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Why it's used

Tegretol La Tablet is used to treat a condition characterized by episodes of depression and abnormally elevated behaviour (acute manic or mixed episodes associated with bipolar I disorder), long-term pain affecting the trigeminal nerve in the face, and a disorder in which nerve cell activity in the brain is disturbed, causing different types of seizures such as partial seizures, generalized tonic-clonic seizures, and mixed seizure patterns (epilepsy). It is a prescription medicine. This medicine works by altering the transmission of certain chemicals in the brain and producing certain changes in the ion channels such as sodium and calcium.
When not to use
Tegretol La Tablet will not work to treat a type of seizure involving brief or sudden lapses in attention (absence seizures) and shock-like jerks of a muscle (myoclonic seizures).
Neuroleptics
Tegretol La belongs to a class of medicines called Neuroleptics. Neuroleptics can reduce or relieve symptoms of psychosis, such as false beliefs and seeing or hearing something that is not there (hallucinations). It is also used to treat people with schizophrenia, psychosis that occurs in bipolar disorder, depression and Alzheimer’s disease. Other uses of neuroleptics include reducing anxiety and decreasing tics in Tourette syndrome.

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How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Tegretol La Tablet. If you have any questions related to this medicine, ask your doctor or pharmacist. Eat this medicine as recommended by your doctor.
Tegretol La Tablet is eaten with or without food. This medicine should be swallow whole with a teaspoon of applesauce and do not chew or crush the Tegretol La.

Typical Dosage

The typical dose of Tegretol La is 200 mg once daily (not more than 1200 mg in one day). The usual dose for children is 200 mg twice daily (not more than 600 mg twice in one day). The maximum adult dose of Tegretol La is 1600 mg in a day.
This medicine should be used on an as-needed basis.
To decrease the possibility of side-effects, you might be recommended to use the extended-release form of this medicine by your doctor. The extended-release medicine helps in maintaining a steady level of the medicine in your body for a longer period of time. Do not crush or chew the medicine, unless indicated on the package or by your doctor.
If you are using the chewable tablet form of this medicine, make sure you chew the medicine before you swallow it.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.

Talk to Your Doctor

Talk to your doctor if you develop new or worsening symptoms. Tell your doctor if skin rash, fever, swollen glands, swelling of the lips or tongue, yellowing of the skin or eyes, unusual bruising or bleeding, weakness, severe muscle pain, and frequent infections. If you have issues with the health of your liver, a low dose will usually be given to lessen the risk of liver damage. You should consult with your doctor before stopping the use of Tegretol La.
Your doctor may recommend a lower initial dose of this medicine to see the impact of this medicine on the body. Please follow your doctor's directions. Older patients may see an increase in the incidence of side-effects with this medicine. As a result, a lower dose may be recommended for older patients.
You may need to gradually decrease the dose of this medicine before stopping.

Use in Children

If you are giving Tegretol La Tablet to a child, be sure to use a product that is meant for children. Before giving this medicine to a child, use the child's weight or age to find the right dose from the product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.

Avoid Alcohol

Avoid the consumption of alcohol with Tegretol La.

Lab Tests

Your doctor may request that specific lab tests be performed before you start using Tegretol La Tablet. You may need to have Complete Blood Count test. The patient in the therapy shows low or decreased white blood cell or platelet counts, so the complete blood count is required including platelets and possibly reticulocytes and iron levels in the blood. Your doctor may request Eye exam test. An eye examination is needed before this medicine use, as Tegretol La has been shown to cause eye changes. You may need to undergo Liver Panel test. A liver function test is needed especially in patients with a history of liver disease before taking this medicine because liver damage may occur.

