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Why it's used

Vibramycin Capsule is used to prevent & treat certain types of infections such as sexually transmitted infections, respiratory tract infections, bacterial infections, eye infections, an infection spread through the bite of infected ticks, lice, mites (rickettsial infections) and serious infections caused by bacterium Bacillus anthracis (anthrax including inhalational anthrax). This medicine may also be used to treat acne, malaria, and parasitic infection of the intestine (intestinal amoebiasis). This medicine works by preventing the growth and reproduction of bacteria by blocking the protein synthesis. Vibramycin is also used to treat a serious gum infection that damages gums and can destroy the jawbone (periodontitis).
Vibramycin Capsule may also be used together with other medicines to treat certain conditions as recommended by the doctor. It is used in combination with Amebicides to prevent & treat Amebicide can be used in combination with Vibramycin to treat parasitic infection of the colon (acute intestinal amebiasis), and severe acne problems. This medicine works by the combined action of preventing the bacterial growth (bacteriostatic) and by killing parasites (amebicides). It is also used with Streptomycin to prevent & treat an infection that spreads from animals to humans, mostly by unpasteurized dairy products (brucellosis) due to Brucella species.
Tetracycline class antibacterial
Vibramycin is a prescription medicine that belongs to a class of medicines called Tetracycline class antibacterial. Tetracycline class antibacterial.

How to use

Follow directions on the product label, information guide, and provided by your doctor before using Vibramycin. Use this medicine as per your doctor's instructions.
Vibramycin is used before food. Vibramycin should be taken at least one hour before meals. If irritation in stomach occurs, Vibramycin can be given with food or milk. Swallow the Vibramycin whole with a sufficient quantity of fluids (at least 100 ml of water). It should be taken in upright sitting or standing position. Vibramycin is used usually before bedtime. In case the patients experience stomach and intestinal side-effects.
The typical adult dose of Vibramycin is 200 mg daily on the first day of treatment (taken as 100 mg every 12 hours) followed by a maintenance dose of 100 mg/day. The typical dose for children is 2 mg/lb (4.4 mg/kg) of body weight divided into two doses on the first day of therapy, followed by 1 mg/lb (2.2 mg/kg) body weight given as a single dose daily or divided into two doses after wards. For more severe infections dose up to 2 mg/lb of body weight can be used. This medicine is commonly used for a period of 10 days for streptococcal bacterial infections, 7 days for uncomplicated urethral, endocervical, or rectal infection, 7 days for inflammation of urethra without gonorrheal infection, 2 weeks for bacterial infection by sexual contact (syphilis), 10 days for inflammation of the epididymis that can extend into the testis (acute epididymo-orchitis), and 60 days for inhalational anthrax (post-exposure). Vibramycin is typically used at the same time every day. There are no known habit-forming tendencies with this medicine.
Vibramycin is to be used for longer periods of time. You should continue to use this medicine as directed by the doctor even if you feel well.
Tell your doctor if your condition persists or worsens or if you develop new symptoms.
To see the impact of Vibramycin Capsule on the body, your doctor may recommend a lower initial dose. Please follow your doctor's instructions carefully. Taking a high dose of this medicine is known to increase the chances of side-effects. A lower dose of Vibramycin Capsule may be recommended to reduce the risk of side-effects.
If you are giving Vibramycin Capsule to a child, be sure to use a product that is meant for use in children. Before giving this medicine, use the child's weight or age to find the right dose from the leaflet or product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
If using the liquid form of this medicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.
If using the delayed-release form of this medicine, do not crush or chew the medicine, unless indicated on the package. Crushing or chewing of the medicine can result in unpleasant taste resulting in patients not following the medicine schedule. Crushing or chewing can also release all of the medicine at once, resulting in a decrease of effectiveness and a possible increase in side-effects.
Your doctor may require that certain tests be performed before using Vibramycin Capsule. The doctor may ask you to have Antibiotic Susceptibility test. Antibiotic susceptibility test is required to help in selecting an appropriate antibacterial drug for treatment. Your doctor may request Automated Immunoassays for Syphilis Antibodies test. When coexistent syphilis is suspected then follow the dark-field examination (laboratory test) and blood serology repeatedly for at least four months.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Vibramycin Capsule for symptoms for which it was not prescribed. Do not give Vibramycin Capsule to others who may have similar symptoms as you. Self-medication can cause harm.
Store Vibramycin Capsule at 25°C (77°F); 15°-30°C (59° - 86°F), and away from moisture. Keep this medicine away from children and pets.

