After using O2 for the first time, allergic reactions have been reported. Allergic reactions may proceed to shock
which is life-threatening, even after the first use. Ofloxacin should not be used in such cases. Also, start suitable therapy (e.g shock treatment).
During and after the treatment with O2 if diarrhea
becomes severe, persistent or bloody, it may further lead to inflammation of the large intestine. In such cases, ofloxacin should be stopped instantly. Start suitable antibiotic
therapy (e.g. vancomycin, metronidazole, oral teicoplanin) without delay. Drugs blocking the contraction
and relaxation of muscles should not be used in this situation.
Treatment with O2 should be stopped in case of convulsive seizures
. Patients with damaged nerve cells in the brain and spinal cord should be cautious while taking this medicine.
Patients with heart disease present by birth, using combined drugs that cause heart rhythm disorder, uncorrected electrolyte imbalance in elderly, heart-related disease are at a higher risk when using this medicine. Rare cases of heart rhythm disorder have been seen in patients taking ofloxacin. Patients with well-known risk factors for heart rhythm disorder should be cautious when using ofloxacin. Also, patients treated with O2 should not expose themselves to strong sunlight and avoid UV rays (e.g. sun lamps).
Patients were reported with mental disorders while taking ofloxacin. This disorder progressed to a suicide
attempt and thoughts after an individual dose. The condition in which the patients develops such reactions, O2 use should be discontinued and start taking proper measures. Patients with a history of severe mental disorder or mental illness should be cautious while taking O2.
Abnormality in the Functioning of Liver
Patients with an abnormality in the functioning of the liver are at an increased risk when using O2. These patients may have liver damage. Fluoroquinolones may cause sudden liver failure (fulminant hepatitis
) which may lead to liver failure including fatality. Precaution should be taken in patients with abnormal functioning of the liver. O2 treatment should be stopped if this happens. Patients should contact the doctor if symptoms of liver disease such as jaundice
, severe itching
, loss of appetite, dark urine, and stomach pain
Patients Taking Vitamin-K Antagonists (Warfarin)
. These patients may experience an increase in bleeding
time or coagulation tests. Patients should be advised for the monitoring of coagulation tests such as prothrombin time and international normalized ratio when using a combination of ofloxacin with warfarin.
Weakness in Skeletal Muscles
Patients with a history of weakness of skeleton muscles are at an increased risk when using O2. Patients taking antibiotics
for the long term may cause an increase in the number of resistant micro-organisms. Regular checkup should be done for such patients. On the occurrence of secondary infections, suitable measures should be taken.
Nerve Damage in Hands and Feets
Patients taking ofloxacin are at an increased risk. Patients taking ofloxacin may cause pain
in nerves of hands, arms and feet. O2 use should be stopped if the patient has symptoms of nerve damage to prevent the progress of conditions which cannot be treated.
Low Blood Sugar
Patients with high blood sugar level taking an oral hypoglycemic
drug (glibenclamide) or insulin
are at an increased risk. These patients may experience low blood sugar level. Such patients should be advised for monitoring of blood sugar levels.
Patients with glucose-6-phosphate-dehydrogenase deficiency are at an increased risk when using O2. These patients may experience blood-related reactions when used with ofloxacin. Precaution must be taken in patients when using O2.
Patients with genetic problems such as galactose intolerance, lactose intolerance or glucose-galactose intolerance are at an increased risk while using O2. O2 should not be used in patients with genetic problems such as galactose intolerance, lactose intolerance or glucose-galactose intolerance.