Storage

You should store Tegretol La Tablet 15–30° C (59–86° F), away from moisture, and away from light. Store the medicine away from the reach of children and pets.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Tegretol La Tablet for conditions for which it was not prescribed. Do not give Tegretol La Tablet to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

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How to take Tegretol La

Your dose may depend on several personal factors. You should consult with your doctor to find out the dose that is best for you. The dose of Tegretol La depends on the following factors:
  • patient's age
  • patient's weight
  • patient's health
  • the health of the patient's kidneys

Tegretol La Dosage

Dosage for manic/mixed episodes with bipolar-I disorder

Adult
  • Initial: 200 mg twice daily, later increase the dose by 200 mg per day to gain optimal clinical response.
  • Maximum: 1600 mg per day

Dosage for long-term pain affecting a face's nerve

Adult
  • Recommended: 400 mg to 800 mg per day
  • Initial: 200 mg once daily, this dose may increase up to 200 mg/day by additions of 100 mg every 12 hours only as required to gain an effective and tolerated dose
  • Maximum: 1200 mg in a day

Dosage for epilepsy

Adult
  • Initial: 200 mg twice daily, this dose may increase weekly up to 200 mg/day taken in an equally divided, twice daily dose, to gain an optimal response
  • Maximum: 800 mg twice daily
Children (children 15 to 18 years old)
  • Initial: 200 mg twice daily, this dose may increase weekly up to 200 mg/day taken in an equally divided, twice daily dose, to gain an optimal response
  • Maximum: 600 mg twice daily
Children (children 12 to 15 years old)
  • Initial: 200 mg twice daily, this dose may increase weekly up to 200 mg/day taken in an equally divided, twice daily dose, to gain an optimal response
  • Maximum: 500 mg twice daily
Children (children under 12 years)
  • Recommended: below 35 mg/kg (15.9 mg/lb) in a day

Minimum Age

5 years

Maximum Age

100 years

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 100 mg, 200 mg, 300 mg, 400 mg
Tablet, extended release
Strength: 100 mg, 200 mg, 400 mg
Tablet chewable
Strength: 100 mg and 200 mg
Capsule, extended release
Strength: 100 mg, 200 mg, 300 mg
Suspension
Strength: 100mg, 100 mg/5ml, 200 mg/10mL
Injection, powder, for a solution
Strength: 10 mg/ml

Missed Dose

If you forget to take a dose, take one as early as you remember. If it is almost time for your next dose, though, just take the next dose and neglect about the one you missed.

Overdose

What to do if you overdose on Tegretol La?
The patient should be carefully examined and given symptomatic and supportive treatment. Proper medical supervision should be provided and ensure a sufficient airway, oxygenation, and ventilation also monitor heart rhythm and vital signs like pulse rate, temperature, respiration rate, and blood pressure.
Symptoms of an overdose of Tegretol La
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
  • abnormal heartbeat
  • below normal or absent reflexes
  • decrease in white blood cell count
  • degenerative disease of the nervous system
  • dilation of the pupil
  • dizziness
  • drowsiness
  • excess of sugar in urine (glycosuria)
  • excretion of large amounts of acetone in the urine (acetonuria)
  • failure of the kidneys to produce urine
  • inability to completely empty the bladder
  • inability to perform rapidly alternating movements (adiadochokinesia)
  • increase in the number of white blood cells
  • increased heartbeat
  • involuntary eye movement
  • irresistible urge to move (motor restlessness)
  • lack of coordination of movement (dysmetria)
  • low blood pressure
  • movement disease (ballism)
  • muscle twitching
  • nausea
  • overactive or over-responsive reflexes (hyperreflexia)
  • reduced urination
  • seizures especially in children
  • shock
  • slow, ineffective and irregular breathing
  • slow, involuntary movements of the fingers, hands, toes, and feet
  • spasm of the muscles (opisthotonos)
  • state of consciousness in severity to deep coma
  • tremor
  • unintentional and purposeless motions and restlessness (psychomotor disturbances)
  • vomiting
If you think you have overdosed on Tegretol La Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Tegretol La

