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Vasopril Tablet

Generic Name(s): Enalapril

Why it's used

Vasopril Tablet is used to treat high blood pressure. This medicine works by blocking the action of angiotensin-converting enzyme (ACE), which is responsible for the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II, that results in increased blood pressure. This medicine helps by reducing the increased blood pressure. Vasopril is also used to treat symptomatic heart failure, and to prevent heart failure in patients with asymptomatic left ventricular dysfunction in the left part of the heart.
Vasopril Tablet may also be used together with other medicines to treat certain conditions as recommended by the doctor. It is used in combination with diuretics to treat high blood pressure and heart failure. It is also used with digitalis to treat heart failure and patients with asymptomatic left ventricular dysfunction in the left part of the heart. It is also used with beta-blockers for the management of heart failure and patients with asymptomatic left ventricular dysfunction in the left part of the heart.
Angiotensin Converting Enzyme Inhibitor
Vasopril is a prescription medicine that belongs to a class of medicines called Angiotensin Converting Enzyme Inhibitor. Angiotensin-converting enzyme (ACE) inhibitors treat a variety of conditions, such as high blood pressure, migraines, and scleroderma. It helps in relaxing the blood vessels.

How to use

Follow directions on the product label, information guide, and provided by your doctor before using Vasopril. Use this medicine as per your doctor's instructions.
Vasopril is used with or without food. The absorption of Vasopril is not interfered by the presence of food. Tap the Vasopril powder bottle for an oral solution on a hard surface for five times. Add about one-half (75 ml) of the diluent to the 150 ml Vasopril powder for Oral Solution. Shake properly for about 30 sec and then reopen. Add the remaining of the diluent to the Vasopril powder for oral solution, and shake well for extra 30 seconds. Calculate 60 days from the date of its preparation. Add "Do Not Use After” or a “Discard After” tag with the calculated date added to the reconstituted Vasopril bottle.
The typical adult dose of Vasopril is 40 mg daily. The typical dose for children is 5 mg once a day. The maximum dose for adults of Vasopril is 40 mg per day. Vasopril is typically used at the same time every day. It takes 1 hour for this medicine to start its action.
This medicine should be used on an as-needed basis. Typically used for long-term in case of high blood pressure. You should continue to use this medicine as directed by the doctor even if you feel well.
Tell your doctor if you develop new symptoms. Talk to your doctor if dizziness, lightheadedness, difficulty in breathing, swelling of the face, swelling of the lips, tongue or throat, swelling of the hands, feet or ankles, rash, peeling skin, sore throat or fever, ringing in the ears, reduction in blood cell count, yellowing of the skin, lower hemoglobin, lowering of blood platelets, temporary loss of consciousness, vomiting, diarrhea, excessive sweating, and dehydration. If you have any kidney disease, For patients with kidney damage, the treatment with Vasopril should be started at a low dose. Also, the dosage interval between taking the next dose of Vasopril should be extended and dosage should be reduced. If you have issues with the health of your liver, The patients who are on treatment with Vasopril and develop yellow discoloration of skin or an increase in liver enzymes should discontinue the use of Vasopril and begin appropriate treatment. Consult with your doctor before stopping the use of Vasopril Tablet.
To see the impact of Vasopril Tablet on the body, your doctor may recommend a lower initial dose. Please follow your doctor's instructions carefully. A lower dose of Vasopril Tablet may be recommended to reduce the risk of side-effects. Older patients may see an increase in the risk of side-effects. Hence, a lower dose may be recommended.
If you are giving Vasopril Tablet to a child, be sure to use a product that is meant for use in children. Before giving this medicine, use the child's weight or age to find the right dose from the leaflet or product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
Limit drinking alcohol with Vasopril.
Your doctor may require that certain tests be performed before using Vasopril Tablet. The doctor may ask you to have Blood Pressure test. Blood pressure should be monitored both before and after the treatment with Vasopril since cases of low blood pressure have been reported. Your doctor may request Kidney Function Panel test. Test for the functioning of kidneys should be performed both before and after the treatment with Vasopril since cases of kidney failure have been reported.
Medicines may be given for uses other than those listed in the medicine guide. Do not use Vasopril Tablet for symptoms for which it was not prescribed. Do not give Vasopril Tablet to others who may have similar symptoms as you. Self-medication can cause harm.
Store Vasopril Tablet 15°C-30°C (59°F-86°F), and away from moisture. Keep this medicine away from children and pets.

