O2 Tablet

Generic Name(s): Ofloxacin, Ornidazole

Why it's used

O2 Tablet is a prescription medicine that is used to treat infections caused by bacteria requiring and not requiring oxygen for growth. These infections include diarrhea, stomach infection, disorders of the female reproductive system and pelvic infections. It also used to treat foot ulcers especially in patients with diabetes, lung infection, and patients with a weak immune system. This medicine works by killing bacteria that cause infections. Also, ornidazole blocks protozoal growth and Ofloxacin prevents bacterial DNA replication.
When not to use
O2 Tabletwill not work to treat viral infections such as common cold.
Fluoroquinolone Antibacterial
O2 belongs to the Fluoroquinolone Antibacterial class of medicines. Fluoroquinolones are medicines used for the treatment and prevention of certain types of bacterial infections. These medicines are commonly used to treat respiratory and urinary tract infections.

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How to use

Follow directions on the product label, information guide, and provided by your doctor before using O2. Eat this medicine as per your doctor's instructions.
O2 is eaten with or without food. The use of ofloxacin with food does not change the blood level of a drug but increase the time of medicine to reach in blood.

Typical Dosage

The typical adult dose of O2 is one dose of O2 twice daily.
You should continue to use this medicine as directed by the doctor even if you feel well.

Talk to Your Doctor

Tell your doctor if your condition does not improve or worsens. Talk to your doctor if diarrhea with or without stomach cramps. If you have any kidney disease, There is no dose adjustment required in case of ornidazole when given to the patient with kidney failure. But ofloxacin is known to be eliminated by the kidney, and elderly patients show decreased functioning of kidneys. So, dose adjustment is required in elderly patients with kidney failure. If you have issues with the health of your liver, Dose adjustment is required in patients with severe liver disease. The dosing interval should be doubled in these patients. Consult with your doctor before stopping the use of O2 Tablet.

Use in Children

The safety and effectiveness of using this medicine in children has not been established.

Avoid Alcohol

Avoid drinking alcohol with O2.

Storage

Store O2 Tablet in a cool dry place, and away from light. Keep this medicine away from children and pets.
Medicines may be given for uses other than those listed in the medicine guide. Do not use O2 Tablet for symptoms for which it was not prescribed. Do not giveO2 Tabletto others who may have similar symptoms as you. Self-medication can cause harm.

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How to take O2

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of O2 depends on the following factors:
  • the health of the patient's liver
  • the health of the patient's kidneys

O2 Dosage

Dosage for aerobic-anaerobic infections

Adult
  • Recommended: one tablet twice daily

Forms

Film-coated tablet
Strength: 200/500 mg

Overdose

What to do if you overdose on O2?
In the case of ofloxacin overdose, adsorbents and sodium sulfate should be possibly used during the first 30 minutes. Antacids are used to protect the acidity and damage to the layer of the stomach. Ofloxacin elimination from the body should be done by inducing vomiting and forced excessive urine production. Due to the possibility of prolongation in time of ventricular activity, monitoring of heart rhythm is required. In the case of ornidazole overdose, elimination of ornidazole from the body should be done by purification of blood and stomach cleaning. For convulsions, treatment is symptomatic and diazepam should be given intravenously as there is no specific antidote is available.
Symptoms of an overdose of O2
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on O2 Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using O2

Before you use O2, tell your doctor of your medical and health history including the following:
  • allergic reactions
  • anti-arrhythmic agents Class IA and Class III
  • heart attack
  • inflammation of tendons
  • irregular heartbeat
  • low level of potassium in the blood
  • mental disorders
  • muscle weakness
  • seizures
Mental disorders were shown to progress into suicidal thoughts or suicide attempt, even after the single dose. Allergic reactions lead to life-threatening shock which can also take place after using the first dose. The heart attack may lead to heart rhythm disorder.
Before you use O2 Tablet, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic any of the following substances: quinolones, or other nitroimidazole derivatives.
The use of this medicine may change the creatinine level. It may cause an increase in the creatinine level.
The use of this medicine may change alanine transaminase. It may cause an elevated level of alanine transaminase.
The use ofO2 Tabletmay change aspartate transaminase. It may cause an elevated level of aspartate transaminase.
The use of this medicine may change alkaline phosphatase. It may cause elevated levels of alkaline phosphatase.
The use ofO2 Tabletmay change the erythrocyte sedimentation rate. It may cause an increase in the level of erythrocyte sedimentation rate.