Before you use Tegretol La, tell your doctor of your medical and health history including the following:
  • blood-related problems
  • bone marrow depression
  • enzyme deficiency occurs in the liver (hepatic porphyria)
  • heart disease
  • increased fluid pressure in the eye (increased intraocular pressure)
  • kidney damage
  • liver disease
  • mental health disorder (depression)
  • mood problems
  • suicidal thoughts
Cyclic evaluations of liver function in patients with a history of liver disease should be examined during Tegretol La therapy because liver damage may occur. Acute attacks have been observed in patients with a history of enzyme deficiency occurs in the liver (hepatic porphyria) with using Tegretol La and also in patients with a history of increased fluid pressure in the eye (increased intraocular pressure), examine intraocular pressure before starting the therapy and regularly during treatment.
Before you use Tegretol La Tablet, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
The use of this medicine may change white blood cell count. Use of Tegretol La can lead to increased or decreased the level of white blood cell count.
The use of Tegretol La Tablet may change platelet count. Use of Tegretol La may increase or decrease the number of the platelet count.
The use of this medicine may change thyroid function ( (T3, T4). Use of Tegretol La may decrease the levels of thyroid hormone.
The use of this medicine may change sodium level. Use of Tegretol La may lower sodium level in the blood.

Alcohol

Avoid the consumption of alcohol with Tegretol La Tablet. Drinking alcohol may cause sleepiness, and dizziness.

Use in Pregnancy

Consult with your doctor on the use of Tegretol La Tablet during pregnancy. Tegretol La may increase the risk of developing possible harm to the newborn including spine and spinal cord don't form properly (spina bifida). Talk to your doctor immediately if you become pregnant while taking Tegretol La.

Use while Breastfeeding

Consult with your doctor on the use of Tegretol La during breastfeeding. A patient should take caution when using Tegretol La during breastfeeding as this medicine passes into breast milk and may lead to newborn vomiting (neonatal vomiting), diarrhea, decreased feeding, increased seizures, and slow and ineffective breathing.

Impact on Fertility

Consult with your doctor on the use of Tegretol La Tablet, if you are trying to conceive. Before taking Tegretol La in women who are attempting to conceive, consult with a doctor as the effects of Tegretol La on the unborn child are harmful.

Seizures

Tegretol La Tablet can make you feel sleepy. Be careful while driving, using machinery, or doing any other activity that needs you to be alert. The consumption of alcohol with Tegretol La Tablet can make you feel more sleepy. Tegretol La Tablet may cause seizures in some people. Discuss with your doctor if you perform activities where a loss of consciousness may cause you or others harm.

Increased Risk

This medicine may increase your sensitivity to sunlight. If this happens, limit your time outdoors and prevent sunburns. Cover your skin or use a sunscreen.

Side-effects in Older Patients

Tegretol La Tablet may increase side-effects in older patients. Elderly patients may see an increased risk of decreased liver function, decreased functioning of kidneys, and decreased heart function.

What precautions should be taken during Pregnancy and Nursing, and administering Tegretol La to Children or the Older Adults?

Pregnant Women

Management or monitoring precaution
Warning: Tegretol La may increase the risk to develop possible harm to the newborn including spine and spinal cord don't form properly (spina bifida).Talk to your doctor immediately if you become pregnant while taking Tegretol La.

Breastfeeding

Management or monitoring precaution
Warning: A patient should take caution when using Tegretol La during breastfeeding as this medicine passes into breast milk and may lead to newborn vomiting (neonatal vomiting), diarrhea, decreased feeding, increased seizures, and slow and ineffective breathing.

Younger Adults Population

No Known Risk
Warning: The safety and effectiveness of Tegretol La have not been confirmed in children.

Older Adults Population

Precaution
Warning: A lower dose is needed for the elderly patient when using Tegretol La.

