume any food or fluid 5 minutes before or after taking this medicine. Before taking the medicine out of the package, wash your hands thoroughly. Place the medicine on the tongue. Make sure you do not chew or swallow the medicine. You do not need to drink water after consuming the medicine. In certain cases, the medicine can taste slightly bitter. Also, ensure that you do not break or split the medicine. If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use. When used in the injection form, this medicine is given directly into muscles (intramuscular), joints (intra-articular), or around the body joints (periarticular route). Talk to Your Doctor Discuss with your doctor if your condition worsens. Consult with your doctor before stopping the use of Prednisolone. Your doctor may prescribe a lower starting dose of this medicine to understand the impact on the body. Please follow your doctor's recommendations. A lower dose of this medicine may be recommended to reduce the risk of side-effects. Older patients may see an increase in the incidence of side-effects. As a result, a lower dose may be recommended for older patients. When stopping this medicine, some patients may experience withdrawal symptoms like an insufficient production of steroid hormones (adrenal insufficiency), and low blood pressure. You may need to taper (gradually decrease) the dose of this medicine when stopping. Use in Children If you are giving Prednisolone to a child, be sure to use a product that is for use in children. Use the child's weight or age to find the right dose from the product package or medicine label. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation. Avoid licorice while using Prednisolone. Medicines may be recommended for uses other than those listed in the medicine guide. You should not use Prednisolone for conditions or symptoms for which it was not prescribed. Do not give Prednisolone to other people, even if they have the same conditions or symptoms that you have. The use of this medicine without the advice of a doctor may cause harm. Storage Follow storage instructions on the product package if available. Store Prednisolone at room temperature 20-25ºC (68-77ºF), away from moisture, and away from light. Store this medicine away from children and pets. Read more: What are the uses of Prednisolone? How to take Prednisolone Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Prednisolone depends on the following factors: patient's health the health of the patient's liver the health of the patient's kidneys medicines recommended by your doctor any other medicines in use herbal supplements consumed response to treatment Prednisolone Dosage Dosage for multiple sclerosis Adult Recommended: 200 mg/day for a week, followed by 80 mg/day every other day for one month Children Initial: 0.14 mg-2 mg/kg (0.06 mg-0.9 mg/lb of body weight) daily in 3-4 divided doses depending on the severity Dosage for nephrotic syndrome Children Recommended: 60 mg/m2 bsa/day given in three divided doses for 4 weeks and 40 mg/m2 bsa/day single dose should be given on alternate days for 4 weeks Dosage for asthma Children Recommended: 1-2 mg/kg (0.4-0.9 mg/lb of body weight) daily in single or divided doses for 3-10 day bursts Dosage for allergic and skin disorders Adult Initial: 5-15 mg/day Dosage for collagenosis Adult Initial: 20-30 mg/day Dosage for rheumatoid arthritis Adult Initial: 10-15 mg/daily Dosage for lymphoma Adult Initial: 15-60 mg/day Dosage for blood disorders Adult Initial: 15-60 mg/day Dosage calculation for children To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child. Forms Orally disintegrating tablets Strength: 10 mg, 15 mg, 30 mg Tablet Strength: 5 mg Suspension for Injection Strength: 25 mg/ml Syrup Strength: 15 mg/5 ml, 10 mg/3.3 ml, 7.5 mg/2.5 ml, 5 mg/1.6 ml Special Instructions Eye drops Shake the bottle well before use and avoid touching the dropper tip against the eye. Close your eyes for 2-3 minutes after inserting an eye drop. If you have poured more than one drop in the same eye, wait for at least 5 minutes before inserting the next drop. Eye ointment Thoroughly wash your hands with soap and water. Avoid contact of the tip of the tube against your eye. Generally, a 1/2-inch strip of ointment is used for the effectiveness, unless directed by your doctor. Close your eyes for 1 to 2 minutes to allow the medicine to be fully absorbed. Injection (intramuscular and intra-articular) The dose of intra-articular injection depends upon the size of the affected joints. Not more than three joints can be treated in a day. Similarly, the dosage of intramuscular injection depends upon the severe conditions of the disease and response to this medicine. Missed Dose A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued. Avoid taking a repeated dose to make up for a missed dose. Overdose What to do if you overdose on Prednisolone? If you have taken more than the recommended dose of Prednisolone, get medical treatment immediately. In the case of long-term intoxication, vomiting and cleaning out the contents of the stomach (gastric lavage) may help to reduce the toxic effects. Continuous steroid therapy is required to decrease overdose symptoms of Prednisolone. Symptoms of an overdose of Prednisolone If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include: abnormal enlargement of the liver abnormal fat deposits acne decreased blood potassium level decreased glucose tolerance decreased resistance to infection dry scaly skin excessive hair growth (hypertrichosis) fluid build up inside the body fractures headache high blood pressure increase in appetite increased heartbeat increased sweating inflammation of a vein due to the blood clot formation (thrombophlebitis) insufficient production of cortisol hormone (adrenal insufficiency) irregular periods (accentuated menopausal symptoms) low bone density (osteoporosis) menstrual disorders mental illness pain from nerve damage (neuropathy) skin coloration (pigmentation) skin discoloration (ecchymosis) skin marks during pregnancy (striae) stomach ulcer swelling of the abdomen (abdominal distention) thinning of scalp hair weakness weight gain If you think you have overdosed on Prednisolone, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com. Precautions