Severe Low Blood Sugar Level
Patients with severe low blood sugar level are at an increased risk when using this medicine. Such patients may have an increased risk of loss of consciousness or convulsions and may result in temporary or permanent abnormality in the functioning of the brain or can be possibly fatal. Use necessary precautions while starting and increasing the dose of Mepiryl in elderly patients, patients with abnormal functioning of the kidneys and in patients who are on other anti-diabetic medicines.
Allergy to Mepiryl
Patients who are allergic to Mepiryl are at an increased risk when using this medicine. Mepiryl can cause allergic reactions including life-threatening allergic reaction, swelling of the lower layer of the skin, severe skin reaction (called, stevens-johnson syndrome
). If an allergic reaction occurs, discontinue the use of Mepiryl, and alternative treatment for low blood sugar level should be taken.
Enzyme (Glucose 6-Phosphate Dehydrogenase) Deficiency
Patients with enzyme (glucose 6-phosphate dehydrogenase) deficiency are at an increased risk when using sulfonylureas. Use of sulfonylureas can cause red blood cells deficiency in these patients. Precaution should be taken in patients with enzyme (glucose 6-phosphate dehydrogenase) deficiency and use of non-sulfonylurea should be considered.
Patients with inherited disorders such as reduced or absent activity of lactase (galactose intolerance), enzyme (Lapp lactase) deficiency or defect in glucose and galactose transport across the intestinal are at increased risk while using this medicine. The use of this medicine is avoided in patients with lactose intolerance as it contains lactose monohydrate.
Alterations in Diet in Patients Using Mepiryl
When meals are taken at the irregular interval or skipped altogether, treatment with Mepiryl may increase the risk of low blood sugar levels. This medicine cause headache
, vomiting, insomnia
, restlessness, aggressiveness, depression
, alertness and reaction time, confusion
, speech and visual disorders, speech problems, tremor
, muscular weakness, sensory disturbances, dizziness
, helplessness, loss of self-control, disturbance in mental abilities, convulsions, sleeplessness, slow heart rate, sweating, decreased or increased heartbeat, clammy skin, anxiety
, rapid heart rate, high blood pressure, palpitation
, and chest pain
. Mepiryl should be taken shortly before or during a meal.
Abnormal Functioning of the Kidney
Such patients are at an increased risk when using this medicine. Use of Mepiryl can cause low blood sugar level in these patients. Use of insulin
is indicated in patients with abnormal functioning of the kidneys.
Severe Abnormal Functioning of the Liver
Patients with severe abnormal functioning of the liver are at an increased risk when using this medicine. Use of Mepiryl can cause low blood sugar level in these patients. Regular monitoring of liver and blood parameters such as leucocytes and thrombocytes are required during treatment with Mepiryl tablets.