Tegretol La Side-effects

The following side-effects may commonly occur when using Tegretol La Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following side-effects may commonly occur in older patients on the use of Tegretol La Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:
  • decreased functioning of the kidneys
  • decreased heart function
  • decreased liver function
Rarely, the use of Tegretol La Tablet may cause the following side-effects:
  • a disorder characterized by bumps on the skin (erythema nodosum)
  • abnormal involuntary movements
  • acne
  • aggression
  • an abnormal increase in the number of white blood cells
  • an inflammatory disease that occurs when the immune system attacks its own tissues (lupus erythematosus-like syndrome)
  • blockage of arteries in the lungs due to a blood clot (pulmonary embolism)
  • change in pitch perception
  • circulatory collapse
  • diarrhea
  • double vision (diplopia)
  • excessive production of milk
  • fatigue
  • fluid retention
  • folate deficiency
  • hearing disorder (hyperacusis)
  • hirsutism
  • inability of bone marrow to produce red blood cells (aplasia pure red cell)
  • increase in the number of immature red blood cells (reticulocytosis)
  • increased weight
  • inflammatory liver disease (granulomatous liver disease)
  • involuntary movement of eyes (nystagmus)
  • large production of abnormal red blood cells by bone marrow (megaloblastic anaemia)
  • memory problems
  • muscle weakness due to nerve damage (paresis)
  • muscular weakness
  • painful swelling and sores in the mouth
  • red or purple discolored spots on the skin
  • restlessness
  • ringing in the ears
  • scaling of the skin due to existing skin disorders, drugs, cancer, etc. (dermatitis exfoliative)
  • sedation
  • sexual disturbances/erectile dysfunction
  • shedding of nails (onychomadesis)
  • speech disorder
  • stomach pain (abdominal pain or gastric distress)
  • vision problem (oculomotor disturbances)
The following severe side-effects may also occur when using Tegretol La Tablet:
  • liver disorders (drug-induced serious liver injury)
    Symptoms: jaundice, liver failure or damage, inflammation of the liver and a problem with the transportation of bile (hepatitis of cholestatic) deficiency of an enzyme in the liver (hepatic porphyria)
    Discontinuation of the drug should be done immediately in cases of active liver disease or worsening liver dysfunction.
  • skin disorders (possibly fatal)
    Symptoms: serious and life-threatening skin reactions (Stevens-Johnson Syndrome)
    Inform patients to consult with the doctor or pharmacist immediately if any skin reaction occurs during therapy with Tegretol La. Patients and caregivers should be informed about the risk of possibly fatal, signs and symptoms, and serious skin reactions that may indicate a serious skin reaction.
  • heart and blood disorders
    Symptoms: increased or decreased heartbeat (arrhythmia), decreased heartbeat (bradycardia), damage in heart's major blood vessels (coronary artery disease), high blood pressure, low blood pressure, destruction and removal of red blood cells before their life span (hemolytic anemia), deficiency of red blood cells, white blood cells and platelets (pancytopenia), interruption of transmission of impulses (AV heart block), abnormally low levels of sodium in the blood, a condition in which the body stops producing enough new blood cells (aplastic anemia), an abnormal reduction in white blood cells, an abnormal increase in eosinophils in peripheral blood (peripheral eosinophilia) heart failure (congestive heart failure)
    Reduce the dose when needed. Patients should be advised to report symptoms of low sodium level like nausea, lack of energy, tiredness, seizures, confusion, or more severe seizures to their doctor immediately. Patient having low white blood cell during the course of treatment, should be closely monitored. Discontinue the medicine if any sign of a decrease in the production of leukocytes, erythrocytes, thrombocytes (bone marrow depression) develops. Patients and caregivers should be informed about the risk of possibly fatal lowered white blood cell count or when the body stops producing enough new blood cells and the symptoms that may indicate these reactions.
  • allergic reactions (Possibly fatal)
    Symptoms: drug reaction with eosinophilia and systemic symptoms/multiorgan allergic reactions, severe allergic reaction (anaphylactic reaction) sun allergy (photosensitivity)
    The patient should be evaluated instantly if these signs or symptoms are present. Tegretol La should be discontinued if another cause for the symptoms cannot be discovered.
  • central nervous system disorders
    Symptoms: inflammation of membranes of brain and spinal cord accompanied by contractions of muscles (aseptic meningitis with myoclonus), weakness, numbness and pain due to nerve damage, usually in the hands and feet (peripheral neuropathy), involuntary movements in a sequence (choreoathetosis), hallucinations, depression, agitation, life-threatening reaction or autonomic dysfunction (neuroleptic malignant syndrome), suicidal thoughts (suicidal behavior and ideation), disorder of disturbed activity of nerve cells in the brain (abrupt discontinuation and seizure risk), memory and movement disorders (cognitive and motor problems) confusion
    The patients should be advised to monitor the blood levels and divide the daily dose into smaller dose i.e. 3-4 fractional doses.
  • stomach and intestinal disorders
    Symptoms: loss of appetite (anorexia), a long-term inflammatory bowel disease that causes inflammation in the digestive tract (colitis) inflammatory disease of lymph nodes
  • muscle and coordination disorders
    Symptoms: abnormality in muscular movement (dyskinesia)
  • sensory disorders
    Symptoms: loss of hearing (hypoacusis)
  • kidney disorders
    Symptoms: kidney failure
  • lung disorders
    Symptoms: lung disorder in which air sacs are filled with pus or fluid (pneumonia) shortness of breath
Your doctor has prescribed this medicine because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious cases of side-effects. This page does not contain a complete list of all possible side-effects.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Tegretol La by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:
  • a disorder characterized by bumps on the skin (erythema nodosum)
  • abnormal involuntary movements
  • acne
  • aggression
  • an abnormal increase in the number of white blood cells (leukocytosis)
  • an inflammatory disease that occurs when the immune system attacks its own tissues (lupus erythematosus-like syndrome)
  • blockage of arteries in the lungs due to a blood clot (pulmonary embolism)
  • change in pitch perception
  • circulatory collapse
  • diarrhea
  • double vision (diplopia)
  • excessive production of milk (galactorrhoea)
  • fatigue
  • folate deficiency
  • hearing disorder (hyperacusis)
  • hirsutism
  • inability of bone marrow to produce red blood cells (aplasia pure red cell)
  • increase in the number of immature red blood cells (reticulocytosis)
  • inflammatory liver disease (granulomatous liver disease)
  • involuntary movement of eyes (nystagmus)
  • large production of abnormal red blood cells by bone marrow (megaloblastic anaemia)
  • memory impairment
  • muscle weakness due to nerve damage (paresis)
  • muscular weakness
  • painful swelling and sores in the mouth (stomatitis)
  • red or purple discolored spots on the skin (purpura)
  • restlessness
  • ringing in the ears (tinnitus)
  • scaling of the skin due to pre-existing skin disorders, drugs, cancer, etc. (dermatitis exfoliative)
  • sedation
  • sexual disturbances/erectile dysfunction
  • shedding of nails (onychomadesis)
  • speech disorder (dysarthria)
  • stomach pain (abdominal pain)
  • vision problem (oculomotor disturbances)