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How to take Vibramycin

The dose and frequency of using Vibramycin will depend on the following factors:
  • age of the patient
  • the weight of the patient
  • patient's health
  • medicines recommended by the doctor
  • any other medicines being used

Vibramycin Dosage

Dosage for long term infections of urinary tract

Adult
  • Recommended: 200 mg should be given on the first day of treatment followed by a maintenance dose of 100 mg once a day or it can be given as 50 mg twice a day
Children (above 8 years and weight less than or equal to 45 kg (100 lb))
  • Recommended: 4.4 mg/kg (2 mg/lb) twice a day on the first day of treatment, followed by 1 mg/lb (2.2 mg/kg) given on subsequent days
Children (above 8 years and weight more than 45 kg (100 lb))
  • Recommended: 200 mg should be given on the first day of treatment followed by a maintenance dose of 100 mg once a day or it can be given as 50 mg twice a day

Dosage for inflammation of the urethra without gonorrheal infection (nongonococcal urethritis)

Adult
  • Recommended: 100 mg by mouth twice a day for 7 days

Dosage for bacterial infection by sexual contact (syphilis)

Adult
  • Recommended: 100 mg by mouth twice a day for two weeks

Dosage for bacterial infection by sexual contact (syphilis)

Adult (patients of more than one-year duration of syphilis)
  • Recommended: 100 mg by mouth twice a day for four weeks

Dosage for prevention of malaria

Adult
  • Recommended: 100 mg daily
Children (above 8 years)
  • Recommended: 2 mg/kg (1 mg/lb) once daily as a starting before 1-2 days of traveling and should be continued up to 4 weeks

Dosage for serious lung infections caused by bacterium Bacillus anthracis (anthrax including inhalational anthrax),

Adult
  • Recommended: 100 mg twice a day given by mouth for up to 60 days
Children (weighing less than 45 kg (100 lb))
  • Recommended: 2.2 mg/kg (1 mg/lb) twice a day by mouth for up to 60 days
Children (weighing equal to or more than 45 kg (100 lb))
  • Recommended: 100 mg twice a day by mouth for 60 days

Dosage for inflammation of the gums (periodontitis)

Adult
  • Recommended: 20 mg twice daily for up to 3 months

Dosage for inflammatory disease of male reproductive system (acute epididymo-orchitis)

Adult
  • Recommended: 100 mg twice a day given by mouth for at least 10 days

Dosage for bacterial infections caused by Streptococcus species (Streptococcal infections)

Adult
  • Recommended: 200 mg should be given on the first day of treatment followed by a maintenance dose of 100 mg once a day or it can be given as 50 mg twice a day
Children (above 8 years and weight less than or equal to 45 kg (100 lb))
  • Recommended: 4.4 mg/kg (2 mg/lb) twice a day on the first day of treatment, followed by 1 mg/lb (2.2 mg/kg) given on subsequent days for ten days
Children (above 8 years and weight more than 45 kg (100 lb))
  • Recommended: 200 mg should be given on the first day of treatment followed by a maintenance dose of 100 mg once a day, or it can be given as 50 mg twice a day for ten days

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 20 mg, 75 mg, 50 mg, 100 mg and 150 mg
Tablet, coated
Strength: 75 mg and 150 mg
Tablet, film coated
Strength: 20 mg, 75 mg, 100 mg and 150 mg
Tablet, delayed release
Strength: 50 mg, 60 mg, 75 mg, 100 mg, 120 mg, 150 mg and 200 mg
Syrup
Strength: 50 mg/5ml
Powder
Strength: 100 mg
Powder for suspension
Strength: 25 mg/5ml

Special Instructions

Oral formulations
Take 200 mg on the first day of treatment (100 mg every 12 hours) followed by a maintenance dose of 100 mg/day
Delayed-release tablets
In delayed-release tablet form of Vibramycin, carefully break up the tablet and sprinkle the contents of the tablet on a spoonful of cold or room temperature applesauce. Do not crush or damage the pellets while breaking up the tablet. Eat the mixture right away and swallow without chewing.

