Pree Tablet

Generic Name(s): Prednisolone

Why it's used

Pree Tablet is used to treat certain types of allergies, inflammatory conditions, autoimmune diseases, skin and eye diseases, and cancers. This includes asthma, multiple sclerosis, rheumatoid arthritis, nephrotic syndrome, leukemia, and lymphoma. This medicine works by blocking the response of certain inflammatory cells that cause swelling, redness and pain in the body. Pree is also used to reduce the pain from certain aggressive forms of cancers such as acute leukemia and aggressive lymphomas, and to treat certain endocrinal conditions like decreased hormone production of the adrenal gland and swelling of the thyroid gland.

Corticosteroid

Pree is a prescription medicine that belongs to a class of medicines called Corticosteroid. Corticosteroids are medicines that are used to provide relief for inflammation in the body. They reduce swelling, redness, itching, and certain allergic reactions. They are often used to treat severe skin problems, asthma, and arthritis. Corticosteroids can have side-effects that are very serious as they are very strong medicines.

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How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Pree Tablet. If you have any questions related to this medicine, ask your doctor or pharmacist. Use this medicine as recommended by your doctor.

Pree Tablet is used with food. To prevent irritation in the stomach and intestines. Swallow the whole tablet with or without water. Do not break, chew or split the tablet.

Typical Dosage

The typical dose of Pree is 10-60 mg a day depending on the specific disease and its severity. This medicine is typically used for a period of 3-10 days for asthma. This medicine is not known to be habit-forming.

You should continue to use this medicine as directed by the doctor even if you feel well.

If using the orally-disintegrating form of this medicine, make sure you do not consume any food or fluid 5 minutes before or after taking this medicine. Before taking the medicine out of the package, wash your hands thoroughly. Place the medicine on the tongue. Make sure you do not chew or swallow the medicine. You do not need to drink water after consuming the medicine. In certain cases, the medicine can taste slightly bitter. Also, ensure that you do not break or split the medicine.

When used in the injection form, this medicine is given directly into muscles (intramuscular), joints (intra-articular), or around the body joints (periarticular route).

If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.

Talk to Your Doctor

Talk to your doctor if your condition worsens. You should consult with your doctor before stopping the use of Pree.

Your doctor may recommend a lower initial dose of this medicine to see the impact of this medicine on the body. Please follow your doctor's directions. A lower dose of this medicine may be recommended to reduce the risk of side-effects. Older patients may see an increase in the incidence of side-effects with this medicine. As a result, a lower dose may be recommended for older patients.

When stopping this medicine, you may experience withdrawal symptoms such as an insufficient production of steroid hormones (adrenal insufficiency), and low blood pressure. You may need to gradually decrease the dose of this medicine before stopping.

Use in Children

If you are giving Pree Tablet to a child, be sure to use a product that is meant for children. Before giving this medicine to a child, use the child's weight or age to find the right dose from the product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.

Avoid licorice while using Pree.

Storage

You should store Pree Tablet at room temperature 20-25ºC (68-77ºF), away from moisture, and away from light. Store the medicine away from the reach of children and pets.

Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Pree Tablet for conditions for which it was not prescribed. Do not give Pree Tablet to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

Read more: What are the uses of Pree?

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How to take Pree

The dose and frequency of using Pree will depend on the following factors:

patient's health
the health of the patient's liver
the health of the patient's kidneys
medicines recommended by the doctor
any other medicines being used
herbal supplements being used
response to the medicine

Pree Dosage

Dosage for multiple sclerosis

Adult

Recommended: 200 mg/day for a week, followed by 80 mg/day every other day for one month

Children

Initial: 0.14 mg-2 mg/kg (0.06 mg-0.9 mg/lb of body weight) daily in 3-4 divided doses depending on the severity

Dosage for nephrotic syndrome

Children

Recommended: 60 mg/m2 bsa/day given in three divided doses for 4 weeks and 40 mg/m2 bsa/day single dose should be given on alternate days for 4 weeks

Dosage for asthma

Children

Recommended: 1-2 mg/kg (0.4-0.9 mg/lb of body weight) daily in single or divided doses for 3-10 day bursts