Seizures

O2 Tablet can make you feel sleepy. Be careful when using any machinery, driving a vehicle, or doing any other activity that needs you to be fully alert. The consumption of alcohol withO2 Tabletcan worsen the sleepiness.O2 Tabletmay cause rarely seizures in some people. If you perform any activities where a loss of consciousness may cause harm to you (or others), you should discuss with your doctor.

Use in Pregnancy

The use of O2 is known to be not safe for use in pregnant women. If you are planning to become pregnant or are currently pregnant, you should discuss with your doctor the potential impact of this medicine on the baby before you start to using it. The safety and efficacy of both ofloxacin and ornidazole have not been established in pregnant women. But ornidazole is recommended during pregnancy if its possible benefit to the mother explains the possible risk to the fetus.

Use while Breastfeeding

The use ofO2 Tabletis not safe for use in women who are breastfeeding. If you are breastfeeding a baby, discuss with your doctor if you should either discontinue breastfeeding or stop using this medicine while breastfeeding. The safety and efficacy of both ofloxacin and ornidazole have not been established in breastfeeding. But ornidazole is recommended during breastfeeding if its possible benefit to the mother explains the possible risk to the baby.

Alcohol

Avoid consuming alcohol together with O2. Drinking alcohol may cause sleepiness, lack of coordination, dizziness, blurred vision, and loss of balance.

Increased Risks

This medicine may cause bleeding in the stomach. Regular use of tobacco or alcohol while using this medicine can increase your risk. Discuss with your doctor if you smoke and drink alcohol regularly. This medicine may increase your sensitivity to sunlight. If this happens, use a sunscreen and cover your skin when you are outdoors. Limit your time in the sun.

Side-effects in Children

O2 may cause an increased risk of side-effects in children.

What precautions should be taken during Pregnancy and Nursing, and administering O2 to Children or the Older Adults?

Pregnant Women

Contraindicated or Not Recommended
Warning: The safety and efficacy of both ofloxacin and ornidazole have not been confirmed during pregnancy. But ornidazole is recommended to pregnant women if its possible benefit to the mother justifies the possible risk to the fetus.

Breastfeeding

Contraindicated or Not Recommended
Warning: The safety and efficacy of both ofloxacin and ornidazole have not been confirmed in breastfeeding. But ornidazole is recommended during breastfeeding if its possible benefit to the mother describes the possible risk to the baby.

Younger Adults Population

Contraindication
Warning: O2 should not be used in children. The safety and efficacy of ofloxacin have not been established in children below 18 years.

Older Adults Population

Precaution
Warning: The risk of severe tendon disorders, including rupturing of the tendon, can occur in elderly patients after using ofloxacin.