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued. Avoid taking a repeated dose to make up for a missed one.

Overdose

What to do if you overdose on Vibramycin?
Clinicians should have in mind that a significant proportion of overdoses are likely to produce blood levels of Vibramycin within the therapeutic range of antimicrobial therapy, for which there is a large number of data confirming the safety of the drug. In cases of significant overdosage, Vibramycin treatment should be stopped immediately. Treatment according to the symptoms and supportive measures should be undertaken in case of overdose with Vibramycin. The harmful effects of Vibramycin can be reduced by cleaning out the harmful substances of the stomach (gastric lavage). Intestinal absorption of unabsorbed Vibramycin should be reduced by producing non-absorbable chelate complexes by the intake of magnesium or calcium salt-containing antacids.
Symptoms of an overdose of Vibramycin
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
  • inflammation in the pancreas
  • kidney damage
  • long-term liver disease
If you think you have overdosed on Vibramycin Capsule, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Vibramycin

Before you use Vibramycin Capsule, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic to doxycycline hyclate, or other tetracyclines.
Before you use Vibramycin, tell your doctor of your medical history including diarrhea, liver problems, a rare muscle weakness disorder, a yeast infection (thrush), diabetes, acne, or group of rare genetic blood disorders (porphyria). Before having any surgery when using Vibramycin, tell your doctor and dentist about all the medicinal products you use including prescription and non-prescription medicines, and any herbal supplements.
The use of this medicine may change blood urea. Increase in the blood urea levels has been reported with the use of tetracyclines including Vibramycin.
Consult with your doctor on the consumption of alcohol with Vibramycin Capsule.
Vibramycin Capsule is not for use by women and hence pregnant women should not use this medicine. Taking tetracyclines including Vibramycin during the second and third trimester of pregnancy may result in permanent discoloration of the teeth in the child. Women who are breastfeeding should not use this medicine. This medicine passes into breast milk. Vibramycin Capsule may impact fertility in women. If you are trying to conceive, discuss with your doctor on the use of this medicine.
Vibramycin Capsule can make you feel sleepy. Be careful while driving, using machinery, or doing any other activity that needs you to be alert. The consumption of alcohol with Vibramycin Capsule can make you feel more sleepy.
This medicine may increase your sensitivity to sunlight. If this happens, limit your time outdoors and do not tan to prevent sunburns. Cover your skin when you are outdoors or use a sunscreen. In case you get a sunburn, consult with your doctor.
Vibramycin Capsule may cause an increased risk of side-effects in younger patients. Children using this medicine may see an increased risk of permanent discoloration of teeth.
If Vibramycin is used for long-term, it may cause permanent discoloration of the teeth.

What precautions should be taken during Pregnancy and Nursing, and administering Vibramycin to Children or the Older Adults?

Pregnant Women

Contraindication
Warning: Taking tetracyclines including Vibramycin during the second and third trimester of pregnancy may result in permanent discoloration of the teeth in the child.

Breastfeeding

Contraindication
Warning: As severe side-effects may occur to breastfeeding infants, so avoid the use of this medicine in breastfeeding mothers.

Younger Adults Population

Contraindicated or Not Recommended
Warning: Vibramycin should not be used in children up to the age of 8 years due to adverse effects of this medicine on tooth development.

Older Adults Population

Precaution
Warning: Take necessary precautions during dose adjustment for elderly patients suffering from heart, kidney or liver diseases.