Dosage for allergic and skin disorders

Adult

Initial: 5-15 mg/day

Dosage for collagenosis

Adult

Initial: 20-30 mg/day

Dosage for rheumatoid arthritis

Adult

Initial: 10-15 mg/daily

Dosage for lymphoma

Adult

Initial: 15-60 mg/day

Dosage for blood disorders

Adult

Initial: 15-60 mg/day

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Orally disintegrating tablets

Strength: 10 mg, 15 mg, 30 mg

Tablet

Strength: 5 mg

Suspension for Injection

Strength: 25 mg/ml

Syrup

Strength: 15 mg/5 ml, 10 mg/3.3 ml, 7.5 mg/2.5 ml, 5 mg/1.6 ml

Special Instructions

Eye drops

Shake the bottle well before use and avoid touching the dropper tip against the eye. Close your eyes for 2-3 minutes after inserting an eye drop. If you have poured more than one drop in the same eye, wait for at least 5 minutes before inserting the next drop.

Eye ointment

Thoroughly wash your hands with soap and water. Avoid contact of the tip of the tube against your eye. Generally, a 1/2-inch strip of ointment is used for the effectiveness, unless directed by your doctor. Close your eyes for 1 to 2 minutes to allow the medicine to be fully absorbed.

Injection (intramuscular and intra-articular)

The dose of intra-articular injection depends upon the size of the affected joints. Not more than three joints can be treated in a day. Similarly, the dosage of intramuscular injection depends upon the severe conditions of the disease and response to this medicine.

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued. Avoid taking a repeated dose to make up for a missed dose.

Overdose

What to do if you overdose on Pree?

If you have taken more than the recommended dose of Pree, get medical treatment immediately. In the case of long-term intoxication, vomiting and cleaning out the contents of the stomach (gastric lavage) may help to reduce the toxic effects. Continuous steroid therapy is required to decrease overdose symptoms of Pree.

Symptoms of an overdose of Pree

If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:

abnormal enlargement of the liver
abnormal fat deposits
acne
decreased blood potassium level
decreased glucose tolerance
decreased resistance to infection
dry scaly skin
excessive hair growth (hypertrichosis)
fluid build up inside the body
fractures
headache
high blood pressure
increase in appetite
increased heartbeat
increased sweating
inflammation of a vein due to the blood clot formation (thrombophlebitis)
insufficient production of cortisol hormone (adrenal insufficiency)
irregular periods (accentuated menopausal symptoms)
low bone density (osteoporosis)
menstrual disorders
mental illness
pain from nerve damage (neuropathy)
skin coloration (pigmentation)
skin discoloration (ecchymosis)
skin marks during pregnancy (striae)
stomach ulcer
swelling of the abdomen (abdominal distention)
thinning of scalp hair
weakness
weight gain

If you think you have overdosed on Pree Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Pree

Before you use Pree, tell your doctor of your medical and health history including the following:

a family history of diabetes
abnormal functioning of kidneys
chickenpox
congestive heart failure
epilepsy
glaucoma
high blood pressure
liver failure
measles
patients with blood clotting disorders
patients with hypothyroidism
recurrent episodes of heart attack
severe mood disorders
stomach ulcers
tuberculosis
weakened immune system
weakness in skeletal muscles
women with weakened and brittle bones after menstruation

Before you use Pree Tablet, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.

Before having any surgery when using Pree, tell your doctor and dentist about all the medicinal products you use including prescription and non-prescription medicines, and any herbal supplements.

The use of this medicine may change bone density. Use of this medicine leads to a decrease in bone density. Proper monitoring is required in patients who are receiving long-term corticosteroid treatment.

The use of Pree Tablet may change blood pressure. Use of this medicine may lead to an increase in blood pressure.

The use of this medicine may change intraocular pressure. Use of this medicine may increase the fluid pressure inside the eyes (intraocular pressure).

The use of this medicine may change sodium, and potassium levels in the blood. Use of this medicine may increase sodium and potassium levels in the blood.

Use in Pregnancy

Consult with your doctor on the use of Pree Tablet during pregnancy. Use of Pree during the first trimester of pregnancy may increase the risk of congenital abnormalities of mouth and lips, restricted growth of the fetus in uterus and decrease in birth weight.

Use while Breastfeeding

Consult with your doctor on the use of Pree during breastfeeding. This medicine may pass into breast milk. Hence caution should be exercised when using Pree while breastfeeding, especially when using it for a long period of time.