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How to take Vasopril

Your dose and how often you take Vasopril will depend on the following factors:
  • age
  • weight
  • patient's health
  • the health of the patient's liver
  • the health of the patient's kidneys
  • response to the medicine

Vasopril Dosage

Dosage for high blood pressure

Adult
  • Recommended: 20mg in a day
  • Initial: 5 mg once per day
  • Maximum: 40 mg once per day or in two divided doses
Children (children more than 1 month of age)
  • Initial: 0.08 mg/kg (0.036 mg/lb) once in a day
  • Maximum: 5 mg in a day

Dosage for symptomatic heart failure

Adult
  • Initial: 2.5 mg twice a day
  • Maximum: 20 mg twice a day

Dosage for heart failure in patients with asymptomatic left ventricular dysfunction in the left part of the heart

Adult
  • Initial: 2.5 mg twice a day
  • Maximum: 10 mg twice a day

Minimum Age

infants more than 1 month

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Forms

Tablet
Strength: 2 mg, 2.5 mg, 4 mg, 5 mg, 8 mg, 10 mg, 16 mg, and 20 mg
Solution
Strength: 1 mg/1mL

Special Instructions

Use with diuretics
Vasopril may use with a low dose of diuretic if further lowering of blood pressure is required and suggested dose in a patient taking diuretics is 2.5 mg daily.
Patients with a low sodium level in the blood
The recommended initial dose is 2.5 mg once daily in the patients with sodium levels in the blood less than 130 mEq/L or blood creatinine greater than 1.6 mg/dL.

Missed Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued. Avoid taking a repeated dose to make up for a missed dose.

Overdose

What to do if you overdose on Vasopril?
The suggested treatment of overdosage is in the veins infusion of normal saline solution. Vasopril may be withdrawn from general circulation by hemodialysis.
Symptoms of an overdose of Vasopril
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
If you think you have overdosed on Vasopril Tablet, call a poison control center immediately. You can look up the poison control center information from the Poison Center Finder at TabletWise.com.

Precautions while using Vasopril

Before you use Vasopril Tablet, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic any of the following substances: previous treatment with an angiotensin-converting enzyme (ACE) inhibitor.
Before you use Vasopril, tell your doctor of your medical and health history including the following: heart disease, kidney disease, hardening of connective tissue (scleroderma), high blood sugar, airway surgery, swelling under the lower layer of the skin, damage in the major blood vessels of the heart, high blood pressure, or low levels of sodium in the blood. Patients who have a history of swelling below lower layer of the skin may be are at an increased risk of some fatal reactions such as swelling of the face, lips, and tongue while receiving treatment with ACE inhibitors. Patients in whom there is an involvement of the tongue, space between vocal folds (glottis) or larynx are likely to experience obstruction of the airways, especially those who have a history of airway surgery. Before having surgery during the use of Vasopril, discuss with your doctor and dentist about the medicinal products you use including prescription/non-prescription/herbal medicines.
The use of this medicine may change red blood cells level. Abnormal deficiency of healthy red blood cells has been reported in patients who are on treatment with ACE inhibitors. The use of Vasopril should be done very cautiously in patients with blood disorders, immunosuppressant therapy, and in patients who are on treatment with other medicines such as allopurinol or procainamide, or if there is existing kidney dysfunction. Patients undergoing treatment with Vasopril should undergo frequent monitoring of blood cells count.
The use of Vasopril Tablet may change white blood cells (agranulocytes and thrombocytes). Abnormal low levels of agranulocytes have been reported in patients who are on treatment with ACE inhibitors. The use of Vasopril should be done very cautiously in patients with blood disorders, immunosuppressant therapy, and in patients who are on treatment with other medicines such as allopurinol or procainamide, or if there is existing kidney dysfunction. Patients undergoing treatment with Vasopril should undergo frequent monitoring of white blood cells count.
The use of this medicine may change potassium levels. The levels of potassium should be monitored carefully in patients on treatment with Vasopril. Drugs that block the renin-angiotensin system can cause an abnormal increase in potassium levels.
Vasopril Tablet can make you feel sleepy. Be careful when using any machinery, driving a vehicle, or doing any other activity that needs you to be fully alert. The consumption of alcohol with Vasopril Tablet can worsen the sleepiness.
The use of Vasopril Tablet is known to be not safe for use in pregnant women. If you are planning to become pregnant or are currently pregnant, you should discuss with your doctor the potential impact of this medicine on the baby before you start to using it. Vasopril causes harm to an unborn baby when it is given to a pregnant woman. Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces the functioning of kidneys of the fetus and increases the risk of fatalities associated with childbirth. The use of Vasopril Tablet is not safe for use in women who are breastfeeding. If you are breastfeeding a baby, discuss with your doctor if you should either discontinue breastfeeding or stop using this medicine while breastfeeding. Vasopril and its breakdown product have been found to be present in human breast milk. Because of the risk of serious side effects in the breastfed child including low blood pressure, abnormally increased levels of potassium in the blood and kidney dysfunction, women should be advised not to breastfeed during treatment with Vasopril. Vasopril Tablet may impact fertility in women. If you are trying to conceive, discuss with your doctor on the use of this medicine. In case you become pregnant during treatment with Vasopril, consult the doctor immediately.
Limit drinking alcohol with Vasopril. Drinking alcohol may cause the enhanced lowering blood pressure effect of ACE inhibitors.
This medicine may increase your sensitivity to sunlight. If this happens, use a sunscreen and cover your skin when you are outdoors. Limit your time in the sun. If you get a sunburn on your skin, consult with your doctor.
Vasopril Tablet may cause increased incidence of side-effects in older patients.

