Allergic Reactions
After using Ofloxacin+Ornidazole for the first time, allergic reactions have been reported. Allergic reactions may proceed to
shock which is life-threatening, even after the first use. Ofloxacin should not be used in such cases. Also, start suitable therapy (e.g shock treatment).
Hospital-Acquired Diarrhea
During and after the treatment with Ofloxacin+Ornidazole if
diarrhea becomes severe, persistent or bloody, it may further lead to inflammation of the large intestine. In such cases, ofloxacin should be stopped instantly. Start suitable
antibiotic therapy (e.g. vancomycin, metronidazole, oral teicoplanin) without delay. Drugs blocking the
contraction and relaxation of muscles should not be used in this situation.
Brain Diseases
Treatment with Ofloxacin+Ornidazole should be stopped in case of convulsive
seizures. Patients with damaged nerve cells in the brain and spinal cord should be cautious while taking this medicine.
Cardiac Disorders
Patients with heart disease present by birth, using combined drugs that cause heart rhythm disorder, uncorrected electrolyte imbalance in elderly, heart-related disease are at a higher risk when using this medicine. Rare cases of heart rhythm disorder have been seen in patients taking ofloxacin. Patients with well-known risk factors for heart rhythm disorder should be cautious when using ofloxacin. Also, patients treated with Ofloxacin+Ornidazole should not expose themselves to strong sunlight and avoid UV rays (e.g. sun lamps).
Psychotic Disorders
Patients were reported with mental disorders while taking ofloxacin. This disorder progressed to a
suicide attempt and thoughts after an individual dose. The condition in which the patients develops such reactions, Ofloxacin+Ornidazole use should be discontinued and start taking proper measures. Patients with a history of severe mental disorder or mental illness should be cautious while taking Ofloxacin+Ornidazole.
Abnormality in the Functioning of Liver
Patients with an abnormality in the functioning of the liver are at an increased risk when using Ofloxacin+Ornidazole. These patients may have liver damage. Fluoroquinolones may cause sudden liver failure (fulminant
hepatitis) which may lead to liver failure including fatality. Precaution should be taken in patients with abnormal functioning of the liver. Ofloxacin+Ornidazole treatment should be stopped if this happens. Patients should contact the doctor if symptoms of liver disease such as
jaundice, severe
itching, loss of appetite, dark urine, and stomach
pain occur.
Patients Taking Vitamin-K Antagonists (Warfarin)
. These patients may experience an increase in
bleeding time or coagulation tests. Patients should be advised for the monitoring of coagulation tests such as prothrombin time and international normalized ratio when using a combination of ofloxacin with warfarin.
Weakness in Skeletal Muscles
Patients with a history of weakness of skeleton muscles are at an increased risk when using Ofloxacin+Ornidazole. Patients taking
antibiotics for the long term may cause an increase in the number of resistant micro-organisms. Regular checkup should be done for such patients. On the occurrence of secondary infections, suitable measures should be taken.
Nerve Damage in Hands and Feets
Patients taking ofloxacin are at an increased risk. Patients taking ofloxacin may cause
pain in nerves of hands, arms and feet. Ofloxacin+Ornidazole use should be stopped if the patient has symptoms of nerve damage to prevent the progress of conditions which cannot be treated.
Low Blood Sugar
Patients with high blood sugar level taking an oral
hypoglycemic drug (glibenclamide) or
insulin are at an increased risk. These patients may experience low blood sugar level. Such patients should be advised for monitoring of blood sugar levels.
Glucose-6-Phosphate-Dehydrogenase Deficiency
Patients with glucose-6-phosphate-dehydrogenase deficiency are at an increased risk when using Ofloxacin+Ornidazole. These patients may experience blood-related reactions when used with ofloxacin. Precaution must be taken in patients when using Ofloxacin+Ornidazole.
Genetic Problems
Patients with genetic problems such as galactose intolerance, lactose intolerance or glucose-galactose intolerance are at an increased risk while using Ofloxacin+Ornidazole. Ofloxacin+Ornidazole should not be used in patients with genetic problems such as galactose intolerance, lactose intolerance or glucose-galactose intolerance.