Vibramycin Side-effects

The following side-effects may commonly occur when using Vibramycin Capsule. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following side-effects may commonly occur in children when using Vibramycin Capsule. Discuss with your doctor if any of these side-effects last for a long time or are severe:
  • permanent discoloration of teeth (yellow-grey-brown)
Rarely, the use of Vibramycin Capsule may cause the following side-effects:
  • brown-black microscopic discoloration of thyroid glands
  • constipation
  • discoloration of teeth (yellow-grey-brown)
  • dizziness
  • dry mouth
  • flat or raised red bump on the skin (maculopapular rashes)
  • group of genetic blood disorders (porphyria)
  • gum pain
  • hives
  • increase in blood urea nitrogen
  • increased number of eosinophils (eosinophilia)
  • increased pressure inside skull (benign intracranial high blood pressure in adults)
  • inflammation of the tongue (glossitis)
  • muscle pain
  • muscle weakness
  • scaling of the skin (exfoliative dermatitis)
  • stomach pain
  • tooth discoloration
The following severe side-effects may also occur when using Vibramycin Capsule:
  • stomach and intestinal disorders (gastrointestinal disorders)
    Symptoms: severe eating disorder (anorexia), vomiting, diarrhea, difficulty in swallowing (dysphagia), inflammation of the intestine (enterocolitis), inflammation or irritation of the food pipe (esophagitis), ulcers in the food pipe (esophageal ulcerations) inflammation of the colon due to bacteria (pseudomembranous colitis)
  • skin disorders
    Symptoms: redness of the skin (erythematous rashes), flat or raised red bump on the skin (maculopapular rashes), scaling of the skin (exfoliative dermatitis) increased skin sensitivity to the sun (photosensitivity)
  • severe allergic reaction
    Symptoms: wheezing, chest pain, sudden swelling, fever, skin rash, itching of the skin difficulty in breathing
    If such side-effects appear, contact the doctor immediately.
  • Symptoms: destruction of red blood cells (hemolytic anemia), low levels of thrombocytes low level of neutrophils (neutropenia)
  • Symptoms: yellowing of the skin, yellowing of the eyes severe stomach pain
    If this happens, tell the doctor immediately.
  • reaction to endotoxin-like products during antibiotic treatment (Jarisch-Herxheimer reaction)
    Symptoms: blistering of the skin, blistering of mouth or throat, blistering of eyes blistering of genitals
    If such side-effects appear, contact the doctor immediately.
  • severe skin disorder (Steven-Johnsons syndrome)
    Symptoms: fever, chills, headache, skin rash muscle pain
    If this happens, tell the doctor immediately.
Your doctor has prescribed this medicine because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious cases of side-effects. This page does not contain a complete list of all possible side-effects.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Vibramycin by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:

Side-effects in Children

Following are the side-effects of this medicine in young patients:
  • permanent discoloration of teeth (yellow-grey-brown)

Mild Allergic Reactions

Following are the symptoms of mild allergic reactions to this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
  • allergic reaction to the foreign protein (serum-sickness)
  • inflammation and bleeding in the small blood vessels (anaphylactoid purpura)
  • inflammation of the heart membrane (pericarditis)
  • inflammatory autoimmune disease (exacerbation of systemic lupus erythematosus)
  • severe allergic reaction (anaphylaxis)
  • swelling of the lower layer of the skin (angioneurotic swelling)
In case of severe allergic reactions, treatment with Vibramycin should be discontinued, and appropriate safety measures such as giving corticosteroids, sympathomimetics, antihistamines, and artificial respiration should also be provided.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Abnormal functioning of the liver

Vibramycin should be taken cautiously in patients with abnormal functioning of the liver.

Monitoring of laboratory tests while long-term therapy with Vibramycin

In patients for whom long-term therapy is prescribed, laboratory examination of organ systems, including blood, kidney, and liver should be performed at regular time intervals.

Ulceration and irritation in food pipe (oesophageal irritation and ulceration)

Such patients are at an increased risk to develop ulcers and irritation in food pipe when using this medicine. These patients should take adequate fluids so as to avoid the risk of developing ulcers and irritation of food pipe.