What precautions should be taken during Pregnancy and Nursing, and administering Vasopril to Children or the Older Adults?

Pregnant Women

Contraindication
Warning: Vasopril causes harm to an unborn baby when it is given to a pregnant woman. Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces the functioning of kidneys of the fetus and increases the risk of fatalities associated with childbirth.

Breastfeeding

Contraindication
Warning: Vasopril and its breakdown product have been found to be present in human breast milk. Because of the risk of serious side effects in the breastfed child including low blood pressure, abnormally increased levels of potassium in the blood, and kidney dysfunction, women should be advised not to breastfeed during treatment with Vasopril.

Younger Adults Population

Possibly safe
Warning: Vasopril is not recommended for children of 1 month or less.

Older Adults Population

Precaution
Warning: Elderly patients undergoing treatment with Vasopril are at an increased risk to experience decreased functioning of kidneys. Care should be taken while selecting a dose.

Vasopril Side-effects

The following side-effects may commonly occur when using Vasopril Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
The following side-effects may commonly occur in older patients on the use of Vasopril Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe:
  • kidney dysfunction
Rarely, the use of Vasopril Tablet may cause the following side-effects:
  • abnormal skin sensation (dysesthesia)
  • accumulation of eosinophils in the lungs (eosinophilic pneumonitis)
  • anemia
  • black tarry stools (melena)
  • blockage of arteries in the heart due to a blood clot (pulmonary embolism)
  • change in voice (hoarseness)
  • confusion
  • constipation
  • decrease in blood pressure while standing
  • development of the breasts in males (gynecomastia)
  • dream abnormality
  • dry eyes
  • dry mouth
  • excessive sleepiness
  • excessive sweating (diaphoresis)
  • fever
  • flushing
  • heart attack (cerebrovascular accident)
  • hives
  • inability of a man to achieve an erection during sexual intercourse (impotence)
  • inability of the intestine to contract and move the waste out of the body (ileus)
  • increased number of eosinophils (eosinophilia)
  • indigestion (dyspepsia)
  • inflammation and soreness of the mouth
  • inflammation of blood vessels (vasculitis)
  • inflammation of joints (arthritis)
  • inflammation of muscles (myositis)
  • inflammation of the pancreas (pancreatitis)
  • inflammation of tissues lining chest and stomach (serositis)
  • inflammation of tongue (glossitis)
  • insomnia
  • intense itching
  • kidney dysfunction
  • loss of hair
  • low blood sugar level (hypoglycemia)
  • muscle cramps
  • nervousness
  • numbness in some body parts (Raynaud's phenomenon)
  • pain in joints (arthralgia)
  • pain in muscles
  • pain in the upper part of the stomach, back and sides (Flank pain)
  • presence of excessive proteins in urine
  • rapid or abnormal heartbeat
  • redness and shedding of the skin (exfoliative dermatitis)
  • ringing in the ears (tinnitus)
  • runny nose (rhinorrhea)
  • serious eating disorder (anorexia)
  • sore throat
  • sticky substance within the lungs (pulmonary infiltrates)
  • test for antibodies (positive ANA)
  • test that measures how long red blood cells take to settle down (an increased erythrocyte sedimentation rate)
  • tingling sensation in the skin
  • vertigo
  • vomiting
  • weakness and pain due to nerve damage in hands and feet (peripheral neuropathy)
The following severe side-effects may also occur when using Vasopril Tablet:
  • liver disorders (The use of Vasopril should be discontinued if patients develop such symptoms.)
    Symptoms: liver failure, inflammation of the liver (hepatitis) yellow discoloration of the skin (jaundice)
  • allergic reactions
    Symptoms: serious and life-threatening skin disorder (Stevens-Johnson syndrome), a skin disease characterized by blisters (pemphigus), allergic reactions due to infections (erythema multiforme), sensitivity to the sun (photosensitivity), inflammation of the eye (conjunctivitis), tearing reactivation of the chickenpox virus in the body which causes painful rashes (herpes zoster)
  • heart and blood disorders
    Symptoms: loss of heart function (cardiac arrest), high blood potassium levels (hyperkalemia), reduced heartbeat (bradycardia), irregular and rapid heart rate (atrial fibrillation), abnormally decreased count of neutrophils (rare cases of neutropenia), abnormally decreased count of thrombocytes, decreased production of cells (bone marrow depression), increased number of white blood cells (leukocytosis) heart attack
  • lung disorders
    Symptoms: fluid accumulation in the lungs, lung infection (upper respiratory infection) tightening of muscles of airways of lungs (bronchospasm)
Your doctor has prescribed Vasopril Tablet because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Vasopril Tablet.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Side-effects and Allergic Reactions of Vasopril by Severity and Frequency