Impact on Fertility

Consult with your doctor on the use of Pree Tablet, if you are trying to conceive.

Seizures

Pree Tablet can make you feel sleepy. Be careful while driving, using machinery, or doing any other activity that needs you to be alert. The consumption of alcohol with Pree Tablet can make you feel more sleepy. Pree Tablet may cause seizures in some people. Discuss with your doctor if you perform activities where a loss of consciousness may cause you or others harm.

Increased Risk

This medicine can cause stomach bleeding. The use of alcohol/tobacco with Pree may increase the risk. Talk to your doctor if you drink alcohol or smoke regularly. Pree can increase your risk of getting infections/worsen existing infections. Reduce your chances of new infections by washing hands often, avoiding people who are sick, preventing injuries, and by not vaccinating without discussing with your doctor. Corticosteroids may increase the risk of infection if you are suffering from chickenpox, measles and Strongyloides threadworm infestation (intestinal infection). Hence use this medicine with proper care in such patients.

Side-effects in Children

Pree Tablet may cause an increased risk of side-effects in younger patients. Children using this medicine may see an increased risk of delayed growth and development.

Side-effects in Older Patients

Pree Tablet may increase side-effects in older patients. Elderly patients may see an increased risk of high blood glucose level, high blood pressure, low potassium level in the blood, low bone density (osteoporosis), more exposure to infections, and skin thinning.

Long Term Use

Use of this medicine for long-term may increase the risk of damage to the optic nerve (glaucoma), high blood pressure, low bone density, diabetes, low potassium levels in the blood, more exposure to infection and skin thinning particularly in elderly patients. In children, this medicine may lead to delayed growth and development.

What precautions should be taken during Pregnancy and Nursing, and administering Pree to Children or the Older Adults?

Pregnant Women

Consult with doctor

Warning: Use this medicine in pregnancy only when the potential benefit justifies the potential risk to the fetus.

Breastfeeding

Consult with doctor

Warning: During breastfeeding an infant, the lowest effective dose should be prescribed to achieve the desired effect on the fetus.

Younger Adults Population

Management or monitoring precaution

Warning: The lowest effective dose should be prescribed to children to minimize the potential growth effects of Pree on children.

Older Adults Population

Precaution

Warning: A low dose will usually be prescribed to lessen the risk of decreased liver, kidney or heart function.

Pree Side-effects

The following side-effects may commonly occur when using Pree Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:

behavioural and mood changes
fluid buildup inside the body (fluid retention)
glucose intolerance
high blood pressure
increased appetite
problem with the excretion of sodium from the body (sodium retention)
weight gain

The following side-effects may commonly occur in older patients on the use of Pree Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:

high blood glucose level
high blood pressure
low bone density (osteoporosis)
low potassium level in the blood
more exposure to infections
skin thinning

The following side-effects may commonly occur in children when using Pree Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:

delay in growth and development (growth retardation)

Rarely, the use of Pree Tablet may cause the following side-effects:

a small opaque or cloudy area on the backside of the lens (posterior subcapsular cataracts)
abnormal fat deposits
abnormally enlarged liver (hepatomegaly)
acne
bleeding in stomach and intestine
bluish discoloration of skin due to trauma (ecchymose)
decrease in carbohydrate tolerance
disturbed blood flow due to fat deposits in the blood vessels (fat embolism)
dry scalp
emotional instability
expended abdomen due to accumulated gas or fluid (abdominal distention)
extreme happiness (euphoria)
eye bulbing (exophthalmos)
facial puffiness
facial redness
failure of heart circulation (circulatory collapse)
fainting
feeling of discomfort
fluid build up in lungs
fracture of long bones
growth retardation in children
headache
heart enlargement
hiccups
improper wound healing
inadequate pigmentation of the skin (hyper or hypopigmentation)
increased liver enzyme levels in the blood
increased pressure inside the eye
increased pressure within or around the brain
increased sweating
inflammation of the pancreas (pancreatitis)
inflammation of veins due to the blood clot formation (thrombophlebitis)
insomnia
loss of body balance (vertigo)
loss of heart functioning (cardiac arrest)
loss of muscle mass
loss of sensation in foot and ankle (Charcot-like arthropathy)
menstrual abnormalities
mood changes
moon-like face
muscle weakness
nausea
negative nitrogen balance due to protein catabolism
nerve inflammation (neuritis)
pain caused by nerve damage (neuropathy)
palpitation
partial loss of function in lower body parts (paraparesis)
personality changes
red or purplish spots on the skin (petechiae)
sensory disorders
separation of tendon from body tissues (tendon rupture)
skin rashes
skin rashes with itchy and raised bumps
skin thinning
slow heart rate (bradycardia)
spinal compression fractures
stretch marks (striae)
suppressed reactions to skin tests
swelling in body parts
thickening of heart muscles in premature babies (hypertrophic cardiomyopathy)
thin fragile skin
thinning of scalp hair
tingling sensation
unwanted hair growth on female body (hirsutism)
weakened and brittle bones (osteoporosis)
weight gain