Severe Side-effects

Following are the severe side-effects of this medicine:

Side-effects in Older Adults

Following are the side-effects of this medicine in elderly patients:
  • decreased heart function
  • decreased kidney function
  • decreased liver function

Mild Allergic Reactions

Following are the symptoms of mild allergic reactions to this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
  • allergic reaction due to infections (erythema multiforme)
  • drug reaction due to infection (drug reaction with eosinophilia and systemic symptoms)
  • rare and serious skin reaction (Steven-Johnson's syndrome)
  • rash characterized by red areas on the skin (maculopapular eruptions)
  • serious and life-threatening allergic reaction
Contact the healthcare provider right away if you experience any of these symptoms.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Serious allergic reactions

Serious and sometimes fatal skin, nails and hair allergic reactions have been reported with Tegretol La treatment. These serious skin reactions may be accompanied by fever, painful rash, or mucous membrane ulcers. Discontinue Tegretol La if you notice that the patient has a serious skin, nails, hair related allergic reaction. If signs or symptoms suggest serious skin reaction, do not continue therapy with Tegretol La.

Serious blood disorders

When patients with a serious blood disorder (aplastic anemia) and severe lowered white blood cell count were on Tegretol La therapy they were seen with almost all minor blood-related changes which were observed during the monitoring of patients. Pretreatment blood-related testing should be done. If a patient during the therapy exhibits decreased platelet counts or white blood cell, close monitoring of the patient should be done. Tegretol La should be discontinued if any sign of significantly decreased production of blood cells (bone marrow depression) develops.

