Spregal Spray is used for Mite infestations, Body lice, Head lice, Pubic lice, Insecticide, Lice infestations and other conditions. Spregal Spray may also be used for purposes not listed in this medication guide.
Spregal Spray contains Esdepallethrine and Piperonyl Butoxide as active ingredients.
Spregal Spray works by suppressing the insect microsomal enzyme detoxification activity; inhibiting the pyrethroid metabolism;
Detailed information related to Spregal Spray's uses, composition, dosage, side effects and reviews is listed below.


Spregal Spray is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
Learn more: Uses


The following is a list of possible side-effects that may occur from all constituting ingredients of Spregal Spray. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.


Before using Spregal Spray, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
  • avoid contact lenses
  • avoid release to the environment
  • do not eat, drink or smoke when usage of this product
  • do not take by mouth. Consult with your doctor before using this medicine on open wounds, dry, chapped, irritated, or sun-burned skin.
  • wash your hands before and after applying Spregal Spray. Clean and dry the skin area to be treated.
  • do not wash the treated area after immediately applying Spregal Spray. Also avoid the use of other products on the treated area unless directed by your doctor.
  • applying an excessive amount may result in pilling. Use a thinner layer or lesser quantity of medicine to avoid pilling.
  • avoid getting this medication in your eyes or nose or mouth.

Interactions with Spregal Spray

If you use other drugs or over the counter products at the same time, the effects of Spregal Spray may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Spregal Spray may interact with the following drugs and products:
  • Chlorpromazine
  • Diazepam
  • Ethylmorphine
  • Griseofulvin
  • Imipramine
  • Para nitroanisole
  • Phentobarbital
  • Phentolamine
  • Reserpine

When not to use Spregal Spray

Please consult your physician or pharmacist or product package for this information.

Composition and Active Ingredients

Spregal Spray is composed of the following active ingredients (salts)
Please note that this medicine may be available in various strengths for each active ingredient listed above.

Packages and Strengths

Spregal Spray is available in the following packages and strengths
Spregal Spray - Packages: 200

Frequently asked Questions

  • Is Spregal Spray safe to use when pregnant?
    • Piperonyl Butoxide: Please consult with your doctor for case-specific recommendations.
    • Esdepallethrine: Please consult with your doctor for case-specific recommendations.
  • Is Spregal Spray safe while breastfeeding?
    • Piperonyl Butoxide: Please discuss the risks and benefits with your doctor.
    • Esdepallethrine: Please discuss the risks and benefits with your doctor.
  • Can Spregal Spray be used for mite infestations and body lice?
    Yes, mite infestations and body lice are among the most common reported uses for Spregal Spray. Please do not use Spregal Spray for mite infestations and body lice without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Spregal Spray.
  • How long do I need to use Spregal Spray before I see improvement of my conditions?
    TabletWise.com website users have reported 3 days and within 2 hours as the most common time it takes before they saw improvements in their conditions. These times may not be reflective of what you may experience or how you should use this medicine. Please consult with your doctor to check how long do you need to use Spregal Spray. Click here and view survey results to find out what other patients report as time for effectiveness for Spregal Spray.
  • Should I use Spregal Spray empty stomach, before food or after food?
    TabletWise.com website users have most commonly reported using Spregal Spray anytime. However, this may not be reflective of how you should use this medicine. Please follow your doctor's advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Spregal Spray.
  • Is it safe to drive or operate heavy machinery when using this product?
    If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Spregal Spray medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Spregal Spray. Always consult with your doctor for recommendations specific to your body and health conditions.
  • Is this medicine or product addictive or habit forming?
    Most medicines don't come with a potential for addiction or abuse. Usually, the government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
  • Can i stop using this product immediately or do I have to slowly wean off the use?
    Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Other important Information on Spregal Spray

Missing a dose

In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.

Overdosage of Spregal Spray

  • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Spregal Spray, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
  • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
  • Please consult your physician or pharmacist or product package for more information.

Storage of Spregal Spray

  • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
  • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Spregal Spray.

Expired Spregal Spray

  • Taking a single dose of expired Spregal Spray is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drugs. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.

Dosage Information

Please consult your physician or pharmacist or refer to the product package.

Cite this page

APA Style Citation

  • Spregal Spray - Product - tabletwise.net. (n.d.). Retrieved October 23, 2023, from https://www.tabletwise.net/southafrica/spregal-spray

MLA Style Citation

  • "Spregal Spray - Product - tabletwise.net" Tabletwise.com. N.p., n.d. Web. 23 Oct. 2023.

Chicago Style Citation

  • "Spregal Spray - Product - tabletwise.net" Tabletwise. Accessed October 23, 2023. https://www.tabletwise.net/southafrica/spregal-spray.

Last updated date

This page was last updated on 9/27/2020.
This page provides information for Spregal Spray Product in English.
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Pubic Lice
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