Common Side-effects

Following are the common side-effects of this medicine:

Infrequent and Rare Side-effects

Following are the infrequent and rare side-effects of this medicine:

Severe Side-effects

Following are the severe side-effects of this medicine:
  • abnormally decreased count of neutrophils (rare cases of neutropenia)
  • abnormally decreased count of thrombocytes (thrombocytopenia)
  • allergic reactions due to infections (erythema multiforme)
  • bronchospasm or asthma
  • decreased production of cells (bone marrow depression)
  • fluid accumulation in the lungs
  • herpes zoster
  • high blood potassium levels (hyperkalemia)
  • increased number of white blood cells (leukocytosis)
  • inflammation of the eye (conjunctivitis)
  • irregular and rapid heart rate (atrial fibrillation)
  • liver failure (hepatic failure)
  • loss of heart function (cardiac arrest)
  • lung infection (upper respiratory infection)
  • reduced heartbeat (bradycardia)
  • sensitivity to the sun (photosensitivity)
  • serious and life-threatening skin disorder (Stevens-Johnson syndrome)
  • skin disease characterized by blisters (pemphigus)
  • tearing

Side-effects in Older Adults

Following are the side-effects of this medicine in elderly patients:
  • kidney dysfunction

Mild Allergic Reactions

Following are the symptoms of mild allergic reactions to this medicine:

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority. You can look up the drug authority contact information from the Drug Authority Finder at TabletWise.com.

Warnings

Patients with low blood sugar

Patients who are on treatment with blood sugar lowering agents and Vasopril such as Vasopril are at an increased risk to develop low blood sugar during the first month of the treatment with this combination. Such patients should be informed to closely monitor for reduced levels of sugar in the blood.

Decreased white blood cells (neutrophils, thrombocytes, or agranulocytes)

Patients who are undergoing treatment with Vasopril, who have blood disorders, undergoing immunosuppressant therapy, patients who are on treatment with other drugs such as allopurinol or procainamide, in addition to existing kidney failure are at an increased risk when using this medicine. These patients have experienced a decrease in the number of white blood cells in the blood. Vasopril should be used under careful supervision in such patients and frequent monitoring of white blood cells is advised to patients. They should also be informed to report any sign of infection.

Abnormal thickening of heart muscles

Patients with problems in blood flow from the heart (left ventricular valvular and outflow tract obstruction) are at an increased risk when using this medicine. Such patients who have left ventricular valvular and outflow tract obstruction should take Vasopril with caution. It should be avoided in patients with cardiogenic shock in which heart cannot pump enough blood to meet the needs of the body and who have significant obstruction of blood.