Severe allergic reaction

Patients who were on anticonvulsant therapy are at an increased risk while using this medicine. These patients may have fever, rash, blood vessels inflammation, disease of the lymph nodes, joint pain, decrease in white blood cells, increase in eosinophils, swelling of both the liver and spleen, abnormal liver function tests and drug-induced liver injury, that may occur in several combinations. Tegretol La should be discontinued if an alternative cause for the symptoms and signs cannot be built. Patients who have earlier experienced a severe allergic reaction to anticonvulsants including primidone, phenytoin, and phenobarbital, should carefully consider the benefits and risks of Tegretol La. If Tegretol La treatment has been started, the signs and symptoms of severe allergic should be monitored carefully.

Suicidal behavior and creative processing (ideation)

Patients taking antiepileptic drugs, including Tegretol La, increase the risk of suicidal thoughts and behavior. Patients, their families, and caregivers should be informed that antiepileptic drugs develop the risk of suicidal thoughts or behaviors. They should be advised about the necessity to be alert for the development or worsening of the symptoms of depression, changes in behavior or mood, thoughts about self-harm or the rise of suicidal thoughts.

Embryo and fetus damage

Pregnant women are at an increased risk when using this medicine. Such patients are at an increased risk to develop possible harm to the newborn including spine and spinal cord don't form properly (spina bifida). Routine prevention of health care during pregnancy is recommended in childbearing women while using Tegretol La.

Sudden withdrawal of Tegretol La

Patients with a seizure disorder who is on treatment with Tegretol La are at an increased risk. Such patients are at an increased risk of developing seizures or seizures that last longer than 5 minutes (status epilepticus) with low oxygen in the blood, a threat to life and other withdrawal symptoms. Do not stop using Tegretol La suddenly.

Low level of sodium in the blood

Patients undergoing treatment with diuretics and elderly patients are at an increased risk of developing a low level of sodium in the blood. Such patients are at an increased risk of developing seizure, focusing problems, memory damage, confusion, headache, weakness, loss of balance (unsteadiness) which may lead to falls. Patients should be advised to discontinue the use of this drug if these reactions occur while taking this drug and appropriate measures should be adopted.

Mental activity and body movement problems

Patients who are on treatment with Tegretol La are at an increased risk of developing problems in judgment, trouble in remembering or learning new things and partial or total loss of function of a body part.

Possibility for loss of antiviral activity

The combined use of Tegretol La with non-nucleoside reverse transcriptase inhibitors including delavirdine is not recommended as it may lead to loss of antiviral activity and possibly cause resistance. The combined use of delavirdine and Tegretol La can decrease the delavirdine levels.

Abnormal heart rhythm

Patients with underlying electrocardiogram abnormalities or risk factors for electrical impulses (conduction) disturbances are at higher risk while using this medicine. Patients who are on treatment with Tegretol La are at an increased risk of developing abnormal heart rhythm (AV heart block) including a second and third-degree block.

Enzyme deficiency occurs in the liver

Patients with a history of an enzyme deficiency that occurs in the liver (hepatic porphyria) are at an increased risk when using this medicine. The patient who is on treatment with Tegretol La is at an increased risk of developing an acute attack of enzyme deficiency occurs in the liver (porphyria). Patients should be advised to avoid the use of the Tegretol La with a history of enzyme deficiency occurs in the liver (hepatic porphyria).

Increased fluid pressure inside the eye

The patient who is on treatment with Tegretol La is at an increased risk of developing fluid pressure inside the eye (intraocular pressure). The patient should be advised to examine intraocular pressure before starting the therapy and regularly during the treatment.

Low levels of thyroid hormones

Tegretol La may lower the blood level of thyroid hormones through enzyme induction. Patients should be advised to raise the dose of thyroid replacement therapy. They should also monitor thyroid function to regulate the dosage of thyroid replacement treatment.

Anticholinergic effects

Tegretol La may increase the actions of the neurotransmitter acetylcholine (anticholinergic action). Patients with increased fluid pressure inside the eye (intraocular pressure) and inability to empty the bladder should be carefully observed during treatment.