Patients with history of fungal infection in the mouth (oral candidosis)

Such patients are at an increased risk of having a fungal infection in the vagina when using this medicine. Take necessary precautions while using this medicine in patients with the history of fungal infection in the mouth.

Syphilis testing

If syphilis along with existing bacterial disease is suspected during the treatment with this medicine, then follow dark-field examinations (laboratory test) before starting the treatment. Another method of laboratory testing (blood serology) should be done repeatedly for at least four months.

Growth and development

Patients who are on treatment with tetracyclines such as Vibramycin have increased chances for the formation of calcium complex with tetracyclines, and therefore the complex does not allow for the growth of bones in the unborn child (premature). These changes are reversible on discontinuation of the drug. In case any tetracycline such as Vibramycin is used during pregnancy or if any patient becomes pregnant while taking such medicine, the patient should be informed about potential harmful effects to the fetus.

Prevention of cell division process (antianabolic action)

The antianabolic action of the tetracyclines may cause an increase in the amount of urea nitrogen in the blood (blood urea nitrogen, BUN). Studies have indicated that this change is not found to occur with the use of Vibramycin in patients with the damaged functioning of kidneys.

Surgical procedures (incision and drainage)

The surgical procedures such as incision and drainage should only be performed when indicated.

Malaria

The use of Vibramycin does not entirely prevent the suppression of asexual blood stages of malaria-causing organisms (Plasmodium parasites).

Drug resistance

The use of Vibramycin in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication does not provide any benefit to the patients and increases the risk of the development of drug-resistant bacteria. Antibiotics should only be prescribed when the bacterial infection has been proven to be present.

Discoloration of teeth

Children up to the age of 8 years are at an increased risk when using this medicine. Such patients have an increased risk of developing permanent discoloration of teeth (yellow-grey-brown) and tooth defect (enamel hypoplasia). These side-effects occur more commonly during long-term use of the medicine. The use of this drug should not be prescribed for children up to 8 years except for a rare and severe bacterial illness (anthrax) until and unless any other effective treatment is not available.

Inflammation of the colon due to the bacteria (pseudomembranous colitis)

Patients who are on treatment with antibacterial agents including Vibramycin are at an increased risk when using this medicine. Such patients may have an increased risk of developing mild diarrhea to fatal colitis due to the disturbed balance of useful bacteria in the intestine which results in overgrowth of bacteria responsible for diarrhea. In case any symptom appears, ongoing treatment with an antibiotic should be discontinued. Supplementation with protein, appropriate fluid and electrolyte management, antibiotic treatment of bacteria responsible for diarrhea (Clostridium difficile), and surgical evaluation if it is clinically indicated should be undertaken.

Increased sensitivity to sun (photosensitivity)

Patients who are on treatment with antibacterial agents including Vibramycin are at an increased risk to develop an enhanced sunburn reaction. Such patients should discontinue the use of the drug in case if they experience an allergic skin reaction (erythema).

Second infection which is superimposed on an earlier infection (superinfection)

Patients who are on treatment with antibacterials including Vibramycin are at an increased risk of developing superinfection by other organisms such as fungi. Such patients should discontinue the use of Vibramycin if superinfection occurs and should start an appropriate therapy.

Brain disorder due to increased pressure inside the skull (benign intracranial high blood pressure)

Patients using tetracyclines such as Vibramycin may develop a condition affecting the brain (bulging fontanels) in infants and benign intracranial high blood pressure in adults. The patients should discontinue the use of the drug after the appearance of these symptoms.