Anaphylactoid reactions (during desensitization and dialysis)

Patients experiencing low-density lipoprotein apheresis with dextran sulfate absorption, desensitizing therapy with Hymenoptera venom while receiving Vasopril, and patients dialyzed with high-flux membranes and treated in combination with Vasopril are at an increased risk for life-threatening allergic reaction. Dialysis must be stopped instantly, and aggressive therapy for allergic reactions must be started in such patients. A different kind of dialysis membrane or a distinct class of antihypertensive agent should be considered in such patients.

Swelling in the lower layer of the skin

Patients with a history of swelling of the lower layer of the skin unrelated to ACE inhibitor therapy, combined use of Vasopril and mTOR inhibitor (e.g., temsirolimus, everolimus, and sirolimus) therapy may be at an increased risk. Swelling of the face, lips, extremities, tongue, glottis or larynx, including fatal reactions, have occurred in patients treated with Vasopril. These patients are likely to experience airway obstruction, especially those with a history of airway surgery. Intestinal swelling has been seen in patients treated with Vasopril. These patients were shown to have stomach pain with or without vomiting or nausea; in some cases, there was no history of facial swelling and level of C-1 esterase were normal. Vasopril should be immediately discontinued and proper therapy or monitoring should be given until full and continued purpose of signs and symptoms of swelling of the lower layer of the skin has appeared. Swelling of the lower layer of the skin should be diagnosed by procedures including ultrasound or abdominal CT scan, or at surgery, and symptoms solved after stopping Vasopril.

Increased potassium level

Patients with high blood sugar (diabetes mellitus), poor function of the kidneys, and the combined use of potassium-sparing diuretics, potassium-containing salt substitutes or potassium supplements are at an increased risk of a rise of high potassium level. Drugs that block the renin-angiotensin system can cause high potassium level. Potassium levels in the blood should be monitored in patients receiving Vasopril.

Abnormal functioning of kidneys

Patients with narrowing of arteries carrying blood to one or both of the kidneys (kidney artery stenosis), severe congestive heart failure, long-term kidney disease, and post-heart attack or volume depletion may be at an increased risk of acquiring acute kidney failure when using this medicine. Changes in the functioning of kidneys including acute kidney failure can be induced by Vasopril. Also, such patients are at an increased risk to experience a change in blood levels of creatinine. Monitoring of the functioning of kidneys is required in patients treated with Vasopril. Discontinuation of the therapy is recommended in patients with a decrease in the functioning of the kidney.

Liver failure

ACE inhibitors including Vasopril have been related to a syndrome that starts with reduced bile flow from the liver (cholestatic jaundice) and progresses to a severe abnormality of liver function (hepatic necrosis) and sometimes fatal. Patients taking ACE inhibitors who develop yellowing of the eyes and skin (jaundice) or raised liver enzymes should discontinue ACE inhibitor and seek proper medical follow-up.

Low blood pressure

Patients with severe narrowing of the valve of aorta (aortic stenosis) or thickening of heart muscle (hypertrophic cardiomyopathy), heart failure with systolic blood pressure below 100 mmHg, ischemic heart disease, brain disease, low sodium level, high dose diuretic therapy, kidney dialysis, and salt depletion or severe volume of any cause are at an increased risk when using this medicine. Vasopril can cause symptomatic low blood pressure, sometimes complicated by decreased production of urine, abnormally high levels of nitrogen-containing compounds, acute kidney failure or fatality. In patients undergoing extreme surgery or while using anesthesia with agents that produce low blood pressure, Vasopril may block angiotensin II production secondary to renin release. Also, such patients are at an increased risk to experience a change in blood levels of creatinine. In patients with low blood pressure, Vasopril should be started under close medical supervision, and such patients should be followed nearly for the first two weeks of therapy and whenever Vasopril dose or diuretic dose is raised. In patients undergoing surgery or anesthesia, if low blood pressure occurs and is considered to be through angiotensin II production mechanism, it can be improved by volume expansion.

Fetal damage

Pregnant women and newborns are at an increased risk when using this medicine. Use of Vasopril during pregnancy (second and third trimesters) reduces fetal functioning of kidneys, increases fetal and newborn diseased state and fatality rate. It can result in a deficiency of amniotic fluid which can be related to fetal lung incomplete development (hypoplasia) and skeletal abnormalities. Possible neonatal side effects include an underdeveloped skull, non-passage of urine, low blood pressure, kidney failure, and fatality. Discontinue Vasopril as soon as pregnancy is suspected.