while using Prednisolone Before you use Prednisolone, tell your doctor of your medical and health history including the following: a family history of diabetes abnormal functioning of kidneys chickenpox congestive heart failure epilepsy glaucoma high blood pressure liver failure measles patients with blood clotting disorders patients with hypothyroidism recurrent episodes of heart attack severe mood disorders stomach ulcers tuberculosis weakened immune system weakness in skeletal muscles women with weakened and brittle bones after menstruation Before you use Prednisolone, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Before having any surgery, discuss with your doctor and dentist about medicines you use including prescription medicines, non-prescription medicines, and herbal supplements. The use of Prednisolone may change intraocular pressure. Use of this medicine may increase the fluid pressure inside the eyes (intraocular pressure). The use of this medicine may change blood pressure. Use of this medicine may lead to an increase in blood pressure. The use of Prednisolone may change bone density. Use of this medicine leads to a decrease in bone density. Proper monitoring is required in patients who are receiving long-term corticosteroid treatment. The use of this medicine may change sodium, and potassium levels in the blood. Use of this medicine may increase sodium and potassium levels in the blood. Use when Pregnant Consult with your doctor on the use of Prednisolone during pregnancy or if you are planning to become pregnant. Use of Prednisolone during the first trimester of pregnancy may increase the risk of congenital abnormalities of mouth and lips, restricted growth of the fetus in uterus and decrease in birth weight. If Breastfeeding Consult with your doctor on the use of Prednisolone during breastfeeding. This medicine may pass into breast milk. Hence caution should be exercised when using Prednisolone while breastfeeding, especially when using it for a long period of time. If trying to Conceive Consult with your doctor on the use of Prednisolone, if you are trying to conceive. Seizures Prednisolone can make you feel sleepy. Be careful, especially while driving, while using heavy machinery, or when doing any activity that needs you to be completely alert. The consumption of alcohol with Prednisolone can worsen the sleepiness. Prednisolone may cause seizures in some people. Hence, you should discuss with your doctor before performing any activities where a loss of consciousness may cause harm to you or others. Increase in Risk This medicine may cause stomach bleeding. Regular use of tobacco or alcohol may increase the risk. Discuss with your doctor if you smoke and drink alcohol regularly. Prednisolone can increase your risk of getting infections/worsen existing infections. Reduce your chances of getting new infections by washing your hand regularly. Prevent cuts, bruises or injuries. Avoid people who may have infectious diseases. Avoid getting vaccinated. Corticosteroids may increase the risk of infection if you are suffering from chickenpox, measles and Strongyloides threadworm infestation (intestinal infection). Hence use this medicine with proper care in such patients. Side-effects in Older Patients Older patients may have a higher incidence of side-effects when using Prednisolone. Elderly patients may see an increased risk of high blood glucose level, high blood pressure, low potassium level in the blood, low bone density (osteoporosis), more exposure to infections, and skin thinning. Side-effects in Children Younger patients may have a higher incidence of side-effects with Prednisolone. Younger patients may see an increased risk of delayed growth and development. Long-term Use Use of this medicine for long-term may increase the risk of damage to the optic nerve (glaucoma), high blood pressure, low bone density, diabetes, low potassium levels in the blood, more exposure to infection and skin thinning particularly in elderly patients. In children, this medicine may lead to delayed growth and development. Read more: What precautions should be taken during Pregnancy and Nursing, and administering Prednisolone to Children or the Older Adults? Prednisolone Side-effects The following side-effects may commonly occur when using Prednisolone. If any of these side-effects worsen or last for a long time, you should consult with your doctor: behavioural and mood changes fluid buildup inside the body (fluid retention) glucose intolerance high blood pressure increased appetite problem with the excretion of sodium from the body (sodium retention) weight gain The following side-effects may commonly occur in older patients on the use of Prednisolone. Discuss with your doctor if any of these side-effects last for a long time or are severe: high blood glucose level high blood pressure low bone density (osteoporosis) low potassium level in the blood more exposure to infections skin thinning The following side-effects may commonly occur in children when using Prednisolone. Discuss with your doctor if any of these side-effects last for a long time or are severe: delay in growth and development (growth retardation) Rarely, the use of Prednisolone may cause the following side-effects: a small opaque or cloudy area on the backside of the lens (posterior subcapsular cataracts) abnormal fat deposits abnormally enlarged liver (hepatomegaly) acne bleeding in stomach and intestine bluish discoloration of skin due to trauma (ecchymose) decrease in carbohydrate tolerance disturbed blood flow due to fat deposits in the blood vessels (fat embolism) dry scalp emotional instability expended abdomen due to accumulated gas or fluid (abdominal distention) extreme happiness (euphoria) eye bulbing (exophthalmos) facial puffiness facial redness failure of heart circulation (circulatory collapse) fainting feeling of discomfort fluid build up in lungs fracture of long bones growth retardation in children headache heart enlargement hiccups improper wound healing inadequate pigmentation of the skin (hyper or hypopigmentation) increased liver enzyme levels in the blood increased pressure inside the eye increased pressure within or around the brain