Interactions with Vibramycin

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Vibramycin Capsule interacts with antacids, which are used to treat stomach acidity. Use of antacids with Vibramycin may impact the absorption of Vibramycin from the stomach and intestinal tract.
There may be an interaction of Vibramycin with penicillin, which is helpful against bacterial infections. Use of Vibramycin may interfere with the bactericidal activity of penicillin. It is advisable not to give Vibramycin with beta-lactam antibiotics (penicillins).
Vibramycin Capsule may interact with anticoagulant drugs, which help to prevent blood clots. Tetracyclines such as Vibramycin have been shown to depress the blood clotting time (blood prothrombin activity). Patients who are on therapy of anticoagulants may require downward dose adjustment of anticoagulant dosage. When Vibramycin is taken in combination with anticoagulants, coagulation parameters, including International Normalized Ratio (INR), should be monitored properly. The possibility of an increased risk of bleeding events should be known to the patient.
Your doctor's guidelines may need to be followed while taking this medicine along with barbiturates, which are used to depress central nervous system and anti-epileptics, which are used to prevent seizures. These medicines may enhance the decomposition of Vibramycin in the liver.
Special instructions need to be followed while taking this medicine along with oral contraceptives, which are used for birth control preventive measures. The combined use of Vibramycin with birth control pills (oral contraceptives) may decrease the drug effect of oral contraceptives.
Your doctor's guidelines may need to be followed while taking this medicine along with didanosine, which is used to treat HIV/AIDS. Didanosine may decrease the absorption of Vibramycin due to the increase of pH value in the stomach. Didanosine should, therefore, be used at least 2 hours after intake of Vibramycin.
Special instructions need to be followed while taking this medicine along with cyclosporin, which is used to prevent organ rejection in transplantation procedures. When Vibramycin is used with cyclosporin decrease in the half-life of Vibramycin has been reported.
Vibramycin Capsule interacts with rifampicin, which is used to treat several types of bacterial infections such as tuberculosis. Rifampicin may enhance the decomposition of Vibramycin in the liver.
There may be an interaction of Vibramycin with drug/laboratory test interactions. Due to interference with the fluorescence test, a false increase of urinary catecholamines may occur with the use of Vibramycin.
Vibramycin Capsule may interact with penthrane, which is used as an inhalational anesthetic to provide rapid short-term relief from pain. The combined use of Vibramycin with penthrane (methoxyflurane) may lead to fatal conditions of kidney damage.
Vibramycin Capsule interacts with sulfonylurea oral antidiabetic agents, which are used in the management of high glucose level. Vibramycin has been shown to increase the low blood sugar (hypoglycaemic) effect of sulfonylurea oral antidiabetic agents. If Vibramycin is taken in combination with antidiabetic drugs, blood sugar levels should be monitored properly and if necessary, the doses of both the drugs should be reduced.
There may be an interaction of Vibramycin with quinapril, which is used in the treatment of high blood pressure and congestive heart failure. Quinapril may reduce the absorption of Vibramycin due to the presence of high magnesium content in the quinapril tablets.
Vibramycin Capsule may interact with isotretinoin, which is used in the treatment of severe acne problems. When Vibramycin is taken shortly before, during or after the course of isotretinoin, may lead to increased pressure in the intracranial cavity (pseudotumor cerebri). The combined use of Vibramycin with isotretinoin should be avoided.
This page does not contain all the possible interactions of Vibramycin Capsule. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Interactions of Vibramycin by Severity

Severe

The following medicines are usually not to be taken together without consulting with your doctor or pharmacist.

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Vibramycin be not used?

Infants and children up to age 12

The use of Vibramycin is not recommended in infants and children up to age 12. Children may have permanent decoloration of teeth.

Allergic reaction to Vibramycin, other tetracyclines or any of its components

This medicine should not be used in patients who are allergic to it or any of its components. These patients may have the following symptoms if they use this medicine:
  • hives
  • swelling of the lower layer of skin (angioneurotic swelling)
  • life-threatening allergic reaction (anaphylaxis)
  • inflammation and bleeding in the small blood vessels
  • an allergic reaction to foriegn protein
  • infllammation of the heart membrane (pericarditis)
  • an inflammatory disease in which the immune system attacks its own cells (systemic lupus erythematosus)

An absence of hydrochloric acid in gastric secretions (achlorhydria)

The use of Vibramycin is not recommended in patients with achlorhydria.

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Vibramycin is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Vibramycin Capsule .
Bacterial Infections
Sexually Transmitted Diseases
Eye Infections
Anthrax

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