Cough

The patients who are on treatment with Vasopril are at an increased risk to develop cough which disappears after the drug is discontinued.

Patients undergoing surgery or temporary loss of consciousness (anesthesia)

Patients undergoing major surgery or anesthesia along with drugs that result in reduced blood pressure, Vasopril blocks the formation of angiotensin II, a substance which is responsible for the constriction of vessels. If a reduction in blood pressure occurs due to this mechanism, volume expansion can be used as a correcting measure.

Patients taking lithium

Treatment with lithium and Vasopril is generally not recommended.

Blockage of the renin-angiotensin-aldosterone system (RASS)

The patients who are on treatment with Vasopril, angiotensin II receptor blockers and aliskiren are at an increased risk. Such patients may develop low blood pressure, increased levels of potassium in the blood, and decreased functioning of kidneys. Dual blockage of RASS due to the use of Vasopril, angiotensin II receptor blockers and aliskiren in combination is not recommended.

Patients with lactose intolerance

Patients with family history problems of inability to digest galactose (galactose intolerance), deficiency of lactase enzyme (Lapp lactase deficiency) or glucose-galactose intolerance are at an increased risk because Vasopril contains lactose which will not be absorbed if taken by such patients. The use of Vasopril in such patients is not recommended.

Interactions with Vasopril

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called as a Drug Interaction.
Your doctor's guidelines may need to be followed while taking this medicine along with Gold (sodium-aurothiomalate) which is used for its anti-inflammatory action in the treatment of rheumatoid arthritis. Symptoms such as nausea, facial flushing, vomiting, and low blood pressure have been notified rarely in patients on treatment with sodium aurothiomalate (injectable gold) and Vasopril therapy together.
Vasopril Tablet interacts with Agents increasing blood potassium levels such as spironolactone, triamterene, or amiloride, which are used to treat low potassium levels and heart failure. Vasopril reduces potassium loss caused by thiazide-type diuretics. Potassium supplements, or potassium-containing salt substitutes, potassium-sparing diuretics may lead to a notable increase in blood potassium level.
There may be an interaction of Vasopril with Renin-angiotensin inhibitors, which are used to reduce high blood pressure. Increased risks of low blood pressure, high potassium level, and changes in the functioning of kidneys (including acute kidney failure) are associated with dual blockade of the renin-angiotensin system with Vasopril. Combined usage of RAS inhibitors should be avoided. Close monitoring of blood pressure, the functioning of kidneys, and electrolytes in patients on Vasopril and other agents that affect the renin-angiotensin system. The use of aliskiren with Vasopril in patients with kidney abnormality and diabetes should be avoided.
Vasopril Tablet may interact with Non-Steroidal Anti-Inflammatory Agents (NSAIDs), which are used as pain relievers and in a condition such as arthritis. It may result in deterioration of the functioning of kidneys, including potential acute kidney failure which usually is reversible. NSAIDs may also reduce the antihypertensive effect of Vasopril. Monitor functioning of kidneys regularly in patients taking Vasopril and NSAID therapy.
Special instructions need to be followed while taking this medicine along with Lithium which is used to treat mental illnesses, eating disorders, and blood disorders. Lithium poisoning has been notified in patients taking Vasopril and lithium together which was usually reversible. Blood lithium levels should be monitored frequently if Vasopril is taken in combination with lithium.
Your doctor's guidelines may need to be followed while taking this medicine along with Other antihypertensives, which are used to treat high blood pressure. The use of antihypertensive agents and Vasopril together may increase the blood pressure lowering effects of Vasopril. The use of nitroglycerine and other nitrates or vasodilators with Vasopril may further decrease the blood pressure.
Vasopril Tablet interacts with Sympathomimetics, which are used to treat low blood pressure. Sympathomimetics may decrease the blood pressure lowering effects of Vasopril.
Special instructions need to be followed while taking this medicine along with Co-trimoxazole, which is used to treat certain bacterial infections. Patients taking Vasopril and trimethoprim/sulfamethoxazole (co-trimoxazole) together may be at an increased risk for high potassium level.
There may be an interaction of Vasopril with Alcohol, which is used as an antiseptic, disinfectant, and an antidote. Alcohol enhances the blood pressure lowering effect of Vasopril.
Vasopril Tablet may interact with mTOR inhibitors, which are used in the treatment of kidney cancer. Patients taking Vasopril and mTOR inhibitor (e.g., sirolimus, temsirolimus, everolimus) treatment may be at an increased risk for swelling of the lower layer of the skin.
Vasopril Tablet may interact with Tricyclic antidepressants, which are used to treat depression, anxiety, and certain kinds of pain. The combined use of tricyclic antidepressants with Vasopril may result in further lowering of blood pressure.
There may be an interaction of Vasopril with Diuretics (thiazide or loop diuretics), which are used to treat high blood pressure. History of high dose diuretics use may result in volume depletion and a risk of low blood pressure when starting therapy with Vasopril. The blood pressure lowering effect can be decreased by the discontinuation of the diuretic, by salt intake, or increasing volume or by starting therapy with a low dose of Vasopril.
This page does not contain all the possible interactions of Vasopril Tablet. Share a list of all medicines that you use with your doctor and pharmacist. Do not start, stop, or change the dose of any medicines without the approval of your doctor.