increased sweating inflammation of the pancreas (pancreatitis) inflammation of veins due to the blood clot formation (thrombophlebitis) insomnia loss of body balance (vertigo) loss of heart functioning (cardiac arrest) loss of muscle mass loss of sensation in foot and ankle (Charcot-like arthropathy) menstrual abnormalities mood changes moon-like face muscle weakness nausea negative nitrogen balance due to protein catabolism nerve inflammation (neuritis) pain caused by nerve damage (neuropathy) palpitation partial loss of function in lower body parts (paraparesis) personality changes red or purplish spots on the skin (petechiae) sensory disorders separation of tendon from body tissues (tendon rupture) skin rashes skin rashes with itchy and raised bumps skin thinning slow heart rate (bradycardia) spinal compression fractures stretch marks (striae) suppressed reactions to skin tests swelling in body parts thickening of heart muscles in premature babies (hypertrophic cardiomyopathy) thin fragile skin thinning of scalp hair tingling sensation unwanted hair growth on female body (hirsutism) weakened and brittle bones (osteoporosis) weight gain The following severe side-effects may also occur when using Prednisolone: Neurological diseases such as painful inflammation in the spinal cord (arachnoiditis), inflammation of the brain and spinal cord (meningitis) and nerve damage (neuropathy) Bleeding in stomach and intestines Life-threatening allergic reaction (anaphylaxis) Heart diseases such as heart attack, abnormal heartbeat, clot formation in the blood vessels (thromboembolism) and inflammation of the blood vessels (vasculitis) Your doctor has prescribed Prednisolone because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Prednisolone. If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com. Read more: Side-effects and Allergic Reactions of Prednisolone by Severity and Frequency Warnings Alterations in Endocrine Functioning Corticosteroids can cause hormone (hypothalamic-pituitary-adrenal axis) suppression and glucocorticosteroid insufficiency after withdrawal of treatment. This type of insufficiency may continue for months after discontinuation of therapy and can cause mineralocorticoid imbalance. Mineralocorticoid supplementation should be used to overcome the effects of corticosteroid therapy. Increased Risk of Infections Use of corticosteroids increases the risk of infections. The body's ability to fight new infections is reduced and existing infections may get masked. These infections include tubercolosis, chickenpox, measles, threadworm infestations, amebiasis and cerebral malaria. You should discuss with your doctor if you have a history, infection or exposure to any of these or other infections. Patients with Heart/Kidney Dysfunction Corticosteroids can increase blood pressure, salt or water retention, and also increases potassium and calcium secretion. Potassium supplementation and dietary salt restriction may be necessary for patients with high blood pressure, congestive heart failure, or kidney insufficiency. In such patients, these agents should be used with precaution. History of Stomach and Intestine Related Disorders Patients with a history of stomach and intestine related health problems are at a higher risk of getting holes in the stomach or intestines. Corticosteroids also mask signs if such an injury has already occurred. Behavioral and Mood Changes Prednisolone can cause behavioral and mood changes including depression, mood swings, insomnia, euphoria, and other personality changes. This medicine can also worsen existing behavioral problems. Consult with your doctor if you see such behavioral changes or have existing behavioral disorders to discuss the impact of this medicine. Risk of Osteoporosis Children, young adults and women who are undergoing or have undergone menopause are at a higher risk. Corticosteroids decrease bone formation because of decreased absorption and increased removal of calcium in the body. This increases the risk of osteoporosis in children, young adults and women who are undergoing or have undergone menopause. Impact on Eye Health Long term use of this medicine increases the risk of cataracts, glaucoma, damage to the optic nerves, and infections of the eye. Monitoring of the pressure in the eyes called as intraocular pressure should be performed if this medicine is used for more than 6 weeks. Avoid the use of Prednisolone if you have an eye infection called as ocular herpes simplex. Live or Live Attenuated Vaccines Such patients are at increased risk of developing complications because of a lack of immunity in the body. Live vaccines against smallpox (variola infection) should not be given to patients who are receiving immunosuppressive doses of corticosteroids. Development Problems in Children Long term use of Prednisolone is linked to negative effects on growth and development in children. Monitor for such effects especially if using this medicine for a long time. Use in Pregnancy Using this medicine during pregnancy or if you become pregnant when using this medicine may cause serious health issues in the unborn child. Such effects occur if this medicine is used during the first three months of the pregnancy. Neuromuscular Effects Patients using high doses of this medicine are at high risk of getting diseases related to the muscles (myopathy). Kaposi's Sarcoma Use of Prednisolone may cause cancer in soft tissues (Kaposi's sarcoma). Interactions with Prednisolone When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction. This page does not contain all the possible interactions of Prednisolone. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor. Antidiabetic Agents Your doctor's guidelines may need to be followed while taking this medicine along with antidiabetic agents, which are used to lower the blood glucose levels. In the case of diabetes, corticosteroids may increase the blood sugar level in the body. Dose adjustment is required in patients receiving anti-diabetic drugs. CYP3A4 Inducers Prednisolone interacts with CYP3A4 inducers (barbiturates, phenytoin, rifampin), which are used to treat certain diseases such as anxiety, depression, seizures, and tuberculosis. This combination may reduce the therapeutic effectiveness of corticosteroids by increasing the rate of metabolism. The dose of Prednisolone should be increased while using both drugs in combination. Immunosuppressants There may be an interaction of Prednisolone with cyclosporine, which is used to prevent organ rejection. The combined use of this medicine with Prednisolone may increase the effect of both drugs and may cause seizures. Proper adjustment of dose is required while using both the drugs in combination. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Prednisolone may interact with non-steroidal anti-inflammatory drugs (aspirin, salicylates), which are used to reduce pain, fever, and inflammation. The combined use of this medicine with corticosteroids may increase the risk of side effects related to stomach and intestine. This medicine should be used with precaution in patients with a rare blood disorder (hypoprothrombinemia). Anticoagulants Special instructions need to be followed while taking this medicine along with warfarin and other coumarins, which are used to prevent blood clot formation. The combined use of corticosteroids and warfarin usually prevents the response of warfarin. Coagulation parameters (prothrombin time) should be monitored to maintain the desired anticoagulant effect. Potassium-Depleting Agents Your doctor's guidelines may need to be followed while taking this medicine along with potassium-depleting agents (e.g., diuretics, amphotericin B), which are used to treat high blood pressure and fungal infections. The combined use of these medicines may increase the risk of low potassium level in the blood. Also, amphotericin B with corticosteroids may cause heart enlargement and heart failure. Anticholinesterase Agents Prednisolone interacts with anticholinesterase agents, which are used to treat neurodegenerative conditions such as dementia, Parkinson's disease, and Alzheimer's disease. The combined use of anticholinesterase agents and corticosteroids may cause severe weakness in the skeletal muscles. Anticholinesterase agents should be discontinued at least 24 hours before receiving corticosteroid treatment. Toxoids and Vaccines Special instructions need to be followed while taking this medicine along with toxoids and live or inactivated vaccines, which are used to treat certain viral infections like mumps, chickenpox, and measles. Long-term use of corticosteroids may decrease the response to toxoids and live or inactivated vaccines. Live vaccines should not be given to patients with the weakened immune system. CYP3A4 Inhibitors There may be an interaction of Prednisolone with ketoconazole, macrolide antibiotics, which are used to treat certain conditions like fungal, respiratory, Helicobacter pylori, sexually transmitted, and mycobacterial infections. Ketoconazole lowers the metabolism and may result in an increased risk of side effects of this medicine. The dosage of corticosteroids with such drugs should be reduced to avoid the potential side effects. Cardiac Glycosides Prednisolone may interact with digitalis, which is used to treat heart diseases such as heart failure and palpitation. This medicine may increase the risk of heart palpitation due to low levels of potassium in the blood. Antitubercular Drugs Prednisolone may interact with isoniazid, which is used for the treatment of tuberculosis. Prednisolone may decrease the levels of isoniazid in the blood. Aromatase Inhibitors Your doctor's guidelines may need to be followed while taking this medicine along with aminoglutethimide, which is used to treat certain diseases like seizures, breast cancer, prostate cancer, and Cushing syndrome. This combination may reduce the therapeutic effectiveness of corticosteroids by increasing the rate of metabolism. The dose of Prednisolone should be increased while using both drugs in combination. Oral Contraceptives Special instructions need to be followed while taking this medicine along with estrogens (oral contraceptives), which are used to reduce menopausal symptoms and prevents the pregnancy. This medicine may increase the effect of corticosteroids by decreasing its metabolism in the liver. Dosage adjustment may be required if estrogens are added to or withdrawn from this combination. Antivirals Prednisolone interacts with an antiviral drug (ritonavir), which is used to treat viral infection. This medicine increases the levels of Prednisolone in the blood. Cholesterol Lowering Agents There may be an interaction of Prednisolone with cholestyramine, which is used to lower the high levels of cholesterol in the blood. This medicine may increase the excretion of corticosteroids. Read more: Interactions of Prednisolone by Severity Brands Following are the top brand names of Prednisolone in countries around the world: Global Deltacortril, Prelone, Sintredius and Solone Australia Panafcortelone, Predmix, Predsolone and Redipred Canada Prednisocort Egypt Hostacortin H, Predsol Forte, Predsol, Solupred Oro and Xilone Hong Kong Panafcortelone 5, Prednis and Xepasone India Adred, Force, Pree, Sol, Solon and Wysolone Indonesia Lupred Nigeria P sone, Pericard, Predni, Prednisone and Solone Saudi Arabia Gupisone, Predo and Predo Singapore Deltasolone, Dhasolone, Prelone and Walesolone South Africa Aspelone, Capsoid, Lenisolone and Preflam UAE Isolone, Prednisolon Linz and Prednisolon Nycomed UK Pevanti, Prednisolone Dompe, Prednisolone and Soluble Prednisolone USA Cortalone, Delta-Cortef, Orapred Odt, Prednisolone Sodium Phosphate and Sterane Traveling With Medication Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids. While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website. Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor. If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time. Expired Medication Taking a single dose of expired Prednisolone is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines. Safe Disposal of Medication If there are disposal instructions on the package, please follow the instructions. If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events. If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container. If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step. 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How to use

