When two or more
medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a
Drug Interaction.
Tramadol Hydrochloride Paracetamol Tablet interacts with
carbamazepine, which is used to prevent and control
seizures. When
carbamazepine is used with
Tramadol Hydrochloride
Paracetamol, the pain-reducing effect of Tramadol Hydrochloride Paracetamol is reduced, and the breakdown or elimination of Tramadol Hydrochloride Paracetamol is increased. Tramadol Hydrochloride Paracetamol should not be used in combination with carbamazepine.
There may be an interaction of
Tramadol Hydrochloride Paracetamol with triptans, which are used to treat
migraine. Patients taking triptans in combination with
Tramadol Hydrochloride
Paracetamol may experience increased serotonergic activity in the central nervous system (serotonin
syndrome). Take necessary precautions while using
Tramadol Hydrochloride Paracetamol in combination with triptans.
Your doctor's guidelines may need to be followed while taking this medicine along with
quinidine, which is used to treat or prevent irregular heartbeat. The use of
quinidine with
tramadol may increase the level of
tramadol and lowers the level of the amount of metabolite of Tramadol
Hydrochloride Paracetamol.
Special instructions need to be followed while taking this medicine along with
alcohol, which is used for sleepiness effect.
Alcohol may increase sleepiness effect of
Tramadol Hydrochloride Paracetamol. Thus, the use of alcohol with
Tramadol Hydrochloride
Paracetamol while using machines and driving vehicles may be dangerous. The use of alcohol or alcohol containing products should be avoided while taking Tramadol Hydrochloride Paracetamol.
Your doctor's guidelines may need to be followed while taking this medicine along with serotonergic drugs, used to treat
depression. The use of
Tramadol Hydrochloride Paracetamol with serotonin and
norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (
SSRIs), monoamine oxidase inhibitors (MAOIs), tricyclic
antidepressants, antipsychotics may cause
seizures and serotonin
syndrome in the patients. The use of α2-adrenergic blockers, triptans, St. John’s Wort,
lithium or
linezolid may cause a life-threatening condition (called as, serotonin syndrome) in the patients. Take necessary precautions while using
Tramadol Hydrochloride
Paracetamol in combination with serotonergic drugs.
There may be an interaction of
Tramadol Hydrochloride Paracetamol with
warfarin like compounds, which are used to prevent blood clottimg. The use of
Tramadol Hydrochloride
Paracetamol with warfarin-like compounds may cause an increase in the blood clotting time.
Regularly monitoring of the prothrombin time should be done in the patients using
Tramadol Hydrochloride Paracetamol together with warfarin-like compounds.
Special instructions need to be followed while taking this medicine along with other central nervous system depressants, which are used to treat
anxiety and
insomnia. If the
Tramadol Hydrochloride Paracetamol is used with other central nervous system depressants, such as other anxiolytics, sedative
antidepressants, hypnotics, sedative
antihistamines, centrally-acting antihypertensive drugs, neuroleptics,
thalidomide and
baclofen, the patient may suffer from increased central
depression and the impact on alertness can cause driving and use of machines harmful. Take necessary precautions while using
Tramadol Hydrochloride
Paracetamol in such patients.
There may be an interaction of
Tramadol Hydrochloride Paracetamol with
seizure threshold-lowering medicines. The use of
Tramadol Hydrochloride
Paracetamol with seizure threshold-lowering medicines (for example, tetrahydrocannabinol,
mirtazapine,
bupropion) may cause seizures in the patients. Take necessary precautions while using
Tramadol Hydrochloride Paracetamol in combination with seizure threshold-lowering medicines.
Tramadol Hydrochloride Paracetamol Tablet may interact with other
opioid derivatives (including antitussive drugs and substitutive treatments), benzodiazepines and barbiturates, which are used to treat
anxiety. When the
Tramadol Hydrochloride
Paracetamol is used with other opioid derivative drugs, barbiturates, or benzodiazepines the risk of slow and ineffective breathing increases that can result in the fatality in cases of overdose. Use this medicine with caution in such patients.
This page does not contain all the possible interactions of Tramadol Hydrochloride Paracetamol Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any
medicines without the approval of your doctor.