The following severe side-effects may also occur when using Pree Tablet:

Neurological diseases such as painful inflammation in the spinal cord (arachnoiditis), inflammation of the brain and spinal cord (meningitis) and nerve damage (neuropathy)
Bleeding in stomach and intestines
Life-threatening allergic reaction (anaphylaxis)
Heart diseases such as heart attack, abnormal heartbeat, clot formation in the blood vessels (thromboembolism) and inflammation of the blood vessels (vasculitis)

Your doctor has prescribed Pree Tablet because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Pree Tablet.

If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Pree by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

behavioral and mood changes
fluid buildup inside the body (fluid retention)
glucose intolerance
high blood pressure
increased appetite
problem with the excretion of sodium from the body (sodium retention)
weight gain

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

a small opaque or cloudy area on the backside of the lens (posterior subcapsular cataracts)
abnormal fat deposits
abnormally enlarged liver (hepatomegaly)
acne
bleeding in stomach and intestine
bluish discoloration of skin due to trauma (ecchymose)
burning sensation in body parts (paresthesia)
decrease in carbohydrate tolerance
disturbed blood flow due to fat deposits in the blood vessels (fat embolism)
dry scalp
emotional instability
expended abdomen due to accumulated gas or fluid (abdominal distention)
extreme happiness (euphoria)
eye bulbing (exophthalmos)
facial puffiness
facial redness
failure of heart circulation (circulatory collapse)
fainting
fluid buildup in lungs
fracture of long bones
growth retardation in children
headache
heart enlargement
hiccups
improper wound healing
inadequate pigmentation of the skin (hyper or hypopigmentation)
increase in serum liver enzyme levels
increased pressure inside the eye
increased pressure within or around the brain
increased sweating
inflammation of the pancreas (pancreatitis)
inflammation of veins due to the blood clot formation (thrombophlebitis)
irregular heartbeat
loss of body balance (vertigo)
loss of heart functioning (cardiac arrest)
loss of muscle mass
loss of sensation in foot and ankle (Charcot-like arthropathy)
malaise
menstrual abnormalities
mood changes
moon-like face
muscle weakness
nausea
negative nitrogen balance due to protein catabolism
nerve inflammation (neuritis)
pain caused by nerve damage (neuropathy)
partial loss of function in lower body parts (paraparesis)
personality changes
red or purplish spots on the skin (petechiae)
sensory disorders
separation of tendon from body tissues (tendon rupture)
skin rashes
skin rashes with itchy and raised bumps
skin thinning
sleep disorder
slow heart rate (bradycardia)
spinal compression fractures
stretch marks (striae)
suppressed reactions to skin tests
swelling in body parts
thickening of heart muscles in premature babies (hypertrophic cardiomyopathy)
thin fragile skin
thinning of scalp hair
unwanted hair growth on female body (hirsutism)
weakened and brittle bones (osteoporosis)
weight gain

Severe Side-effects

Following are the severe side-effects of this medicine:

allergic dermatitis
anaphylaxis
angioedema
arachnoiditis
aseptic necrosis of femoral and humeral heads
cardiac arrest
cardiac arrhythmias
congestive heart failure
convulsions
depression
glaucoma
high blood pressure
hypokalemic alkalosis
manifestations of latent diabetes mellitus
meningitis
myocardial rupture following recent myocardial infarction
pancreatitis
peptic ulcer with possible perforation and hemorrhage
pulmonary edema
secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery or illness)
tachycardia
thromboembolism
ulcerative esophagitis
vasculitis

Side-effects in Older Adults

Following are the side-effects of this medicine in elderly patients:

Side-effects in Children

Following are the side-effects of this medicine in young patients:

delayed growth and development

Mild Allergic Reactions

Following are the symptoms of mild allergic reactions to this medicine:

skin rash

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:

anaphylaxis

Warnings

Kaposi's Sarcoma

Use of Pree may cause cancer in soft tissues (Kaposi's sarcoma).