Follow directions on the product label, information guide, and provided by your doctor before using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate. Inhale this medicine as per your doctor's instructions.

Typical Dosage

The typical adult dose of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is 92/55/22 micrograms (0.093/0.055/0.022 mg) once daily. The maximum dose for adults of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is 92/55/22 micrograms (0.093/0.055/0.022 mg) once daily per day. Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is typically used at the same time every day.
Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is to be used for longer periods of time. Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate may be prescribed for the long-term use for the treatment of symptoms of airflow obstruction (long term obstructive pulmonary disease). You should continue to use this medicine as directed by the doctor even if you feel well.

Talk to Your Doctor

Tell your doctor if your condition does not improve or worsens. Talk to your doctor if breathlessness, wheezing, cough, new or worse inability to completely empty the bladder, and new or worsening eye problems.
Taking a high dose of this medicine is known to increase the chances of side-effects.
When stopping this medicine, it is possible that you may experience withdrawal symptoms such as joint pain, muscular pain, physical or mental weariness (lassitude), and depression.

Use in Children

The safety and effectiveness of using this medicine in children has not been established.

Storage

Store Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate at 68-77°F (20-25°C), away from moisture, and away from light. Keep this medicine away from children and pets.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate for symptoms for which it was not prescribed. Do not give Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate to others who may have similar symptoms as you. Self-medication can cause harm.

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How to take Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate depends on the following factors:

Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate Dosage

Dosage for airflow obstruction from the lungs

Adult
  • Recommended: 92/55/22 micrograms (0.093/0.055/0.022 mg) once daily
  • Maximum: 92/55/22 micrograms (0.093/0.055/0.022 mg) once daily

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued. Avoid taking a repeated dose to make up for a missed dose.

Overdose

What to do if you overdose on Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate?
There is no specific antidote for the treatment of overdose. If overdose happens, the patient should be treated symptomatically (according to symptoms) and supportively. Heart function should be monitored in such patients. In the case of vilanterol overdose, cardioselective beta-blockade should be used in patients who are unresponsive to supportive therapy. Cardioselective beta-blockers should be used with precaution in patients with a history of breathing problems (bronchospasm).
Symptoms of an overdose of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate

Before you use Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate, tell your doctor of your medical and health history including the following:
  • asthma
  • bacterial, fungal or viral infection
  • bladder neck obstruction
  • bladder problem
  • build of acids in the blood (ketoacidosis)
  • convulsive disorder
  • enlarged prostate gland
  • excess thyroid hormone (thyrotoxicosis)
  • eye diseases
  • galactose intolerance, Lapp lactase deficiency and absorption abnormality of glucose-galactose
  • heart disease
  • high blood pressure
  • high blood sugar
  • immune system problem
  • liver problems
  • low levels of potassium
  • moderate to severe airflow obstruction from the lungs
  • taking atropine, Long-acting beta2-adrenergic agonists, beta blocker, clarithromycin, telithromycin, antifungal or anti-HIV, anticholinergics, tiotropium, indacaterol, and medicines that lower potassium levels
  • weak and brittle bones (osteoporosis)
Patients with weak and brittle bones may experience a reduction in bone mineral density when using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate. Patients with a history of eye problems may experience worsening of their condition when using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate. Patients with bacterial, fungal or viral infection may experience worsening of their infections. Patients with bladder neck obstruction or enlarged prostate gland may experience worsening of the inability to completely empty the bladder when using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate. Patients with the obstructive pulmonary disease are at an increased risk of pneumonia when using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate
Before you use Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Discuss with your doctor if you are allergic to milk protein.
Before having any surgery, discuss with your doctor and dentist about medicines you use including prescription medicines, non-prescription medicines, and herbal supplements.
The use of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate may change potassium level. Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate may decrease the level of potassium in patients with an abnormality in the functioning of the kidney.
The use of this medicine may change blood sugar level. Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate may increase the blood sugar level (hyperglycemia).
The use of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate may change low blood level. Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate may decrease the blood pressure level.
The use of this medicine may change Increased heartbeat. Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate may increase the heart rate.

Use when Pregnant

Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate should be used only when required in patients who are pregnant or planning to become pregnant. There are insufficient data for the use of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate in pregnant women. But during delivery or labor period Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate should be used only after considering the possible benefit to the mother and potential risk to the fetus.

If Breastfeeding

Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate should be used while breastfeeding only when required. A decision to discontinue Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate or to discontinue breast-feeding should be made after considering the benefit of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate to the woman and the benefit of breastfeeding for the child.

If trying to Conceive

It is not known if this medicine is safe for use in women who are conceiving. Consult with your doctor before you use Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate.

Increase in Risk

Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate can increase your risk of getting infections/worsen existing infections. Reduce your chances of getting new infections by washing your hand regularly. Prevent cuts, bruises or injuries. Avoid people who may have infectious diseases. Avoid getting vaccinated. This medicine may increase the risk of chickenpox and measles should be taken with care in patients with active or quiescent tuberculosis infection.

Long-term Use

Decreases in bone mineral density may occur in patients using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate for long-term. Also, optic nerve damage (glaucoma), cloudiness of the lens in the eye (cataracts), and increased intraocular pressure have been reported in patients suffering from moderate to severe airflow obstruction from the lungs using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate for long-term.

What precautions should be taken during Pregnancy and Nursing, and administering Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate to Children or the Older Adults?

Pregnant Women

Only When Necessary
Warning: There are insufficient data for the use of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate in pregnant women. But during delivery or labor period Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate should be used only after considering the possible benefit to the mother and potential risk to the fetus.

Breastfeeding

Only When Necessary
Warning: A decision to discontinue Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate or to discontinue breast-feeding should be made after considering the benefit of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate to the woman and the benefit of breastfeeding for the child.

Younger Adults Population

Contraindicated or Not Recommended
Warning: The safety and effectiveness of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate in children are unknown.

Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate Side-effects

The following side-effects may commonly occur when using Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate may cause the following side-effects:
The following severe side-effects may also occur when using Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate:
  • high cortisol level and reduced adrenal function (Possibly fatal)
    Symptoms: feeling tired, nausea and vomiting, lack of energy, low blood pressure weakness
    If such symptoms occur, appropriate therapy and particular care should be considered.
  • weakened immune system and increased chance of getting infections (immunosuppression) (Possibly fatal)
    Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate should be used with precaution in patients with existing immune system related infectious diseases. Inform the patients for worsening of fungal, bacterial, viral, or parasitic infections and tuberculosis etc.
  • respiratory disorders such as viral respiratory tract infection, and increased risk of infection of the lung (pneumonia)
    Symptoms: increase in mucus (sputum) production, chills, change in mucus color, increased cough, fever increased breathing problems
    Contact your doctor, If this happens.
  • heart disorders (possibly fatal)
    Symptoms: a fast or irregular heartbeat (supraventricular tachyarrhythmia/increased heartbeat/atrial fibrillation) increased blood pressure
    If this happens, stop taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate. This medicine should be used with precaution in patients with heart disorders.
  • worsening of eye problems such as glaucoma, narrow-angle glaucoma, and cataracts (If this happens, contact your doctor as soon as possible. Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate should be used with Precaution in patients with eye problems.)
    Symptoms: blurred vision, eye pain or discomfort, seeing halos or bright colors around lights, nausea or vomiting, red eyes eye swelling
  • difficulty in breathing (paradoxical bronchospasm)
    If this happens, stop taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate and alternative therapy should be considered.
  • inability to completely or partially empty the bladder
    Symptoms: difficulty urinating, urinating frequently, urination in a weak stream or drips painful urination
    If this happens, stop taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate and contact your doctor as soon as possible.
  • high levels of blood sugar | low levels of potassium |
  • serious allergic reactions
    Symptoms: rash, swelling of the face, mouth, and tongue, hives breathing problems
    If this happens, stop taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate and contact your doctor as soon as possible.
Your doctor has prescribed this Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
If this happens, stop taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate and contact your doctor as soon as possible.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Asthma-related Fatality

Patients taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate are at an increased risk. These patients may experience asthma-related fatality. Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate should not be used in the treatment of asthma.