Mental disorder (psychiatric effects)

The elderly patient who is on treatment with Tegretol La is at an increased risk of developing the mental disorder (psychosis). Such patients may develop confusion or nervous excitement or worry in the mind.

Interactions with Tegretol La

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
This page does not contain all the possible interactions of Tegretol La Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.
Tegretol La Tablet may interact with Monoamine-oxidase inhibitors (MAOIs) which are used as antidepressants to treat depression, panic disorders, and social phobia. The use of Tegretol La should be avoided in combination with monoamine-oxidase inhibitors (MAOIs). Before giving Tegretol La, MAOIs should be discontinued for at least two weeks, or longer if the clinical situation allows.
There may be an interaction of Tegretol La with Analgesics, which are used to relieve pain and reduce inflammation or swelling. Tegretol La may lower the blood level or even stop the activity of analgesics. Analgesics may also raise Tegretol La blood levels. The dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Tegretol La Tablet interacts with Androgens, which are used to regulate the development and maintenance of male characteristics. Androgens may raise Tegretol La blood levels. When androgen and Tegretol La are used together, the dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Special instructions need to be followed while taking this medicine along with Antibiotics, which are used in the treatment and prevention of bacterial infections. Antibiotics may raise Tegretol La blood levels. Tegretol La may also lower the blood level or even stop the activity of antibiotics. The dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Your doctor's guidelines may need to be followed while taking this medicine along with Antidepressants, which are used to treat depression. Tegretol La may lower the blood level or even stop the activity of antidepressants. Antidepressants may also increase Tegretol La blood levels. When antidepressants and Tegretol La are used together, the dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Tegretol La Tablet may interact with Antiepileptics, which are used in the treatment of disturbed nerve cell activity (epilepsy). The combined use of Tegretol La and levetiracetam has shown to increase Tegretol La-induced damage. Tegretol La may decrease the blood level or even stop the activity of antiepileptic drugs. Antiepileptics may also raise Tegretol La blood levels. The dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
There may be an interaction of Tegretol La with Antifungals, which are used to treat fungal infections such as yeast infection and athlete's foot. Tegretol La may reduce the blood level or even stop the activity of antifungal drugs. Antifungal may increase Tegretol La blood levels. The dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Tegretol La Tablet interacts with Antihistamines, which are used to relieve or prevent the symptoms of allergic response and other types of allergy. Antihistamines may increase Tegretol La blood levels. When antihistamines and Tegretol La are used together, the dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Special instructions need to be followed while taking this medicine along with Antipsychotics, which are used to manage severe mental disorder. Tegretol La may reduce the blood level or even stop the activity of antipsychotics drugs. Antipsychotics may also increase Tegretol La blood levels. The dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Your doctor's guidelines may need to be followed while taking this medicine along with Antituberculosis, which are used for the treatment of easily affected mycobacterial infections. The combined use of Tegretol La and isoniazid has been stated to increase isoniazid-induced liver damage. Antituberculosis may reduce or increase Tegretol La blood levels. When antituberculosis agents and Tegretol La are used together, the dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Tegretol La Tablet may interact with Antivirals, which are used for treating viral infections. Antiviral agents may raise Tegretol La blood levels. Tegretol La may lower the blood level or even stop the activity of antiviral drugs. The dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
There may be an interaction of Tegretol La with Carbonic anhydrase inhibitors (such as acetazolamide), which is used to treat glaucoma. Carbonic anhydrase inhibitors may increase Tegretol La blood levels. The dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Tegretol La Tablet interacts with Drugs used for heart problems (e.g. calcium channel blockers), which are used to treat medical conditions related to the heart or the blood vessels. Blood level may get reduced by Tegretol La usage or it may stop the activity of drugs used for heart problems. The dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Special instructions need to be followed while taking this medicine along with Gastrointestinal drugs (cimetidine and omeprazole), which are used to relieve heartburn, sour stomach, and stomach upset. Gastrointestinal drugs may increase Tegretol La blood levels. The dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Your doctor's guidelines may need to be followed while taking this medicine along with Other interactions such as grapefruit juice which is used to help protect cells from damage or reduce cholesterol and nicotinamide, which is used to prevent and treat pellagra (niacin deficiency). Grapefruit juice and nicotinamide may raise Tegretol La blood levels. The dosage of Tegretol La should be adjusted as increased levels in the blood may result in side-effects such as drowsiness, double vision, dizziness and loss of body movements or the blood levels should be monitored.
Tegretol La Tablet may interact with Antineoplastics, which are used to prevent and block the development of a tumor. Antineoplastics may decrease Tegretol La blood levels. Tegretol La may lower the blood level or stop the activity of antineoplastic agents. The dose of Tegretol La needs to be adjusted when used in combination with antineoplastics.
There may be an interaction of Tegretol La with Bronchodilators (theophylline and aminophylline), which are used for the treatment of breathing difficulties. Bronchodilators may decrease Tegretol La blood levels. Tegretol La may lower the blood level or stop the activity of bronchodilators. Tegretol La dosage needs to be adjusted when bronchodilators are used in combination with Tegretol La.
Tegretol La Tablet interacts with Dermatological drugs (e.g. isotretinoin), which are used to treat skin conditions. Dermatological drugs may reduce Tegretol La blood levels. The dose of Tegretol La needs to be modified when used in combination with dermatological drugs.
Special instructions need to be followed while taking this medicine along with Herbal preparations containing St. John's wort which is used to treat bruises, sprains, and wounds. Herbal preparations containing St. John's wort may decrease Tegretol La blood levels. Tegretol La dosage needs to be adjusted when herbal preparations containing St. John's wort are used in combination with Tegretol La.
Your doctor's guidelines may need to be followed while taking this medicine along with Antiemetics, which are used for the symptomatic management of nausea and vomiting caused by a variety of medical conditions.