Neuromuscular Effects

Patients using high doses of this medicine are at high risk of getting diseases related to the muscles (myopathy).

Risk of Osteoporosis

Children, young adults and women who are undergoing or have undergone menopause are at a higher risk. Corticosteroids decrease bone formation because of decreased absorption and increased removal of calcium in the body. This increases the risk of osteoporosis in children, young adults and women who are undergoing or have undergone menopause.

Impact on Eye Health

Long term use of this medicine increases the risk of cataracts, glaucoma, damage to the optic nerves, and infections of the eye. Monitoring of the pressure in the eyes called as intraocular pressure should be performed if this medicine is used for more than 6 weeks. Avoid the use of Pree if you have an eye infection called as ocular herpes simplex.

Live or Live Attenuated Vaccines

Such patients are at increased risk of developing complications because of a lack of immunity in the body. Live vaccines against smallpox (variola infection) should not be given to patients who are receiving immunosuppressive doses of corticosteroids.

Development Problems in Children

Long term use of Pree is linked to negative effects on growth and development in children. Monitor for such effects especially if using this medicine for a long time.

Use in Pregnancy

Using this medicine during pregnancy or if you become pregnant when using this medicine may cause serious health issues in the unborn child. Such effects occur if this medicine is used during the first three months of the pregnancy.

Alterations in Endocrine Functioning

Corticosteroids can cause hormone (hypothalamic-pituitary-adrenal axis) suppression and glucocorticosteroid insufficiency after withdrawal of treatment. This type of insufficiency may continue for months after discontinuation of therapy and can cause mineralocorticoid imbalance. Mineralocorticoid supplementation should be used to overcome the effects of corticosteroid therapy.

Increased Risk of Infections

Use of corticosteroids increases the risk of infections. The body's ability to fight new infections is reduced and existing infections may get masked. These infections include tubercolosis, chickenpox, measles, threadworm infestations, amebiasis and cerebral malaria. You should discuss with your doctor if you have a history, infection or exposure to any of these or other infections.

Patients with Heart/Kidney Dysfunction

Corticosteroids can increase blood pressure, salt or water retention, and also increases potassium and calcium secretion. Potassium supplementation and dietary salt restriction may be necessary for patients with high blood pressure, congestive heart failure, or kidney insufficiency. In such patients, these agents should be used with precaution.

History of Stomach and Intestine Related Disorders

Patients with a history of stomach and intestine related health problems are at a higher risk of getting holes in the stomach or intestines. Corticosteroids also mask signs if such an injury has already occurred.

Behavioral and Mood Changes

Pree can cause behavioral and mood changes including depression, mood swings, insomnia, euphoria, and other personality changes. This medicine can also worsen existing behavioral problems. Consult with your doctor if you see such behavioral changes or have existing behavioral disorders to discuss the impact of this medicine.

Interactions with Pree

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.

This page does not contain all the possible interactions of Pree Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Antidiabetic Agents

Your doctor's guidelines may need to be followed while taking this medicine along with antidiabetic agents, which are used to lower the blood glucose levels. In the case of diabetes, corticosteroids may increase the blood sugar level in the body. Dose adjustment is required in patients receiving anti-diabetic drugs.

CYP3A4 Inducers

Pree Tablet interacts with CYP3A4 inducers (barbiturates, phenytoin, rifampin), which are used to treat certain diseases such as anxiety, depression, seizures, and tuberculosis. This combination may reduce the therapeutic effectiveness of corticosteroids by increasing the rate of metabolism. The dose of Pree should be increased while using both drugs in combination.

Immunosuppressants

There may be an interaction of Pree with cyclosporine, which is used to prevent organ rejection. The combined use of this medicine with Pree may increase the effect of both drugs and may cause seizures. Proper adjustment of dose is required while using both the drugs in combination.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Pree Tablet may interact with non-steroidal anti-inflammatory drugs (aspirin, salicylates), which are used to reduce pain, fever, and inflammation. The combined use of this medicine with corticosteroids may increase the risk of side effects related to stomach and intestine. This medicine should be used with precaution in patients with a rare blood disorder (hypoprothrombinemia).