Long-acting Beta 2-agonists

Patients taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate are at an increased risk. The use of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate with long-acting Beta2-agonists may result in heart disease and fatality. Patient should not use Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate with another medicine containing long-acting beta2-agonists such as salmeterol, formoterol.

Infection of Mouth and Pharynx

Patients taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate are at an increased risk. The use of fluticasone furoate may cause infection of the mouth, pharynx with oral thrush. Patients are advised to rinse their mouth with water prior to inhalation of the Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate without swallowing when such an infection develops, it should be treated with appropriate local or systemic antifungal therapy.

Respiratory Tract Infection

Patients taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate are at an increased risk. Patients may experience pneumonia, worsening of conditions (exacerbation) and lower respiratory tract infection while using the Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate. Patients with lung disease should take care use of this medicine.

Immunosuppression

Patients with active bacterial infection of the lung (tuberculosis), fungal, viral, parasitic infections, and ocular herpes simplex are at more risk. Use of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate in children or adults are more likely to risk of chickenpox and measles. Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate should be used with precaution in such patients.

Abnormal Production of Cortisol Hormone

Patients taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate are at an increased risk. The use of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate with a combination of strong cytochrome P450 3A4 and exceeding the recommended dose may result in abnormalities in the functioning of the hypothalamus, adrenal and pituitary gland such as abnormal production of cortisol hormone (hypercorticism and adrenal suppression). Proper care should be taken in postoperatively and stress patient for any inadequate adrenal response. If such symptoms occur, appropriate therapy should be recommended.

Cytochrome P450 3A4 Inhibitors

Patients taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate with strong CYP3A4 inhibitors are at greater risk. Patient may experience increased systemic corticosteroid and heart effects.

Breathing Problems

Patients taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate are at greatEr risk. These patients are more likely to side effect of breathing or wheezing problem which may be life-threatening. The Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate should be discontinued immediately and alternative therapy should be instituted.

Allergic Reactions

Patients taking powder medicine like lactose are at increased risk. These patients may experience side effects like anaphylaxis, swelling of the skin, rash, hives and also severe milk protein allergy. Patients with a severe milk allergy should not use this medicine.

Heart Problems

Patients with high blood pressure, heart disease taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate at increased risk. These patients may likely to have side effects such as abnormal heartbeat, increase in pulse rate and systolic or diastolic blood pressure. Discontinue the use of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate in such patients.

Bone Mineral Density

Patients with risk factors of decreased bone mineral content, such as poor nutrition, prolonged immobilization, family history of postmenopausal status, osteoporosis, tobacco use, advanced age, or long term use of drugs decreasing bone mass (e.g. oral corticosteroids and anticonvulsants) are at an increased risk when using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate. Patients with long term use of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate may have increased risk of reduction of bone mineral density level.

Eye Defects

Patient using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate for a long term are at increased risk. Patient may experience eye pain, blurred vision, visual halos or colored images and swelling of the cornea. Patient should consult a healthcare provider immediately if any of these signs or symptoms develop.

Inability to Completely Empty the Bladder

Patient taking Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate with prostate gland enlargement or obstruction of urinary flow are at increased risk. These patients may have difficulty in passing urine and painful urination.

Concurrent conditions

Patients with a convulsive disorder or thyroid problem using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate are at increased risk. These patients may increase blood sugar level and ketoacidosis.

Interactions with Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Inhibitors of Cytochrome P450 3A4

Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate may interact with inhibitors of cytochrome P450 3A4 (ketoconazole, ritonavir, and clarithromycin). When Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is used with inhibitors of cytochrome P450 3A4, it may increase the level of vilanterol and fluticasone furoate which may lead to increased heart-related blood vessels adverse effects. Precaution and monitoring of the adverse effects of corticosteroid should be considered in such patients. Both medicines should not be used together unless the benefits are more than the increased risk of corticosteroids.

Tricyclic Antidepressants

There may be an interaction of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate with tricyclic antidepressants (monoamine oxidase inhibitors), which are used to treat depression. When Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is used with tricyclic antidepressants, monoamine oxidase inhibitors, or with drugs known to prolong QT interval, it may increase the effect of these drugs on heart-related blood vessel system such as increased heart rate. Precaution should be taken in such patients.