O2 Side-effects

The following side-effects may commonly occur when using O2 Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Rarely, the use ofO2 Tabletmay cause the following side-effects:
  • abnormal sensation in the body
  • altered sense of taste
  • burning
  • chest pain
  • chills
  • cough
  • decreased appetite
  • decreased hearing acuity
  • difficult urination
  • disturbances of taste and smell
  • dry mouth
  • excess of proteins in the urine
  • excessive mucous secretion from the nose
  • excretion of glucose into the urine
  • extremity pain
  • fainting
  • fatigue
  • feeling of discomfort
  • gas formation
  • heartburn
  • hiccough
  • hives
  • indigestion
  • insomnia
  • intense excitement
  • irritation
  • joint pain
  • lack of muscle coordination
  • lightheadedness
  • muscle pain
  • nervousness
  • nosebleed
  • pain and rash of the female genitalia
  • painful periods
  • palpitations
  • phobia
  • photophobia
  • rash
  • rash
  • restlessness
  • ringing in the ears
  • severe itching
  • small red or purple spot
  • stomach and intestinal distress
  • stomach cramps
  • stomach pain
  • swelling
  • thirst
  • tremor
  • trunk pain
  • urine containing white blood cells
  • vaginal discharge
  • vertigo
  • weakness
  • weight loss
The following severe side-effects may also occur when using O2 Tablet:
  • Nervous system disorders
    Symptoms: seizures, anxiety, cognitive change, depression, dream abnormality, hallucinations, abnormal sensation in the body, confusion, nightmares, suicidal thoughts, psychotic reactions, fearful feelings, restlessness, aggressiveness, manic reaction, emotional lability, nerve damage in hands and feet, incoordination, worsening of muscle weakness, language disorder, lightheadedness excessive sleepiness
    In the case of seizures and psychotic reactions, treatment with O2 should be discontinued. Precaution should be taken in patients with brain and spinal cord disorder (multiple sclerosis) and psychiatric disease.
  • Musculoskeletal system disorders
    Symptoms: inflammation of tendons muscle breakdown
  • Genital system disorders
    Symptoms: vaginal yeast infection, heavy bleeding at menstruation abnormal bleeding in between the periods
  • Gastrointestinal system disorders (possibly fatal)
    Symptoms: liver dysfunction, liver failure, jaundice, hepatitis, hole in the wall of the intestine, inflammation of the large intestine stomach and intestinal bleeding
  • Heart-related disorders
    Symptoms: cardiac arrest, high blood pressure, low blood pressure, vasodilation, a blood clot in the brain, swelling in the hands and feet, increased heart rate heart rhythm disorder
  • Respiratory system disorders
    Symptoms: respiratory arrest, spasm of bronchial smooth muscle, inflammation of the alveoli musical breathing sound
  • Allergic reactions (life-threatening shock)
    Symptoms: area of swelling of the lower layer of the skin, sweating, inflammation of blood vessels, rash of purple spots on the skin, allergic reaction to a foreign substance, severe skin reaction, severe allergic reaction, skin inflammation, excessive pigmentation of the skin, inflammation of the conjunctiva, sensitivity to light, photoirritation blisters
    In such cases, the patient should discontinue ofloxacin and suitable therapy should be started.
  • Special Senses
    Symptoms: double vision, blurred vision disturbance in hearing
  • Liver disorders
    Symptoms: elevated alkaline phosphatase level, elevated aspartate aminotransferase level increased alanine aminotransferase level
  • Urinary system disorders
    Symptoms: kidney stones, kidney failure, swelling in between the kidney tubules, blood in urine, the presence of albumin in the urine, the presence of yeast in the urine (candiduria) incomplete clearance of bladder
Your doctor has prescribed this O2 because they have judged that the benefits outweigh the risks posed by side-effects. Many people using this medicine do not have serious side-effects. This is not a complete list of possible side-effects for O2.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of O2 by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:

Side-effects in Older Adults

Following are the side-effects of this medicine in elderly patients:
  • decreased renal function

Mild Allergic Reactions

Following are the symptoms of mild allergic reactions to this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
  • allergic reaction to a foreign substance
  • area of swelling of the lower layer of the skin
  • blisters
  • excessive pigmentation of the skin
  • inflammation of blood vessels
  • inflammation of the conjunctiva
  • photoirritation
  • rash of purple spots on the skin
  • sensitivity to light
  • severe allergic reaction
  • severe skin reaction
  • skin inflammation
  • sweating
In such cases, the patient should discontinue ofloxacin and suitable therapy should be started.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Allergic Reactions

After using O2 for the first time, allergic reactions have been reported. Allergic reactions may proceed to shock which is life-threatening, even after the first use. Ofloxacin should not be used in such cases. Also, start suitable therapy (e.g shock treatment).

Hospital-Acquired Diarrhea

During and after the treatment with O2 if diarrhea becomes severe, persistent or bloody, it may further lead to inflammation of the large intestine. In such cases, ofloxacin should be stopped instantly. Start suitable antibiotic therapy (e.g. vancomycin, metronidazole, oral teicoplanin) without delay. Drugs blocking the contraction and relaxation of muscles should not be used in this situation.

Brain Diseases

Treatment with O2 should be stopped in case of convulsive seizures. Patients with damaged nerve cells in the brain and spinal cord should be cautious while taking this medicine.