Interactions of Tegretol La by Severity

Severe

The following medicines are usually not to be taken together without consulting with your doctor or pharmacist.

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Tegretol La be not used?

Bone marrow depression

Patients who are known to have bone marrow depression should not use Tegretol La. There is a risk of a decrease in the production of leukocytes, erythrocytes, thrombocytes (bone marrow depression). These patients may have the following symptoms if they use this medicine:

Known severe allergic reaction

Patients who are known to have a severe allergic reaction to Tegretol La, such as life-threatening allergic reaction or a serious allergic reaction should not use Tegretol La. Fever, facial swelling, a disease of the lymph nodes, inflammation of the liver (hepatitis), inflamed nephrons (nephritis), blood disorders (hematologic abnormalities), inflammation and damage of the heart muscle (myocarditis), and inflammation in muscles (myositis) were seen in such patients. These patients may have the following symptoms if they use this medicine:
  • fever
  • facial swelling
  • disease of the lymph nodes

Known severe allergy to any of the tricyclic compounds

Patients who are known to have life-threatening allergic reaction or rash to any of the tricyclic compounds such as desipramine, amitriptyline, imipramine, nortriptyline, and protriptyline, should not use Tegretol La.

CYP3A4 substrates

The combined use of delavirdine or other non-nucleoside reverse transcriptase inhibitors that are substrates for CYP3A4 should be avoided with Tegretol La. Tegretol La can mainly decrease the levels of these drugs through the induction of CYP3A4. This can lead to the end of virus response and possible resistance to these medicines.

Monoamine oxidase inhibitors (MAOIs)

Before starting treatment with Tegretol La, discontinuation of MAOIs should be done for a minimum of 14 days. The combined use of both the medicines may cause serotonin syndrome.

Use of nefazodone

The combined use of nefazodone and Tegretol La should not be used. The combined use of nefazodone and Tegretol La may result in inadequate blood levels of nefazodone and its active metabolite to produce a desirable effect.

Heart block or enzyme-deficiency in liver

Tegretol La usage should not be recommended in patients with heart block or a history of enzyme deficiency in the liver (e.g. deficiency of enzyme hydroxymethylbilane synthase (acute intermittent porphyria), skin blistering (variegate porphyria), blistering and weakening of skin (porphyria cutanea tarda).

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Tegretol La is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Tegretol La Tablet .
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