Interactions of Vasopril by Severity

Serious

The following medicines may interact when taken together and can cause harmful effects in the body. Please consult with your doctor or pharmacist before taking these medicines together.

Moderate

The following medicines may interact when taken together and can increase your risk of harmful effects. Please consult with your doctor or pharmacist before taking these medicines together.

When should Vasopril be not used?

Swelling of the lower layer of the skin

Vasopril should not be used in patients with a history or a family history of swelling of the lower layer of the skin. It is also not to be used in patients with an unknown cause of swelling of the lower layer of the skin. These patients may have the following symptoms if they use this medicine:
  • swelling of the face, extremities, lips, tongue and glottis
  • swelling of larynx
  • blockage in any part of the airway (airway obstruction)

Use of Aliskiren

Aliskiren should not be used with Vasopril in patients with diabetes or kidney abnormality. These patients may have the following symptoms if they use this medicine:
  • decreased blood pressure
  • increased level of potassium
  • changes in the functioning of kidneys
  • acute kidney failure

Use in pregnancy

Vasopril should not be used in second and third trimesters of pregnancy. Vasopril causes harm to an unborn baby when it is given to a pregnant woman. Using drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces the functioning of kidneys of the fetus and increases the risk of fatalities associated with childbirth.

History of a severe allergic reaction related to previous therapy with Vasopril

Vasopril should not be used in patients with a history of severe allergic reaction. There is a risk of sudden and possibly life-threatening allergic reactions. These patients may have the following symptoms if they use this medicine:
  • redness and peeling of the skin over the body (exfoliative dermatitis)
  • severe skin reaction
  • watery blisters form on the skin (pemphigus)
  • severe painful rash (herpes zoster)
  • infectious skin reaction (erythema multiforme)
  • hives
  • severe itching
  • hair loss
  • flushing
  • excessive abnormal swelling (diaphoresis)
  • sun allergy

Traveling With Medication

  • Ensure that you carry enough doses of each of your prescription medicines to last the entire trip. The best place to store your medicines is in the carry on baggage. However, while flying, if carrying liquid medicines, make sure you do not go over the limits imposed for carry-on liquids.
  • While traveling overseas, make sure that you can carry each of your prescription medicines legally to your destination country. One way to ensure this is by checking with your destination country's embassy or website.
  • Make sure that you carry each of your medicines in their original packaging, which should typically include your name and address, and the details of the prescribing doctor.
  • If your travel involves crossing time zones, and you are required to take your medicine as per a fixed schedule, make sure that you adjust for the change in time.

Expired Medication

Taking a single dose of expired Vasopril is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Safe Disposal of Medication

  • If there are disposal instructions on the package, please follow the instructions.
  • If there are medicine take-back programs in your country, you should contact the respective authority to arrange for the disposal of the medicine. For example, in the USA, the Drug Enforcement Administration regularly hosts National Prescription Drug Take-Back events.
  • If there are no take-back programs, mix the medicine with dirt and place them in a sealed plastic bag. Throw the plastic bag in your household trash. Separately, remove all personal information including the prescription label from the medicine packaging and then dispose off the container.
  • If specifically indicated on the medicine package that it needs to be flushed down the toilet when no longer needed, perform the required step.
This page provides information for Vasopril Tablet .
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