Anticoagulants

Special instructions need to be followed while taking this medicine along with warfarin and other coumarins, which are used to prevent blood clot formation. The combined use of corticosteroids and warfarin usually prevents the response of warfarin. Coagulation parameters (prothrombin time) should be monitored to maintain the desired anticoagulant effect.

Potassium-Depleting Agents

Your doctor's guidelines may need to be followed while taking this medicine along with potassium-depleting agents (e.g., diuretics, amphotericin B), which are used to treat high blood pressure and fungal infections. The combined use of these medicines may increase the risk of low potassium level in the blood. Also, amphotericin B with corticosteroids may cause heart enlargement and heart failure.

Anticholinesterase Agents

Pree Tablet interacts with anticholinesterase agents, which are used to treat neurodegenerative conditions such as dementia, Parkinson's disease, and Alzheimer's disease. The combined use of anticholinesterase agents and corticosteroids may cause severe weakness in the skeletal muscles. Anticholinesterase agents should be discontinued at least 24 hours before receiving corticosteroid treatment.

Toxoids and Vaccines

Special instructions need to be followed while taking this medicine along with toxoids and live or inactivated vaccines, which are used to treat certain viral infections like mumps, chickenpox, and measles. Long-term use of corticosteroids may decrease the response to toxoids and live or inactivated vaccines. Live vaccines should not be given to patients with the weakened immune system.

CYP3A4 Inhibitors

There may be an interaction of Pree with ketoconazole, macrolide antibiotics, which are used to treat certain conditions like fungal, respiratory, Helicobacter pylori, sexually transmitted, and mycobacterial infections. Ketoconazole lowers the metabolism and may result in an increased risk of side effects of this medicine. The dosage of corticosteroids with such drugs should be reduced to avoid the potential side effects.

Cardiac Glycosides

Pree Tablet may interact with digitalis, which is used to treat heart diseases such as heart failure and palpitation. This medicine may increase the risk of heart palpitation due to low levels of potassium in the blood.

Antitubercular Drugs

Pree Tablet may interact with isoniazid, which is used for the treatment of tuberculosis. Pree may decrease the levels of isoniazid in the blood.

Aromatase Inhibitors

Your doctor's guidelines may need to be followed while taking this medicine along with aminoglutethimide, which is used to treat certain diseases like seizures, breast cancer, prostate cancer, and Cushing syndrome. This combination may reduce the therapeutic effectiveness of corticosteroids by increasing the rate of metabolism. The dose of Pree should be increased while using both drugs in combination.

Oral Contraceptives

Special instructions need to be followed while taking this medicine along with estrogens (oral contraceptives), which are used to reduce menopausal symptoms and prevents the pregnancy. This medicine may increase the effect of corticosteroids by decreasing its metabolism in the liver. Dosage adjustment may be required if estrogens are added to or withdrawn from this combination.

Antivirals

Pree Tablet interacts with an antiviral drug (ritonavir), which is used to treat viral infection. This medicine increases the levels of Pree in the blood.

Cholesterol Lowering Agents

There may be an interaction of Pree with cholestyramine, which is used to lower the high levels of cholesterol in the blood. This medicine may increase the excretion of corticosteroids.

Interactions of Pree by Severity

Severe

The following medicines are usually not to be taken together without consulting with your doctor or pharmacist.

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Pree be not used?

Allergic to Pree

This medicine is not recommended in patients who are allergic to it. These patients may have the following symptoms if they use this medicine:

life-threatening allergic reactions (anaphylactoid reactions)

Viral Infection of an Eye (Ocular Herpes Simplex)

This medicine should not be taken in patients with ocular herpes simplex. Such patients may have an increased risk of corneal abnormalities (corneal perforation).

Live Vaccines Against Smallpox

Live vaccines should not be given to patients who are receiving immunosuppressive doses of corticosteroids. Patients may see an increased risk of brain-related complications at the high dose.

Systemic Fungal Infections

This medicine is not recommended in patients with systemic fungal infections.

Traveling With Medication

Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Pree is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

If there are disposal instructions on the package, please follow the instructions.
If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.

This page provides information for Pree Tablet .

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