Cardiac Disorders

Patients with heart disease present by birth, using combined drugs that cause heart rhythm disorder, uncorrected electrolyte imbalance in elderly, heart-related disease are at a higher risk when using this medicine. Rare cases of heart rhythm disorder have been seen in patients taking ofloxacin. Patients with well-known risk factors for heart rhythm disorder should be cautious when using ofloxacin. Also, patients treated with O2 should not expose themselves to strong sunlight and avoid UV rays (e.g. sun lamps).

Psychotic Disorders

Patients were reported with mental disorders while taking ofloxacin. This disorder progressed to a suicide attempt and thoughts after an individual dose. The condition in which the patients develops such reactions, O2 use should be discontinued and start taking proper measures. Patients with a history of severe mental disorder or mental illness should be cautious while taking O2.

Abnormality in the Functioning of Liver

Patients with an abnormality in the functioning of the liver are at an increased risk when using O2. These patients may have liver damage. Fluoroquinolones may cause sudden liver failure (fulminant hepatitis) which may lead to liver failure including fatality. Precaution should be taken in patients with abnormal functioning of the liver. O2 treatment should be stopped if this happens. Patients should contact the doctor if symptoms of liver disease such as jaundice, severe itching, loss of appetite, dark urine, and stomach pain occur.

Patients Taking Vitamin-K Antagonists (Warfarin)

. These patients may experience an increase in bleeding time or coagulation tests. Patients should be advised for the monitoring of coagulation tests such as prothrombin time and international normalized ratio when using a combination of ofloxacin with warfarin.

Weakness in Skeletal Muscles

Patients with a history of weakness of skeleton muscles are at an increased risk when using O2. Patients taking antibiotics for the long term may cause an increase in the number of resistant micro-organisms. Regular checkup should be done for such patients. On the occurrence of secondary infections, suitable measures should be taken.

Nerve Damage in Hands and Feets

Patients taking ofloxacin are at an increased risk. Patients taking ofloxacin may cause pain in nerves of hands, arms and feet. O2 use should be stopped if the patient has symptoms of nerve damage to prevent the progress of conditions which cannot be treated.

Low Blood Sugar

Patients with high blood sugar level taking an oral hypoglycemic drug (glibenclamide) or insulin are at an increased risk. These patients may experience low blood sugar level. Such patients should be advised for monitoring of blood sugar levels.

Glucose-6-Phosphate-Dehydrogenase Deficiency

Patients with glucose-6-phosphate-dehydrogenase deficiency are at an increased risk when using O2. These patients may experience blood-related reactions when used with ofloxacin. Precaution must be taken in patients when using O2.

Genetic Problems

Patients with genetic problems such as galactose intolerance, lactose intolerance or glucose-galactose intolerance are at an increased risk while using O2. O2 should not be used in patients with genetic problems such as galactose intolerance, lactose intolerance or glucose-galactose intolerance.

Interactions with O2

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of O2 Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Non-Steroidal Anti-Inflammatory Drugs

O2 Tablet interacts with non-steroidal anti-inflammatory drugs, which are used to reduce pain, decrease fever, prevent blood clots and, in higher doses, decrease inflammation. The combined use of non-steroidal anti-inflammatory drugs with ofloxacin may increase the chance of stimulation of the brain and seizures within the whole body.

Aminosteroid Neuromuscular-Blocker

There may be an interaction of O2 with aminosteroid neuromuscular-blocker (vecuronium bromide), which is used to relax skeletal muscle during surgery. Ornidazole increases the muscle-relaxant activity of vecuronium bromide.

Histamine H2 Receptor Antagonists

O2 Tablet may interact with histamine H2 receptor antagonists (cimetidine), which are used to block stomach acid production. When cimetidine is used with ofloxacin, it interferes with the elimination of ofloxacin. Therefore, it results in an increase in time taken by ofloxacin to get eliminated by 50% from the blood.

Xanthines

Your doctor's guidelines may need to be followed while taking this medicine along with xanthines (theophylline), which are used to treat lung diseases. The combined use of ofloxacin with theophylline prolongs the time taken by theophylline to get eliminated by 50% from the blood, increase the blood level and side effects associated with theophylline. Dose adjustment of theophylline should be done while using with ofloxacin and theophylline blood level should be monitored closely in patients.

