Your dose and how often you take
Spritam will depend on the following factors:
- age
- weight
- patient's health
- the health of the patient's liver
- response to the medicine
Spritam Dosage
Adult (adults ≥18 years and children of 12 - 17 years with a weight of 50 kg or more than it)
- Initial: 500 mg twice daily, if needed it may be increased or decreased after every two to four weeks. It is given as add-on therapy with Spritam
- Maximum: 1500 mg twice daily
Adult (children and adults from 16 years with newly diagnosed seizures)
- Recommended: 250 mg twice daily, it should be raised to a therapeutic dose of 500 mg initially twice every day after two weeks. It is used as a single drug therapy.
- Maximum: 1500 mg twice daily
Adult (16 years and older patients with unknown epilepsy cause)
- Recommended: 3000 mg and an additional dose of 1000 mg/day may be given every 2 weeks through veins
- Initial: 1000 mg/day (500 mg twice daily)
Children (6 to <16 years)
- Recommended: 60 mg/kg daily dose (27.2 mg/lb) or 30 mg/kg (13.6 mg/lb) twice daily and an additional dose of 20 mg/kg (9.09 mg/lb) may be given every 2 weeks through veins
- Initial: 20 mg/kg (9.09 mg/lb) in 2 divided doses (10 mg/kg or 4.54 mg/lb twice daily) through veins
Adult (16 years or older patients with epilepsy)
- Recommended: 3000 mg/day and an additional dose of 1000 mg/day may be given every 2 weeks through veins
- Initial: 1000 mg/day (500 mg twice daily) through veins
- Maximum: 3000 mg/day
Children (1 month to <6 months)
- Recommended: 42 mg/kg daily dose (21 mg/kg twice daily) and an additional dose of 14 mg/kg may be given every 2 weeks through veins
- Initial: 14 mg/kg (6.36 mg/lb) in 2 divided doses (7 mg/kg or 3.18 mg/lb twice daily) through veins
Children (6 months to <4 years)
- Recommended: 50 mg/kg daily dose (22.7 mg/lb) or 25 mg/kg (11.3 mg/lb) twice daily and an additional dose of 20 mg/kg (9.09 mg/lb) may be given every 2 weeks through veins
- Initial: 20 mg/kg (9.09 mg/lb) in 2 divided doses (10 mg/kg or 4.54 mg/lb twice daily) through veins
Children (4 years to <16 years)
- Recommended: 60 mg/kg daily dose (27.2 mg/lb) or 30 mg/kg (13.6 mg/lb) twice daily and an additional dose of 20 mg/kg (9.09 mg/lb) may be given every 2 weeks through veins
- Initial: 20 mg/kg (9.09 mg/lb ) in 2 divided doses (10 mg/kg or 4.54 mg/lb twice daily) through veins
Adult (adults and children of 12 years or older with epilepsy started in their childhood or in the teen years)
- Recommended: 3000 mg/day and an additional dose of 1000 mg/day may be given every 2 weeks through veins
- Initial: 1000 mg/day or 500 mg twice daily through veins
Dosage calculation for children
To calculate the dosage for children please use the
weight based dose calculator to calculate the appropriate dosage as per the weight of your child.
Forms
Tablet
Strength: 250 mg, 500 mg, 750 mg, and 1000 mg
Injection
Strength: 5 mg/1 ml, 10 mg/1 ml, 15 mg/1 ml, and 100 mg/1 ml
Injection, solution, concentrate
Strength: 100 mg/1 ml and 500 mg/5 ml
Solution
Strength: 100 mg/1 ml, 500 mg/5 ml, 1000 mg/10 ml, and 1500 mg/15 ml
Tablet, extended release
Strength: 500 mg, 750 mg, 1000 mg and 1500 mg
Tablet, film coated
Strength: 250 mg, 500 mg, 750 mg, and 1000 mg
Tablet, film coated, extended release
Strength: 500 mg, 750 mg and 1000 mg
Special Instructions
Creatinine clearance >80 ml/min/1.73 m^2
The dose should be 500 to 1500 mg twice daily in patients having a weight greater than 50 kg with abnormal functioning of kidneys.
Creatinine clearance 50-79 ml/min/1.73 m^2
The dose should be 500 to 1,000 mg twice daily in patients having a weight greater than 50 kg with abnormal functioning of kidneys.
Creatinine clearance 30-49 ml/min/1.73m^2
The dose should be 250 to 750 mg twice daily in patients having weight greater than 50 kg with abnormal functioning of kidneys.
Creatinine clearance <30 ml/min/1.73m^2
The dose should be 250 to 500 mg twice daily in patients having a weight greater than 50 kg with abnormal functioning of kidneys.
Kidney disease
The dose should be 500 to 1000 mg once daily in patients having a weight greater than 50 kg with end-stage kidney disease undergoing a kidney purification process. It is recommended to have a loading dose of 750 mg on the first day of Spritam treatment. During kidney purification therapy, it is advised to have a supplement dose of 250 to 500 mg.
Creatinine clearance >80 ml/min/1.73m^2
The dose should be 7 mg/kg (3.18 mg/lb) to 21 mg/kg (9.54 mg/lb) twice daily in infants (1 to <6 months) with abnormal functioning of kidneys.
Creatinine clearance 50-79 ml/min/1.73m^2
The dose should be 7 mg/kg (3.18 mg/lb) to 14 mg/kg (6.36 mg/lb) twice daily in infants (1 to <6 months) with abnormal functioning of kidneys.
Creatinine clearance 30-49 ml/min/1.73m^2
The dose should be 3.5 mg/kg (1.59 mg/lb) to 10.5 mg/kg (4.77 mg/lb) twice daily in infants (1 to <6 months) with abnormal functioning of kidneys.
Creatinine clearance <30 ml/min/1.73m^2
The dose should be 3.5 mg/kg (1.59 mg/lb) to 7 mg/kg (3.18 mg/lb) twice daily in infants (1 to <6 months) with abnormal functioning of kidneys.
Kidney disease
The dose should be 7 mg/kg (3.18 mg/lb) to 14 mg/kg (6.36 mg/lb) once daily in infants (1 to <6 months) with end-stage kidney disease undergoing kidney purification process. It is recommended to have a loading dose of 10.5 mg/kg (4.77 mg/lb) on the first day of Spritam treatment. During kidney purification therapy, it is recommended to have a supplement dose of 3.5 - 7 mg/kg (1.59 - 3.18 mg/lb).
Missed Dose
It is advised to contact your doctor if you missed one or more doses. A double dose should not be taken to make up for a missed dose.
Overdose
What to do if you overdose on Spritam?
In case of overdose, vomiting should be induced by using the general supportive measure to eliminate the unabsorbed drug from the body. The symptoms of patients should be monitored properly. There is no particular antidote available for the overdose of Spritam.
Symptoms of an overdose of Spritam
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
- aggression
- anxiety
- coma
- reduced awareness
- sleepiness
- slow and ineffective breathing
If you think you have overdosed on Spritam Tablet, call a poison control center immediately. You can look up the poison control center information from the
Poison Center Finder at TabletWise.com.
