Pas Tablet

Generic Name(s): Nimesulide

Why it's used

Pas Tablet is used to treat acute (short-term) pain, painful osteoarthritis (swelling in the joints) and pain related with menstrual periods (primary dysmenorrhoea). This medicine works by blocking the enzyme activity (cyclooxygenase 1 and cyclooxygenase 2) which generates pain signals in the body. This medicine helps by exerting pain killing actions.
Nonsteroidal Anti-inflammatory Drugs
Pas is a prescription medicine that belongs to a class of medicines called Nonsteroidal Anti-inflammatory Drugs. Nonsteroidal anti-inflammatory drugs, also called as NSAIDs, help reduce fever, decrease pain, and prevent clotting of blood. NSAIDs also reduce inflammation in the body when used in higher doses.

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How to use

Follow directions on the product label, information guide, and provided by your doctor before using Pas. Consume this medicine as per your doctor's instructions.
Pas is consumed after food.

Typical Dosage

The typical adult dose of Pas is 100 mg twice a day after meals. The typical dose for children is 100 mg twice a day. The maximum dose for adults of Pas is 100 mg twice daily per day. This medicine is commonly used for a period of 15 days for acute pain, 15 days for painful swelling in the joints (painful osteoarthritis), and 15 days for pain related with menstrual periods (primary dysmenorrhoea). There are no known habit-forming tendencies with this medicine.
This medicine should be used on an as-needed basis.

Talk to Your Doctor

Tell your doctor if you develop new or worsening symptoms. Talk to your doctor if the loss of appetite, nausea, vomiting, stomach pain, persistent tiredness, dark urine, fever, flu-like symptoms, feeling achy, feeling unwell, and chills. If you have issues with the health of your liver, The use of Pas 100mg Tablets/granules is not recommended in patients with liver dysfunction.
To see the impact of Pas Tablet on the body, your doctor may recommend a lower initial dose. Please follow your doctor's instructions carefully. Older patients may see an increase in the risk of side-effects. Hence, a lower dose may be recommended.

Use in Children

The safety and effectiveness of using this medicine in children has not been established. The use of Pas is not intended for children less than 12 years. However, patients of 12-18 years can take Pas tablets/granules, and there is no need for dose adjustment in such patients.

Avoid Alcohol

Avoid drinking alcohol with Pas.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Pas Tablet for symptoms for which it was not prescribed. Do not give Pas Tablet to others who may have similar symptoms as you. Self-medication can cause harm.

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How to take Pas

Your dose and how often you take Pas will depend on the following factors:
  • patient's health
  • the health of the patient's kidneys

Pas Dosage

Dosage for acute pain and symptoms of osteoarthritis

Adult
  • Recommended: 100 mg twice daily after meals
Children (12-18 years)
  • Recommended: 100 mg twice daily after meals

Minimum Age

12 years

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 100 mg
Granules
Strength: 100 mg

Precautions while using Pas

Before you use Pas, tell your doctor of your medical and health history including the following:
  • alcohol addiction
  • allergic to Pas
  • cerebrovascular bleeding
  • drug abuse
  • heart failure
  • increased liver enzymes
  • kidney disorders
  • liver diseases
  • long-term inflammatory bowel disease causing inflammation in the digestive tract (ulcerative colitis or Crohn’s disease)
  • severe blood clotting disorders
  • stomach and intestinal bleeding
  • stomach or intestinal ulcers
  • stroke
Before you use Pas Tablet, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic any of the following substances: acetylsalicylic acid, or other non-steroidal anti-inflammatory drugs.

Use in Pregnancy

The use of Pas is known to be not safe for use in pregnant women. If you are planning to become pregnant or are currently pregnant, you should discuss with your doctor the potential impact of this medicine on the baby before you start to using it. The use of Pas should not be done during the last 3 months of pregnancy. Pas belongs to the NSAID class of medicines. NSAIDs should not be taken after 29 weeks of pregnancy as these medicines may cause serious harm to the unborn baby.

Use while Breastfeeding

The use of Pas Tablet is not safe for use in women who are breastfeeding. If you are breastfeeding a baby, discuss with your doctor if you should either discontinue breastfeeding or stop using this medicine while breastfeeding. The use of Pas is not recommended for women who are breastfeeding their infants.

Use while Conceiving

Consult with your doctor on the use of Pas, if you are trying to conceive. Patients who are planning to conceive should inform their doctor since the use of Pas may decrease fertility.

Alcohol

Avoid consuming alcohol together with Pas.

Increased Risks

This medicine may cause bleeding in the stomach. Regular use of tobacco or alcohol while using this medicine can increase your risk. Discuss with your doctor if you smoke and drink alcohol regularly.

Side-effects in Older Patients

Pas Tablet may cause increased incidence of side-effects in older patients. Elderly patients may see an increased risk of stomach and intestinal bleeding, liver damage, abnormal functioning of the kidneys, abnormalities of the heart, and ruptured bowel.

What precautions should be taken during Pregnancy and Nursing, and administering Pas to Children or the Older Adults?

Pregnant Women

Contraindication
Warning: The use of Pas should not be done during the last 3 months of pregnancy.