Uricosuric Drugs

Special instructions need to be followed while taking this medicine along with uricosuric drugs (probenecid), which are used to treat severe pain, redness, and tenderness in joints and excess of uric acid. The combined use of probenecid with ofloxacin may show an effect on the transfer of materials from blood vessels to the kidney tubules.

Laboratory Tests

Your doctor's guidelines may need to be followed while taking this medicine along with effects on laboratory tests. Use of ofloxacin produces false-positive urine drug test by using commercially available immunoassay kits.

Sucralfate, Metal Cations, Antacids, Multivitamins

Special instructions need to be followed while taking this medicine along with antacids used to relieve heartburn, metal cations which are used to maintain optimal health, sucralfate used to treat stomach ulcer, and multivitamins are used to treat vitamin deficiencies. Ofloxacin combined use with alkaline earth and transition metal cations results in the formation of ions. The combined use of ofloxacin with antacids containing calcium, magnesium, or aluminum, sucralfate, with iron cations, or multivitamins containing zinc, or didanosine may interfere in ofloxacin absorption which results in lowering of its systemic levels than the desired level. These drugs should not be used within the two hour period before or after O2 use.

Drugs Metabolized by Cytochrome P450 Enzymes

O2 Tablet interacts with drugs metabolized by cytochrome P450 enzymes (cyclosporine, theophylline/methylxanthines and warfarin). Ofloxacin blocks the cytochrome P450 enzyme activity, so combined use of ofloxacin with drugs metabolized by cytochrome P450 enzyme may prolong time taken by these drugs to get eliminated by 50% from the blood.

Antidiabetic Agents

There may be an interaction of O2 with antidiabetic agents (insulin and glyburide/glibenclamide) which are used to lower the sugar level in the blood. The combined use of antidiabetic agent and ofloxacin shows the interference of blood sugar level including an increase and decrease in the blood sugar level. Blood sugar level should be carefully monitored in the patient.

Oral Anticoagulants

O2 Tablet may interact with oral anticoagulants (warfarin), which is used to prevent the clotting of blood. When ofloxacin is used in combination with warfarin, it increases the effect of warfarin or its derivatives. It is recommended to monitor the clotting time of blood or other suitable tests for blood clotting in patients.

Coumarin-Type Oral Anticoagulants

O2 Tablet may interact with coumarin-type oral anticoagulants which are used to prevent the clotting of blood. Ornidazole increases the effect of coumarin anticoagulants. The dose of anticoagulant should be adjusted when given with ornidazole.

Interactions of O2 by Severity

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should O2 be not used?

Known Allergic Reactions

O2 should not be used in patients having the previous history of allergic reactions to O2 or any of quinolone or nitroimidazole group of antimicrobial agents. These patients may have the following symptoms if they use this medicine:
  • fever
  • rash
  • inflammation of the blood vessels
  • joint pain
  • muscle pain
  • an allergic reaction to foreign particles
  • inflammation of lungs
  • forming kidney diseases
  • acute kidney failure
  • liver infection
  • yellowing of the skin or whites of the eyes
  • low levels of thrombocytes
  • low level of red blood cells
  • low level of white blood cells
  • blood disease

Inflammation of a Tendon

O2 should not be used in patients having the previous history of inflamed tendons. Risk of inflammation can occur during or after the completion of treatment or maybe after several months of the treatment. Therefore, the patient should be informed about these side effects. Also, if it occurs the treatment should be stopped after consulting the doctor. The risk of severe tendon disorders, including rupturing of the tendon, can occur in patients using ofloxacin. This risk will be higher in elderly patients and patients receiving combined corticosteroid therapy. These patients may have the following symptoms if they use this medicine:
  • inflammation of achilles tendon
  • inflammation of hand, shoulder, and tendon sites

Seizures

O2 should not be used in patients having a previous history of seizures or having low susceptibility to seizures.

Defects in Glucose-6-Phosphate Dehydrogenase Activity

O2 should not be used in patients with possible defects in glucose-6-phosphate dehydrogenase activity which may lead to serious complications due to blood transfusion.

Children

O2 should not be used in children.

Pregnancy and Breastfeeding

O2 should not be given during pregnancy and breastfeeding.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired O2 is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for O2 Tablet .
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