Beta-Adrenergic Receptor Blocking Agents

Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate interacts with beta-adrenergic receptor blocking agents, which are used to treat abnormal heart rhythms. When Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is used with beta-adrenergic receptor blocking agents, it may decrease the effect of beta-adrenergic agonists and may cause narrowing of the bronchi (bronchospasm) in patients with moderate to severe airflow obstruction from the lungs. Beta-blockers should not be used in such patients. In some cases, cardioselective beta-blockers can be used cautiously.

Non–Potassium-Sparing Diuretic

Special instructions need to be followed while taking this medicine along with non–potassium-sparing diuretics (loop or thiazides diuretics), which are used to treat high blood pressure. When Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is used with non-potassium-sparing diuretics, it may decrease the level of potassium or may cause heart-related effects (electrographic). These effects may be worsened when beta-agonists are used more than the recommended dose. Precaution should be taken when using both medicines together.

Methylxanthine derivatives

Your doctor's guidelines may need to be followed while taking this medicine along with methylxanthine derivatives, which are used in the treatment of asthma. When Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is used with methylxanthines, it may potentiate the potassium-lowering effect of beta-agonist. Precaution should be taken when using both medicines together.

Steroids

Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate may interact with steroids, which are used to treat pain and stiffness of the joints. When Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is used with steroids, it may potentiate the potassium-lowering effect of beta-agonist. Precaution should be taken when using both medicines together.

Anticholinergics

There may be an interaction of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate with anticholinergics, which are used to treat diarrhea. When Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is used with anticholinergic, it may produce an additive effect which may lead to anticholinergic side effects such as an inability to completely or partially empty the bladder. Symptoms are difficult in passing urine or painful urination. Also, optic nerve damage (glaucoma), cloudiness of the lens in the eye (cataracts), and increased intraocular pressure have been reported in patients suffering from moderate to severe airflow obstruction from the lungs and using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate with inhaled anticholinergics. Symptoms of acute narrow-angle glaucoma are blurred vision, red eyes with colored images, conjunctival congestion, swelling of the cornea, and vision problems (visual halos). Patients should consult the doctor on the occurrence of such signs and symptoms of inability to completely or partially empty the bladder and glaucoma. Patients should not use Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate with anticholinergics agents.

Antimuscarinic Antagonists

Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate interacts with antimuscarinic antagonists, which are used to treat asthma. When Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is used with antimuscarinic antagonists, it may increase the occurrence of adverse effects. Patients should not use both medicines together.

Long-Acting Beta-2 Adrenergic Agonists

Special instructions need to be followed while taking this medicine along with long-acting beta-2 adrenergic agonists, which are used to treat asthma. When Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is used with long-acting beta-2 adrenergic agonists, it may increase the occurrence of adverse effects. Patients should not use both medicines together.

Interactions of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate by Severity

Severe

The following medicines are usually not to be taken together without consulting with your doctor or pharmacist.

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

When should Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate be not used?

Severe Allergy to Milk Proteins

This medicine should not be used in patients severely allergic to milk proteins. Patients may experience a life-threatening allergic reaction (anaphylactic reaction).

Allergic to Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate

This medicine should not be used in patients allergic to Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate. Patients may experience a life-threatening allergic reaction (anaphylactic reaction). These patients may have the following symptoms if they use this medicine:
  • serious allergic reaction (anaphylaxis)
  • swelling of the lower layer of the skin
  • rash
  • hives

Asthma

This medicine should not be used in patients suffering from asthma. These patients may experience an increased risk of fatality due to asthma problems.

Breathing Problems (bronchospasm)

This medicine should not be used in patients suffering from bronchospasm.

Medicine Containing Long-Acting Beta-Agonists

This medicine should not be used in patients taking long-acting beta-agonists such as salmeterol, arformoterol, indacaterol, and formoterol. These patients may experience increased the occurrence of adverse effects.

Anticholinergics

This medicine should not be used in patients taking anticholinergics. When Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is used with anticholinergic, it may produce an additive effect which may lead to anticholinergic side effects. Also, optic nerve damage (glaucoma), cloudiness of the lens in the eye (cataracts), and increased intraocular pressure have been reported in patients suffering from moderate to severe airflow obstruction from the lungs and using Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate with inhaled anticholinergics. These patients may have the following symptoms if they use this medicine:
  • inability to completely or partially empty the bladder
  • difficult in passing urine or painful urination
  • blurred vision
  • red eyes with colored images
  • conjunctival congestion
  • swelling of the cornea, and vision problems (visual halos)

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Fluticasone Furoate+Umeclidinium Bromide+Vilanterol Trifenatate is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate .
Chronic Obstructive Pulmonary Disease
Lung Diseases
Bronchial Disorders
Asthma

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