Breastfeeding

Contraindication
Warning: The use of Pas is not recommended for women who are breastfeeding their infants.

Younger Adults Population

Precaution
Warning: The use of Pas in children below the age of 12 years is not recommended.

Older Adults Population

Precaution
Warning: Elderly patients are especially sensitive to the side effects of NSAIDs. Therefore, proper clinical monitoring is desirable in such patients.

Pas Side-effects

The following side-effects may commonly occur in older patients on the use of Pas Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:
  • abnormal functioning of the kidneys
  • abnormalities of the heart
  • liver damage
  • ruptured bowel
  • stomach and intestinal bleeding
The following severe side-effects may also occur when using Pas Tablet:
  • Liver disorders
    Symptoms: liver damage
Your doctor has prescribed Pas Tablet because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Pas Tablet.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Pas by Severity and Frequency

Severe Side-effects

Following are the severe side-effects of this medicine:
  • liver damage

Side-effects in Older Adults

Following are the side-effects of this medicine in elderly patients:
  • abnormal functioning of the kidneys
  • gastrointestinal hemorrhage
  • gastrointestinal perforation
  • heart abnormalities
  • impaired liver function
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Damaged Female Fertility

The use of 100mg tablets or granules of Pas may damage the fertility condition of women. Pas is not advised in women trying to conceive. Women who are undergoing research of infertility, Pas 100mg granules/ tablets should be withdrawn.

Bleeding Disorders

Pas can interfere with platelet function. The patients who have the sensitivity to bleed (bleeding diathesis) should use Pas with caution.

Kidney or Heart Damage

Elderly patients are particularly more susceptible to the side effects of NSAIDs, including stomach and intestinal bleeding and perforation, damaged kidney, heart and liver function. The use of Pas 100mg tablets or granules may result in a decline of the functioning of kidneys. Caution is needed in patients with kidney or heart damage. In the case of decline, the treatment should be discontinued. Proper clinical monitoring should be advised.

History of Stomach and Intestinal Events

Patients with history of stomach and intestinal disorders are at an increased risk. Such patients may develop an increased risk of stomach and intestinal bleeding and ulceration in the stomach. Take necessary precautions while using Pas in patients with stomach and intestinal disorders. Discontinue the use of Pas in patients who are developing the severe condition of the stomach and intestinal bleeding.

Use of Other Analgesics

Patients are advised to avoid the use of other analgesics while undergoing treatment with Pas.

Liver Damage

Patients with severe injuries of liver and abnormal liver function tests are at an increased risk. These patients may experience symptoms such as eating disorder, nausea, vomiting, stomach pain, fatigue, and dark colored urine. Rare chances of liver damage have been reported with the use of Pas. Discontinue the use of Pas in patients with severe injuries of liver and abnormal liver function tests.

Interactions with Pas

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Pas Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Cyclosporin

Your doctor's guidelines may need to be followed while taking this medicine along with cyclosporin, which is used as an immunosuppressant. The doctor or pharmacist should be informed that the patient is taking cyclosporins before starting treatment with Pas.

Lithium

Pas Tablet interacts with lithium, which is used for the treatment of mood disorders. The doctor or pharmacist should be informed that the patient is taking lithium before starting treatment with Pas.

Diuretics

There may be an interaction of Pas with diuretics, which are used to prevent some heart problems, high blood pressure, and some kidney problems. The doctor or pharmacist should be informed that the patient is taking diuretics before starting treatment with Pas.

Anticoagulants

Pas Tablet may interact with anticoagulants such as aspirin and other salicylates, which are used to prevent blood clotting. The doctor or pharmacist should be informed that the patient is taking anticoagulants before starting treatment with Pas.

Methotrexate

Special instructions need to be followed while taking this medicine along with methotrexate, which is used to treat cancer and joint pain. The doctor or pharmacist should be informed that the patient is taking methotrexate before starting treatment with Pas.

Interactions of Pas by Severity

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Pas be not used?

Use in Children and Pregnant Women

Use of Pas is not recommended in children under 12 years and in the third trimester of pregnancy and the women who are breastfeeding their infants.

Abnormal Functioning of the Kidneys

Use of 100 mg Tablets/granules of Pas should not be used in case of severe kidney damage (creatinine clearance < 30ml/min).

Allergic to Pas

Use of Pas is not recommended in patients with known allergic symptoms such as contraction of the muscles of lungs, irritation, and swelling of the mucous membrane in the nose and hives. Also, it is not used in patients allergic to Pas excipients.

Abnormal Functioning of the Liver

100 mg Tablets/granules of Pas should not be used in patients with liver abnormalities.

Stomach and Intestinal Disorders

Avoid the use of Pas in patients with stomach and intestinal ulcers, episodes of bleeding in the stomach, intestine, and brain.

Severe Abnormal Bleeding Disorders

Such patients should strictly avoid the use of Pas.

Heart Failure

Patients who are suffering from the worsening of the heart condition (heart failure) should not use Pas.

Alcoholism and Drug Addiction

Patients who are alcoholic or who have drug addiction should not use Pas.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Pas is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Pas Tablet .
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