Abnormal Functioning of the Liver
Patient with the condition of the abnormal liver function or other liver diseases is at increased risk when using this medicine. The patient using Joltan Plus therapy can develop changes in the blood and electrolyte balance
that may lead to liver damage. The patient should use the drug with caution.
The patients who are pregnant or who are planning to conceive are at increased risk when using this medicine. The patient should discontinue this Joltan Plus therapy.
Patients using lithium
during thiazide therapy are at an increased risk while using this medicine. Use of diuretic
agents (Joltan Plus) reduce the clearance of lithium by the kidney which may lead to fatal conditions. The lithium should not be given during the thiazide therapy.
Fluid or Electrolyte Disturbances
The combined use of Joltan Plus with potassium
supplements, potassium-sparing diuretics
substitutes containing potassium, or other agents may increase blood potassium levels. The patient should be monitored periodically for blood electrolytes, and Joltan Plus therapy should be discontinued in the case of evident kidney damaging.
Abnormal Functioning of the Kidney
Patients with the condition of heart failure, narrowing of arteries that carry blood to the kidneys or having treatment with angiotensin converting enzymes and angiotensin II receptor blockers are at a higher risk when using this medicine. Patient taking Valsartan therapy has been associated with decreased production of urine and abnormally high levels of nitrogen in the body with abnormal functioning of the kidney and it can be fatal. But in the case of ACE inhibitors, there is an increase in creatinine
level and blood urea nitrogen. Patient should use the drug with caution and there should be periodic monitoring of potassium
and creatinine levels while taking Joltan Plus therapy.
Nearsightedness and Increased Intraocular Pressure of the Eye
Patients with the known history of sulfonamide or penicillin allergy
are at an increased risk when using this medicine. The combined use of Hydrochlorothiazide and sulfonamide can produce drug reaction which results in nearsightedness
, increased intraocular pressure of the eye, decreased visual clarity, pain
in the eye and if it is not treated loss of vision can occur. The patient should discontinue the use of hydrochlorothiazide and surgical treatment should be provided when the situation is uncontrolled.
Increased Sensitivity to Sunlight
Patient taking thiazide diuretics
have been reported with the allergic reaction of sunlight. The patient should be advised to stop the Joltan Plus treatment and if reuse is required then protect visible areas from exposure of sunlight.
Newborn Disease and Their Fatality Rate
Patients who are pregnant or who want to conceive are at the higher risk when using this medicine. Studies suggest that ACE inhibitor including Joltan Plus therapy is associated with injury in newborns such as high blood pressure, poor skull development, prevents or limits the normal excretion of urine, reversible or irreversible kidney damage and fatality. Intrauterine exposure to the use of thiazide diuretics
within the uterus cause yellowing of skin of the newborn, decrease in platelets
and other side effects. The patient should be informed of the possible risk to the fetus.
Low Blood Pressure in Salt Depleted Patients
Patient with a condition of abnormal blood pressure or in the case of a decrease in extracellular fluid volume when salt
and fluid declines are at increased risk when using this medicine. Patient receiving large doses of diuretics
may have an excessive reduction of blood pressure. This dose should be adjusted before the use of Joltan Plus and therapy should be started under the proper medical guidance.
Abnormal Liver Function
Patient with the condition of abnormal liver function or with progressive liver disease and in case of a blockage in the duct that takes bile from the liver to the gallbladder are at an increased risk when using this medicine. The patient using hydrochlorothiazide may accelerate brain damage because of liver failure and in the case of valsartan, it showed lowered clearance of valsartan. The patient should use hydrochlorothiazide with caution and care should be taken while taking valsartan.
The patients with or without the condition of allergy
or breathing disorder are at a higher risk when they are using this medicine. The patient using hydrochlorothiazide may have an allergic reaction.
The Immune System Attacking its own Cells
Worsening of the functioning of immune system has been reported with the use of hydrochlorothiazide.